Tag: M.W:200-300

Adding a certain compound to certain chemical reactions, such as: 944900-06-5, 2-Chloro-6-(trifluoromethyl)nicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 944900-06-5, blongs to pyridine-derivatives compound. SDS of cas: 944900-06-5

General procedure: A mixture of 2-chloro-6-(trifluoromethyl)pyridine-3-carbaldehyde 13 (19.0 g, 90.8 mmol), Ti(OEt)4 (41.4 g. 182 mmol), and (S)-(-)-tert-butylsulfinamide (11.2 g. 92.6 mmol) in THF (200 mL) was stirred at reflux for 5 h. The cooled reaction mixture was concentrated, and dissolved in ethylacetate (500 mL). The resulting suspension was filtered through a Celite pad, and the filtrate was concentrated and purified by column chromatography (hexane/ EtOAc = 4 : 1) to provide the imine (28.9 g) as a light yellow solid. A mixture of the imine (28.9 g, 92.5 mmol), allyl bromide (55.9 g, 0.46 mmol), and indium (42.5 g, 0.37 mmol) was vigorously stirred in sat. NaBraq at room temperature overnight. After addition of sat. NaHCO3 aq (500 mL), the reaction mixture was extracted with ethylacetate (250 mL x 3). The organic layers were filtered through a Celite pad, and dried (Na2SO4), concentrated and purified by column chromatography (hexane/ EtOAc = 1 : 4 with 5 % of Et3N) to provide 17 as a white solid (26.0 g, 77 %).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,944900-06-5, 2-Chloro-6-(trifluoromethyl)nicotinaldehyde, and friends who are interested can also refer to it.

Reference:
Article; Matsufuji, Tetsuyoshi; Shimada, Kousei; Kobayashi, Shozo; Kawamura, Asuka; Fujimoto, Teppei; Arita, Tsuyoshi; Hara, Takashi; Konishi, Masahiro; Abe-Ohya, Rie; Izumi, Masanori; Sogawa, Yoshitaka; Nagai, Youko; Yoshida, Kazuhiro; Takahashi, Hisashi; Bioorganic and Medicinal Chemistry Letters; vol. 24; 3; (2014); p. 750 – 755;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1211532-15-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1211532-15-8, name is 6-Methoxy-5-(trifluoromethyl)nicotinic acid, molecular formula is C8H6F3NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

N,O-dimethylhydroxylamine hydrochloride (4.3 g), N-[3-(dimethylamino)propyl]-N?-ethylcarbodiimide hydrochloride(9.5 g), and N,N-diisopropylethylamine (30 mL) were added to a mixture of 6-methoxy-5-(trifluoromethyl)nicotinicacid (7.8 g) and methylene chloride (80 mL) under ice-cooling, and then the reaction mixture was stirred at room temperaturefor 17 hours. The reaction mixture was concentrated under reduced pressure, and to the residue were addedethyl acetate and water, followed by stirring for 30 minutes. The mixture was extracted with ethyl acetate, the organiclayer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residuewas purified by silica gel column chromatography (hexane-ethyl acetate) to N,6-dimethoxy-N-methyl-5-(trifluoromethyl)nicotinamide (5.0 g) as an oil.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1211532-15-8, 6-Methoxy-5-(trifluoromethyl)nicotinic acid.

Reference:
Patent; Astellas Pharma Inc.; TAKAHASHI, Taisuke; TANAKA, Hiroaki; AKAIWA, Michinori; NEGORO, Kenji; MIHARA, Hisashi; FUJI, Hideyoshi; TAKAMATSU, Hajime; (133 pag.)EP3196200; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 17570-98-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17570-98-8, name is 2-(Bromoacetyl)pyridine hydrobromide, molecular formula is C7H7Br2NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

B) Synthesis of 2- (pyridin-2-yl)-2-bromomethyl-4-hydrox methyl-1, 3-dioxolane cisltrans 316 ml of glycerol were dissolved in 2 1 of toluene and 13.6 g of p- toluenesulfonic acid and 195 g of 2-bromoacetyl-pyridine hydrobromide were added to this solution. The reaction mixture was refluxed for 24 hours, with removal of the water present in the azeotrope. Once the mixture had cooled to ambient temperature, 2 1 of 5% NaHCO3 were added, the two-phase mixture was stirred for 5 minutes and the phases were then separated. The aqueous phase was extracted six times with 600 ml of toluene, the organic phases were combined, dehydrated with Na2S04, and evaporated to dryness under reduced pressure, giving rise to 80 g of (cis/trans)-2-(pyridin-2-yl)-2-bromomethyl-4- hydroxymethyl-1,3-dioxolane (yield 42%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17570-98-8, 2-(Bromoacetyl)pyridine hydrobromide.

Reference:
Patent; ITALFARMACO S.P.A.; WO2005/40156; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1241752-31-7 ,Some common heterocyclic compound, 1241752-31-7, molecular formula is C8H10BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

a. Preparation of Compound A mixture of 5-bromo-2-ethoxy-3-methoxypyridine (279 mg, 1.0 mmol), 1-cyclohexenyl boronic acid pinacole ester (250 mg, 1.2 mmol), Pd(PPh3)4 (139 mg, 0.12 mmol) and K2C03 (277 mg, 2.0 mmol) in 1,4- dioxane (3.0 ml) and H20 (1.0 ml) was degassed for 30 min. This mixture was heated to 100 C and stirred for 16 h. The reaction mixture was cooled to room temperature and partitioned between NaHC03 and EtOAc (3x), and washed with NaCl (lx). The organic phase was dried over Na2S04 and was concentrated. The resulting residue was purified by ISCO flash chromatography using 10% EtOAc in hexane to give 551 mg (97%) of the desired product. NMR (300 MHz, CDC13) delta: 7.7 (s, IH), 7.04 (s, IH), 6.0 (m, IH), 4.4 (qt, 2H), 3.84 (s, 3H), 2.36 (m, 2H), 2.18 (m, 2H), 1.78 (m, 2H), 1.7 (m, 2H), 1.4 (t, 3H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1241752-31-7, 5-Bromo-2-ethoxy-3-methoxypyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; LAVOIE, Edmond J.; BAUMAN, Joseph David; PARHI, Ajit; SAGONG, Hye Yeon; PATEL, Disha; ARNOLD, Eddy; DAS, Kalyan; VIJAYAN, Suyambu Kesava; WO2014/43252; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 156094-63-2, 2-(Bromomethyl)-6-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 156094-63-2, blongs to pyridine-derivatives compound. name: 2-(Bromomethyl)-6-methoxypyridine

1.66 g (6.31 mmol) of triphenylphosphine and 685 mg (3.39 mmol) of 2-bromomethyl-6-methoxypyridine were mixed in 10 mL of benzene and heated up to 70 C under nitrogen atmosphere. The mixture was stirred in 25 hours, then cooled to ambient temperature. Theprecipitate was filtered and washed by 10 mL of benzene to give 1.47 g (3.17 mmol, 94 % yield) as awhite powder. The crude was used in the next reaction without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,156094-63-2, its application will become more common.

Reference:
Article; Kurihara, Seiya; Nishimura, Yoshinobu; Arai, Tatsuo; Bulletin of the Chemical Society of Japan; vol. 88; 7; (2015); p. 963 – 965;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1227384-81-7, name is 2-Bromo-5-(ethylsulfonyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H8BrNO2S

It can be manufactured by the method described in WO 2010/055004250 mg of 2-bromo-5- (ethanesulfonyl) pyridine,Bis (pinacolato) diboron 355 mg,[1,1′-bis (diphenylphosphino) ferrocene]Palladium (II) dichloride dichloromethaneAdduct 49 mg,A mixture of 294 mg of potassium acetate and 3 mL of dimethyl sulfoxide is stirred at 90 C. under a nitrogen atmosphere.After the reaction,The resulting mixture is filtered through Celite.The filtrate is concentrated under reduced pressure,2- (4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl) -5- (ethanesulfonyl) pyridine is obtained.

With the rapid development of chemical substances, we look forward to future research findings about 1227384-81-7.

Reference:
Patent; Sumitomo Chemical Chemicals company; Sasayama, Daisuke; Inui, Tomohiko; (102 pag.)JP2019/48845; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 62150-47-4, Ethyl 4-bromopicolinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 62150-47-4, blongs to pyridine-derivatives compound. Product Details of 62150-47-4

The second step: 8.5 kg of A was added to 35 liters of ammonia water in batches, methane was stirred overnight, and centrifuged to obtain a crude product which was washed with ethyl acetate and centrifuged to obtain 4.5 kg of amide;

At the same time, in my other blogs, there are other synthetic methods of this type of compound,62150-47-4, Ethyl 4-bromopicolinate, and friends who are interested can also refer to it.

Reference:
Patent; Chengdu Tong Chuangyuan Pharmaceutical Technology Co., Ltd.; Shou Yuehan; (12 pag.)CN105153023; (2018); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 943323-65-7 , The common heterocyclic compound, 943323-65-7, name is 4-Bromo-1H-pyrrolo[2,3-b]pyridin-3-amine, molecular formula is C7H6BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 4-bromo-1 H-pyrrolo[2,3-b]pyridin-3-amine (220 mg, 1.04 mmol)[prepared according to Example 89], 3-furoic acid (128 mg, 1.14 mmol) and diisopropylethyl amine (595 mul_, 3.42 mmol) in DCM (10 mL) at 25 C was added PyBrop (580 mg, 1.25 mmol) in one portion. After 12h, the solution was partitioned between H2O/DCM. The aqueous phase was washed several times with DCM and the combined organic fractions were dried over Na2SO4, concentrated and purified using column chromatography (silica, 3% MeOH in DCM) affording the title compound (290 mg, 91%) as an orange oil: LC-MS (ES) m/z = 307 (M+H)+.

The synthetic route of 943323-65-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/76423; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 67625-36-9, Ethyl 5-chloroimidazo[1,2-a]pyridine-2-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: Ethyl 5-chloroimidazo[1,2-a]pyridine-2-carboxylate, blongs to pyridine-derivatives compound. Recommanded Product: Ethyl 5-chloroimidazo[1,2-a]pyridine-2-carboxylate

Step 2. 5-Chloro-imidazo[1 ,2-a]pyridine-2-carboxylic acid ethyl ester (11.2 g) in concentrated hydrochloric acid (50 mL) and dioxane (50 ml_) was stirred under reflux overnight. The resulting solution was condensed under vacuum, washed with acetone and dried to obtain a solid, delta-chloro-imidazo?^-ajpyridine^-carboxylic acid (6.7 g). LCMS (m/z): 197.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,67625-36-9, Ethyl 5-chloroimidazo[1,2-a]pyridine-2-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; HIGH POINT PHARMACEUTICALS, LLC; MJALLI, Adnan, M.M.; HARI, Anitha; GADDAM, Bapu; GOHIMUKKULA, Devi, Reddy; POLISETTI, Dharma, R.; EL ABDELLAOUI, Hassan; RAO, Mohan; ANDREWS, Robert, C.; XIE, Rongyuan; REN, Tan; WO2010/126745; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58483-98-0, name is 2-Amino-5-bromonicotinamide, molecular formula is C6H6BrN3O, molecular weight is 216.04, as common compound, the synthetic route is as follows.Computed Properties of C6H6BrN3O

To a mixture of 2-amino-5-bromonicotinamide (200 mg, 0.93 mmol), thiophene- 2-carbaldehyde (125 mg, 1.11 mmol) in MeOH (15 mL) was added 4-methylbenzenesulfonic acid (16 mg, 0.09 mmol). The mixture was stirred at 60C overnight. Then the resulting solid was filtered to give the product of 6-bromo-2-(thiophen-2-yl)-2,3-dihydropyrido[2,3- d]pyrimidin-4(lH)-one (180 mg, yield: 63%), which was used for the next step without further purification. NMR (DMSO-ifc, 400 MHz) delta 8.93 (d, J= 2.4 Hz, 1H), 8.42 (s, 1H), 8.28 (d, J = 2.4 Hz, 1H), 7.98 (d, J= 2.4 Hz, 1H), 7.45 (dd, J= 4.8 Hz, 1.2 Hz, 1H), 7.08 (d, J= 3.2 Hz, 1H), 6.98 (dd, J= 4.8 Hz, 3.2 Hz, 1H), 6.10 (t, J= 2.4 Hz, 1H). MS (M+H)+: 310 / 312.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,58483-98-0, 2-Amino-5-bromonicotinamide, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey, C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/209727; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem