Tag: M.W:200-300

Electric Literature of 183483-29-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.183483-29-6, name is 2-(2-Bromopyridin-4-yl)acetic acid, molecular formula is C7H6BrNO2, molecular weight is 216.03, as common compound, the synthetic route is as follows.

c) (2-Bromo-pyridin-4-yl)-acetic acid ethyl esterTo a solution of (2-bromo-pyridin-4-yl)-acetic acid (60.0 g, 277.7 mmol) in ethanol (600 ml), conc: sulfuric acid (5.0 ml) was added at rt and the reaction mixture was heated at 90 C. for 9 h. Reaction mixture was cooled to rt and concentrated under reduced pressure to remove solvent completely. The residue obtained was cooled to 0 C. and pH was adjusted to 8 using 10% aqueous NaHCO3 solution. The resultant contents were worked up with ethyl acetate by washing with water, brine and dried over anhy. Na2SO4. Organic layer was concentrated under reduced pressure to obtain crude compound. Column chromtography purification of the crude compound using 15% ethyl acetate in hexane as eluent furnished title compound as a brown oil. Yield: 65.0 g (88.5%). TLC (30% ethyl acetate in hexane) Rf=0.39; LCMS: RtH7=0.824 [M+1]+=243.8 and 245.8; HPLC RtH9=3.759 min (69%); 1H NMR (300 MHz, CDCl3): delta 8.32 (t, 1H), 7.43 (s, 1H), 7.21-7.15 (M, 1H), 4.18 (q, 2H), 1.27 (t, 3H).

The chemical industry reduces the impact on the environment during synthesis 183483-29-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BADIGER, Sangamesh; CHEBROLU, Murali; HURTH, Konstanze; JACQUIER, Sebastien; LUEOEND, Rainer Martin; MACHAUER, Rainer; RUEEGER, Heinrich; TINTELNOT-BLOMLEY, Marina; VEENSTRA, Siem Jacob; VOEGTLE, Markus; US2012/184539; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 943323-65-7, Adding some certain compound to certain chemical reactions, such as: 943323-65-7, name is 4-Bromo-1H-pyrrolo[2,3-b]pyridin-3-amine,molecular formula is C7H6BrN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 943323-65-7.

To a solution of 4-bromo-1 H-pyrrolo[2,3-b]pyridin-3-amine (63 mg, 0.298 mmol) in dioxane (2.5 mL) and H2O (0.5 ml_) was added 1 ,1-dimethylethyl [3- phenyi-2-({[5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)-2- thienyl]carbonyl}amino)propyl]carbamate (145 mg, 0.298 mmol)[prepared inExample 87], Pd(PPh3)4 (17 mg, 14.9 mumol) and K2CO3 (164 mg, 1.19 mmol). After heating to 800C for 12h in a sealed tube, the reaction solution was partitioned between H2CVDCM. The aqueous phase was washed several times with DCM and the combined organic fractions were dried over Na2SO4, concentrated and purified using column chromatography (silica, 3% MeOH in DCM) affording the title compound (60 mg, 41 %) as an orange oil: LC-MS (ES) m/z = 492 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 943323-65-7, 4-Bromo-1H-pyrrolo[2,3-b]pyridin-3-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/76423; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 885326-88-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 885326-88-5, name is Methyl 6-amino-4-bromopicolinate. This compound has unique chemical properties. The synthetic route is as follows.

(5) Synthesis of methyl 6-(3-benzoylthioureido)-4-bromopyridine-2-carboxylate 2.74 g of methyl 6-amino-4-bromopyridine-2-carboxylate was dissolved in 15 ml of tetrahydrofuran and 1.63 ml of benzoyl isothiocyanate was added thereto, followed by stirring at room temperature for 13 hours. To the reaction mixture was added 40 ml of hexane. The resulting solid was filtered and washed with hexane. The obtained solid was dried in vacuo to give the title compound.

According to the analysis of related databases, 885326-88-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP2017279; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6318-51-0, name is (4-Chlorophenyl)(pyridin-2-yl)methanone, the common compound, a new synthetic route is introduced below. Computed Properties of C12H8ClNO

4-chlorophenylpyridylmethanone (43.5 mg, 0.2 mmol), dichlorantin (39.4 mg, 0.2 mmol) and Pd (OAc) 2 (4.5 mg, 0.02 mmol),2mL of dichloroethane was added, and the reaction was carried out at 90C for 12 hours. Purified by thin layer chromatography to obtain 25.2 mg of 2,4-dichlorophenylpyridylmethanone, yield 50.0%

The synthetic route of 6318-51-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; China Three Gorges University; Liu Qixing; Chen Yongsheng; Zhang Yin; Chen Danyi; Wen Simiaomiao; Zhao Rongrong; Liu Yiheng; Zhou Haifeng; (14 pag.)CN110563641; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 109306-86-7, name is 2-(2-Bromophenyl)pyridine. A new synthetic method of this compound is introduced below., Formula: C11H8BrN

To a solution of 2-(2-bromophenyl)pyridine (0.48 g, 2 mmol) in THF (10 mL) cooled with a dry ice-acetone bath was added dropwise a solution of n-BuLi in hexanes (1.3 mL, 1.6 M, 2.08 mmol, Aldrich) via a syringe. After the reaction mixture was stirred at -78 C. for 30 min, a solution of ZnCl2 in ether (2 mL, 1.0 M, 2 mmol, Aldrich) was added slowly via a syringe. The cooling bath was removed and the reaction mixture was warmed to ca 0 C. to room temperature. The bromide-bridged dimer [Ir(ppy)2Br]2 (0.58 g, 0.5 mmol) was added to the reaction mixture in one portion and the mixture was stirred for 30 min. Dichloromethane (10 mL) was added to accelerate the reaction. After stirring for ca. 1 hour at room temperature, the mixture was transferred into a one-necked flask and remaining yellow precipitates were washed into the flask with dichloromethane. The solvent was evaporated and the residue was dissolved in dichloromethane and purified by flash chromatography on silica gel with dichloromethane. The product was obtained as isomerically pure mer-(ppy)3Ir, 0.51 g, 78%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 109306-86-7, 2-(2-Bromophenyl)pyridine.

Reference:
Patent; Eastman Kodak Company; US6835835; (2004); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 77837-09-3 ,Some common heterocyclic compound, 77837-09-3, molecular formula is C13H11NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

6-Oxo-1-phenyl-1,6-dihydropyridine-3-carboxylic acid: Lithium hydroxide monohydrate (0.366 g, 8.73 mmol) was added to a mixture of methyl-6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate (1.0 g, 4.37 mmol), tetrahydrofuran (9 mL) and water (6 mL) at 0 C. The mixture was stirred for 1 hour, diluted with water and washed with ethyl acetate. The pH of the aqueous layer was adjusted to 2 using 2 N hydrochloric acid and the precipitate was filtered to give the title compound as a brown solid (0.740 g, 79%). m.p. 256-263 C.; 1H NMR (400 MHz, DMSO-d6) delta 6.53 (d, J=9.4 Hz, 1H), 7.40-7.49 (m, 5H), 7.87 (dd, J=2.5, 9.8 Hz, 1H), 8.23 (d, J=2.5 Hz, 1H); IR (KBr) nu 3446, 1708, 1645, 1577, 1263, 1228 cm-1; MS 214 (M-1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,77837-09-3, its application will become more common.

Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; US2008/319026; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 17117-17-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.17117-17-8, name is 3-Bromo-5-ethoxypyridine, molecular formula is C7H8BrNO, molecular weight is 202.05, as common compound, the synthetic route is as follows.

1-Benzyl-1,7-diazaspiro[4.4]nonane (500.0 mg, 2.4 mmol) was dissolved in dry toluene (15 mL) in a 50 mL round bottom flask equipped with a magnetic stirring bar. Nitrogen was bubbled through the solution in a slow stream. To the stirring solution was added 3-bromo-5-ethoxypyridine (513.8 mg, 2.55 mmol), potassium tert-butoxide (1039.0 mg, 9.26 mmol), rac-2,2′-bis(diphenylphosphino-1,1′-binaphthyl (86.4 mg, 0.14 mmol) and tris(dibenzylideneacetone)dipalladium(0) (63.6 mg, 0.06 mmol), while continuing to purge with nitrogen. Nitrogen flow was discontinued and the flask was sealed and heated at 90 C for 8 h. The reaction was cooled and the solvent was removed by rotary evaporation. The resulting residue was suspended in saturated aqueous sodium bicarbonate (10 mL) and extracted with chloroform (4 x 25 mL). The combined organic extracts were dried (Na2SO4), filtered, and concentrated by rotary evaporation to a thick dark mass. Purification by column chromatography, using methanol/chloroform (2:98, v/v) as the eluent, gave 0.54 g of the desired compound as a light brown viscous liquid (69 %).

The chemical industry reduces the impact on the environment during synthesis 17117-17-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; TARGACEPT, INC.; WO2004/5293; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 89978-52-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89978-52-9, name is Ethyl 2-bromoisonicotinate. This compound has unique chemical properties. The synthetic route is as follows.

Example 19; 2-(3-Cyano-4-phenylpyrrole-1-yl)isonicotinic acid ethyl ester; To a solution of 4-phenyl-1H-pyrrole-3-carbonitrile (0.1 g) in toluene (0.70mL) were added 2-bromo-isonicotinic acid ethyl ester (0.19 g), potassium phosphate (0.31 g), (1R,2R)-(-)-N,N’-dimethylcyclohexane-1,2-diamine (0.02 g) and copper iodide (0.007 g) at room temperature, and this mixture was stirred at 110C for 24 hours. The insoluble material was removed by filtration through Celite, and this filtrate was concentrated. This obtained residue was purified by column chromatography on silica gel (eluent: ethyl acetate/n-hexane = 10/90 – 66/34) to give the title compound (0.066 g).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 89978-52-9, Ethyl 2-bromoisonicotinate.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP2133331; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 55404-31-4, Adding some certain compound to certain chemical reactions, such as: 55404-31-4, name is 3-Bromo-2-chloro-4-methylpyridine,molecular formula is C6H5BrClN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55404-31-4.

Example 1Synthesis of 3-bromo-4-methylpyridin-2(1H)-oneTo a resealable pressure vessel charged with 3-bromo-2-chloro-4-picoline (1.200 g, 5.81 mmol) was added formic acid (13.1 ml, 348 mmol) and H2O (4.00 ml,.222 mmol). The tube was sealed and the solution heated to 1200C. After 72 hrs, the solution was cooled to RT and concentrated in vacuo. The residue was purified by reverse phase chromatography (neutral) to afford 3-bromo-4-methylpyridin- 2(1H)-one as a white solid. MH+ = 188.0.

According to the analysis of related databases, 55404-31-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMGEN INC.; WO2008/8493; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 132521-70-1, name is 6-(4-Methylpiperazin-1-yl)nicotinic acid, the common compound, a new synthetic route is introduced below. Safety of 6-(4-Methylpiperazin-1-yl)nicotinic acid

A mixture of 6-(4-methylpiperazin- 1 -yl)nicotinic acid (100 mg, 0.45 mmol), tert-butyl 2-amino-4-(thran-2- yl)phenylcarbamate (124 mg, 0.45 mmol) and EDCI (191 mg, 1 mmol) in pyridine (5 mE) was stirred at room temperature for overnight. The mixture was poured into water (20 mE) and extracted with EA to afford crude (270 mg, crude).

The synthetic route of 132521-70-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Regenacy Pharmaceuticals, LLC; van Duzer, John H.; Mazitschek, Ralph; (123 pag.)US2018/141923; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem