Tag: M.W:200-300

Related Products of 175204-82-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 175204-82-7, name is Methyl 4-(trifluoromethyl)nicotinate. A new synthetic method of this compound is introduced below.

Step 2; In a 100 mL flask was placed 1.84 g (9.7 mmol, 1 eq) of methyl 4- trifluoromethylnicotinate in 25 mL of 1 M HCI in CHsCOOH. To this was then added 1.3 g of NCS (9.7 mmol, 1 eq) and the reaction allowed to. stir overnight. (18h). The mixture was then transferred to a 500 mL Erlenmeyer flask and to this was added 300 mL of 2 M HCI in Et20 with stirring. This resutted in a. white precipitate which was then filtered to provide 1.2 g (49%) of the desired 2-chloro-1-[4-(trifluoromethyl)-3- pyridinyl] ethanone hydrochloride as a white solid. 1H-NMR (DMSO-d6) No. 9. 21 (s, 1H), 9.02 (d, 1H), 7.94 (d, 1H), 5.19 (s, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,175204-82-7, its application will become more common.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2003/72561; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1026201-45-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1026201-45-5, name is 8-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid, molecular formula is C8H5BrN2O2, molecular weight is 241.04, as common compound, the synthetic route is as follows.

SOCl2 (15 ml, 206 mmol) was added slowly to intermediate 39 (1.6 g, 6.6 mmol) while cooling on ice. The resulting solution was heated to reflux temperature for 4 h, and was then cooled to r.t. and concentrated in vacuo. The residue was triturated with DIPE and finally the product was dried. Yield: 1.7 g of intermediate 40 (99 %).

Statistics shows that 1026201-45-5 is playing an increasingly important role. we look forward to future research findings about 8-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid.

Reference:
Patent; ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC; GIJSEN, Henricus, Jacobus, Maria; MACDONALD, Gregor, James; BISCHOFF, Francois, Paul; TRESADERN, Gary, John; TRABANCO-SUAREZ, Andres, Avelino; VAN BRANDT, Sven, Franciscus, Anna; BERTHELOT, Didier, Jean-Claude; WO2010/70008; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1206775-52-1, name is 5-Bromo-6-methoxypicolinaldehyde, the common compound, a new synthetic route is introduced below. Recommanded Product: 5-Bromo-6-methoxypicolinaldehyde

(1) (5R) -5 – [(1,3- benzothiazol-2-ylsulfonyl) methyl] pyrrolidin-2-one (2.80 g), in tetrahydrofuran (170 mL) solution of lithium chloride (824 mg), argon gas atmosphere, at -78 , toluene solution (0.5M, 39mL) of potassium hexamethyldisilazide, and the mixture was stirred at the same temperature for 1 hour. Tetrahydrofuran (10 mL) solution was added to thereto 5-bromo-6-methoxy-pyridine-2-carbaldehyde (1.75g), and stirred at the same temperature for 30 minutes. The reaction mixture was poured into a saturated aqueous solution of ammonium chloride, and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, after filtration, concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (chloroform: ethyl acetate = 50: 50) to give, (5R) -5 – [(Z) -2- (5- bromo-6-methoxy-pyridin-2-yl) ethenyl] pyrrolidin-2-one (900 mg) as a pale yellow oily substance.

The synthetic route of 1206775-52-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAISHO PHARMACEUTICAL COMPANY LIMITED; NISSAN CHEMICAL INDUSTRIES LIMITED; KURODA, SHOICHI; USHIKI, YASUNOBU; KAWAGUCHI, TAKANORI; FUSEGI, KEIKO; BOHNO, MASAHIRO; IMAI, YUDAI; UNEUCHI, FUMITO; IWAKIRI, KANAKO; TANAKA, HIROAKI; BOHNO, AYAKO; CHONAN, TOMOMICHI; ITOH, SHIN; OTA, HIROFUMI; ISHIYAMA, SEISHI; OKADA, TAKUYA; SASAKO, SHIGETADA; MONMA, SOUICHI; NIWA, MARIE; OKADA, TAKUMI; (289 pag.)JP2015/231988; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 866775-18-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 866775-18-0, name is Methyl 3-amino-6-bromo-5-(trifluoromethyl)picolinate. This compound has unique chemical properties. The synthetic route is as follows.

3-Amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester (1.40 g, 4.68 mmol) was suspended in MeOH (15 ml); Sodium hydroxide (2.0 M aqueous solution) (14.04 ml, 28.1 mmol) was added and the suspension was stirred at RT overnight. The reaction mixture was concentrated under reduced pressure and the resulting residue was dissolved in water (100 ml) and then acidifed by the addition of 5.0M HCI(aq). The product was extracted into ethyl acetate (2 x 75 ml) and the combined organic extracts were washed with water (50 ml), brine (25 ml), dried (MgS04) and concentrated under reduced pressure to afford the title product as a yellow solid. H-NMR: 9400MHz, DMSO-d6) ? 13.24 (1 H, br s, C02H), 7.74 (1 H, s, ArH), 7.17 92H, br s ArNH2). m/z 285.1 , 287.1 [M+H]+

According to the analysis of related databases, 866775-18-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; LEGRAND, Darren, Mark; WO2013/38381; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 38923-08-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 38923-08-9, name is Ethyl 6-nitroimidazo[1,2-a]pyridine-2-carboxylate. A new synthetic method of this compound is introduced below.

A solution of 250mg (1.01 mmol) of ethyl 6-ni-troimidazo[ 1 ,2-a]pyridine-2-carboxylate in 20 ml of ethanolwas hydrogenated in the presence of 30 mg of palladium(10% on activated carbon) at RT and standard pressure for5 h. The reaction mixture was then filtered through Celiteand the residue was washed with ethanol. The combinedfiltrates were concentrated under reduced pressure and dried.Yield: 215 mg (quant.)10502] LC/MS [Method 5]: R=1.40 mm; MS (ESIpos):mlz=206 (M+H),10503] ?H-NMR (400 MHz, DMSO-d5): oe [ppm]=8.33 (s,1H), 7.66 (s, 1H), 7.37 (d, 1H), 6.94 (dd, 1H), 5.11 (s, 2H),4.26 (q, 2H), 1.29 (t, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,38923-08-9, Ethyl 6-nitroimidazo[1,2-a]pyridine-2-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; Bayer Pharma Aktiengesellschaft; ROeHRIG, Susanne; HILLISCH, Alexander; STRASSBURGER, Julia; HEITMEIER, Stefan; SCHMIDT, Martina Victoria; SCHLEMMER, Karl-Heinz; TERSTEEGEN, Adrian; BUCHMUeLLER, Anja; GERDES, Christoph; SCHAeFER, Martina; TELLER, Henrik; JIMENEZ NUNEZ, Eloisa; SCHIROK, Hartmut; KLAR, Juergen; (66 pag.)US2016/272637; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 55304-80-8, Adding some certain compound to certain chemical reactions, such as: 55304-80-8, name is 2,6-Dibromo-3-nitropyridine,molecular formula is C5H2Br2N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55304-80-8.

N, N-Dimethyl-N’- (6-bromo-3-nitropyridin-2-yl) sulfonic acid Stir a mixture of 2,6-dibromo-3-nitropyridine (11. 3g, 39.25 mmol) and N, N- dimethylsulfamide (0.006 g, 47.10 mmol) in DMF (40 mL). Add lithium hydride (0.81 g, 102.05 mmol) and stir at RT overnight. Add 100 mL of water and 3 N HC1 until pH = 7. Filter the yellow solid to provide the title compound (93%). 1H NMR (DMSO-d6) 8 10.25 (br s, 1H), 8.41 (d, J= 8.59 Hz, 1H), 7.50 (d, J= 8.59 Hz, 1H), 2.95 (2,6H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 55304-80-8, 2,6-Dibromo-3-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/75478; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 59782-86-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59782-86-4, name is 2-Chloro-5-iodonicotinic acid, molecular formula is C6H3ClINO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 4-fluorophenol (224 mg, 2.0 mmol) in DMF (5.0 mL) was added sodium hydride (48 mg, 2.0 mmol) at room temperature. After stirring for 10 min, methyl 2-chloro-5-iodonicotinate (J. Org. Chem. 1989, 54, 3618-3624, 594 mg, 2.0 mmol) was added to the reaction mixture. The reaction mixture was stirred under reflux for 16 h. Then the reaction mixture was poured into water (50 mL) and extracted with ether (50 mL x 3). The combined organic extracts were washed with brIne (50 m(at)-) and dr*(at)–d, (sod.uTY: s.1l(at)a(at)e). After removal o4 the 3ci’.3(at)f:(at) t’e (at)3(at):::(at)(at) <";zs ;'.(at)-Z?"(at)'(at)(at)3(at) hy7 '(at):(at):1B(at)(at) xt(at)l:r- :-;(at)(at)(at)(at)(at).(at)5..t:;,?"£;:(at).;/ 8(at)(at)(at)0E. £ ,q], L .-.."I.: -'-(at)2(at)::'(at)0/;:/::*-(at),(at)(at) ::_=J'(at)(at)'(at)(at)- (J.>,’. ] .:: ilf=No.= (at):<.No...---'(at) (I? lflXJ i:.: ..:.:,i .::":.1 compound: (at)H-NMR (CDCl3) No. 8.51 (1 H, d, J=2.3 Hz), 8.41 (1 H, s), 7.09 (4H, d, J=6.2 Hz), 3.95 (3H, s) ; MS (ESI) m/z 374 (M + H)+. While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59782-86-4, 2-Chloro-5-iodonicotinic acid. Reference:
Patent; PFIZER PRODUCTS INC.; WO2005/102389; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 800401-70-1 ,Some common heterocyclic compound, 800401-70-1, molecular formula is C10H9BrN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

PdCl2 (PPh3) 2 (0.026g, 0.037mmol) and Cu (I) I (0.007g, 0. 037MMOL) were added sequentially to 5-BROMO-LH-PYRROLO [2,3-c] pyridine-2-carboxylic acid ethyl ester (Preparation 26, 0. 100G, 0.370mmol) under an argon atmosphere. 1,4-Dioxane (7mL, anhydrous) followed by DIISOPROPYLAMINE (0.063mL, 0. 45MMOL) were added and the stirred mixture was purged with argon for 5min. Trimethylsilylacetylene (0.064mL, 0. 45MMOL) was added dropwise and the resulting mixture stirred at rt for 24h. The reaction mixture was partitioned between water (50ML) and ethyl acetate (LOOML) and the layers separated. The aqueous phase was extracted with ethyl acetate (3X30ML). The combined organics were washed with brine (50ML), dried (MGS04), filtered and concentrated in vacuo. The residue was dissolved in the minimum amount of dichloromethane and loaded onto a silica column. Purification via flash column chromatography (SI02, dichloromethane then 25% ethyl acetate/ isohexane) gave a pale yellow solid. 8H (CDCl3): 0.28 (9H, s), 1.43 (3H, t), 4.45 (2H, q), 7. 18 (1H, s), 7.83 (1H, s), 8.86 (1H, s), 9.21 (1H, br s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 800401-70-1, Ethyl 5-bromo-1H-pyrrolo-[2,3-c]-pyridine-2-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; OSI PHARMACEUTICALS, INC.; WO2004/104001; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.57883-25-7, name is 3-Bromo-2-ethoxypyridine, molecular formula is C7H8BrNO, molecular weight is 202.05, as common compound, the synthetic route is as follows.COA of Formula: C7H8BrNO

To a solution of 465 3-bromo-2-ethoxy-pyridine (350 mg, 1.7 mmol) in NMP (2 mL) was added 423 Zn(CN)2 (244 mg, 2.1 mmol) and Pd(dppf)Cl2 (127 mg, 0.17 mmol). The mixture was degassed with N2 and heated at 140 C. under microwave irradiation for 1 hour. The mixture was cooled to room temperature and filtered through celite. The filtered cake was washed with ethyl acetate (30 mL). The filtrate was washed with water (20 mL×2) and brine (20 mL), dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography on silica gel (0%?20% 56 ethyl acetate in 57 petroleum ether) to give 467 2-ethoxynicotinonitrile.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,57883-25-7, 3-Bromo-2-ethoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; H. Lundbeck A/S; Juhl, Karsten; Jessing, Mikkel; Langgard, Morten; Vital, Paulo Jorge Vieira; Kehler, Jan; Rasmussen, Lars Kyhn; Clementson, Carl Martin Sebastian; Marigo, Mauro; (154 pag.)US2019/194189; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 597532-36-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 597532-36-0, name is Ethyl 6-(trifluoromethyl)nicotinate. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of ethyl 6-(trifluoromethyl)nicotinate (2.2 g, 10 mmol), Pd/C ( 10 wt.%, 100 mg) and platinum(IV)oxide (150 mg, 0.661 mmol) in acetic acid (30 mL) was stirred in a steel bomb under hydrogen atmosphere (200 psi) at 25 C for 24 hrs. The reaction mixture was filtered through a pad of celites and washed with MeOH (150 mL). The filtrate was concentrated under reduced pressure providing crude ethyl 6- (trifluoromethyl)piperidine-3-carboxylate (776 mg; mixture of cis and trans isomers) as a colorless oil, which was directly used in the next step without further purification.LCMS (m/z): 226.1 [M+H]+; Rt = 0.36 min.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 597532-36-0, Ethyl 6-(trifluoromethyl)nicotinate.

Reference:
Patent; NOVARTIS AG; PFISTER, Keith B; SENDZIK, Martin; WO2011/26917; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem