Tag: M.W:200-300

Adding a certain compound to certain chemical reactions, such as: 15862-50-7, 3-Bromo-2-methoxy-5-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 3-Bromo-2-methoxy-5-nitropyridine, blongs to pyridine-derivatives compound. Recommanded Product: 3-Bromo-2-methoxy-5-nitropyridine

A slurry of potassium carbonate (4.45 g, 32.2 mmol), potassium isopropenyltrifluoroborate (9b; 3.18 g, 21.46 mmol), PdCl2(AmPhos)2(0.152 g, 0.215 mmol), and 3-bromo-2-methoxy-5-nitropyridine (30b, 2.50 g, 10.73 mmol) in dioxane (50 mL) and water (20 mL) was sparged with nitrogen for 5 min, then placed in a sealed vessel and heated at 80 C for 1 h. The reaction mixture was then cooled to ambient temperature and partitioned between water and DCM. The organic layer was separated, and the aqueous layer was extracted with DCM (3×). The combined organic extracts were then dried over sodium sulfate, filtered, and concentrated in vacuo to give 2-methoxy-5-nitro-3-(prop-1-en-2-yl)pyridine (2.27 g, 11.69 mmol, >99% yield) as a red solid, which was used without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,15862-50-7, 3-Bromo-2-methoxy-5-nitropyridine, and friends who are interested can also refer to it.

Reference:
Article; Lanman, Brian A.; Reed, Anthony B.; Cee, Victor J.; Hong, Fang-Tsao; Pettus, Liping H.; Wurz, Ryan P.; Andrews, Kristin L.; Jiang, Jian; McCarter, John D.; Mullady, Erin L.; San Miguel, Tisha; Subramanian, Raju; Wang, Ling; Whittington, Douglas A.; Wu, Tian; Zalameda, Leeanne; Zhang, Nancy; Tasker, Andrew S.; Hughes, Paul E.; Norman, Mark H.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 24; (2014); p. 5630 – 5634;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 849068-61-7, Adding some certain compound to certain chemical reactions, such as: 849068-61-7, name is 5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid,molecular formula is C8H5BrN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 849068-61-7.

A mixture of 5-bromo-lH-pyrrolo[2,3-b]pyridine-3-carboxylic acid (480 mg, 2 mmol, 1.0 eq) and cone. H2S04 (0.5 mL, cat.) in methanol was refluxed for 24 h. After the reaction was complete, the solvent was concentrated. The resulting residue was dissolved with EA, washed with aq. NaHC03., dried over Na2S04, filtered and concentrated to provide methyl 5-bromo-lH-pyrrolo[2,3-b]pyridine-3-carboxylate (450 mg, 85%) as a white solid. LCMS (M+H+) m/z calculated 256.1 found 256.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 849068-61-7, 5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; QIAN, Shawn; (346 pag.)WO2018/11628; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 77332-79-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.77332-79-7, name is 3-Chloro-4-Iodopyridine, molecular formula is C5H3ClIN, molecular weight is 239.44, as common compound, the synthetic route is as follows.

(2) 3-Chloro-4-trifluoromethylpyridine was obtained from 3- chloro-4-iodopgammaridine by the method described in Eur. J. Org. Chem., (2004), 3793.

The chemical industry reduces the impact on the environment during synthesis 77332-79-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; WO2008/18639; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1155847-42-9, name is 2-Bromo-4-chloro-3-fluoropyridine. A new synthetic method of this compound is introduced below., SDS of cas: 1155847-42-9

Step-1: Preparation of tert-butyl (4-chloro-3-fluoropyridin-2-yl)carbamate To a solution of 2-bromo-4-chloro-3-fluoropyridine (825mg, 3.92mmol) in 1-4 Dioxane in a sealed tube (10ml) tert-butyl carbamate (505mg, 4.32mmol) and caesium carbonate (2.30g, 7.85mmol) and Pd(dba) (3350mg, 0.392mmol) and xanthphos (230mg, 0.392mmol) were added under argon and the reaction mixture was stirred at lOO C for 4h. The compound was extracted with ethyl acetate, dried over Na2S04 and concentrated to get crude compound which was purified by column chromatography using 20% EtOAC in hexane to obtain the title compound (450mg, 46.5%). LCMS: 63.4%, m/z = 247.0 (M+1)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1155847-42-9, 2-Bromo-4-chloro-3-fluoropyridine.

Reference:
Patent; GUMMADI Venkateshwar Rao; SAMAJDAR Susanta; WO2015/193846; A1; (2015);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 144584-32-7 , The common heterocyclic compound, 144584-32-7, name is 3-Bromo-2,4-dichloropyridine, molecular formula is C5H2BrCl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 96 2-Chloro-3-bromo-4-(cis-4-phenylcyclohexylamino)-pyridine 2.27 g (10 mmol) of 2,4-dichloro-3-bromopyridine, 2.6 g (15 mmol) of cis-4-phenylcyclohexylamine and 0.1 g of ammonium chloride are heated at 120 C. for 10 hours in 10 ml of N-methylpyrrolidone. After cooling, saturated sodium hydrogencarbonate solution is added and the reaction product is extracted with ethyl acetate. Purification is carried out by column chromatography. Yield: 1.9 g (52%); m.p. 105 C. 1 H-NMR (CDCl3): delta: 7.96 (d, 1H), 7.18 to 7.36 (m, 5H), 6.42 (d, 1H), 5.36 (d, 1H), 3.85 (m, 1H), 2.65 (m, 1H), 1.5 to 2.2 (m, 8H) ppm.

The synthetic route of 144584-32-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoechst Schering AgrEvo GmbH; US5723450; (1998); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 942189-65-3, 2-(6-Bromopyridin-3-yl)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 942189-65-3, blongs to pyridine-derivatives compound. SDS of cas: 942189-65-3

Example 31 To a stirred solution of 10 (3.05g, 12.9 mmol) in DMF (30 mL) 1 (5.97 mL, 38.7 mmol) and DIPEA (8.5 mL, 51.7 mmol) was added. The clear mixture was heated at 80 C overnight before concentrated to a small volume and partitioned between ethyl acetate and brine. The separated organic layer was dried and concentrated to dryness. The resulting crude was purified on silica gel column (eluting with 15% to 30% ethyl acetate in hexanes) to yield 11 as a brown solid (4.5 g, 84%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,942189-65-3, its application will become more common.

Reference:
Patent; SCHERING CORPORATION; ZHU, Hugh, Y.; DESAI, Jagdish, A.; COOPER, Alan, B.; DOLL, Ronald, J.; WO2011/41152; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 957187-27-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 957187-27-8, name is 8-Bromo-6-chloroimidazo[1,2-a]pyridine, molecular formula is C7H4BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

b) 8-(benzylthio)-6-chloroimidazo[1,2-a]pyridine A mixture of 8-bromo-6-chloroimidazo[1,2-a]pyridine (2.50 g), benzylmercaptan (1.40 mL), tris(dibenzylideneacetone)dipalladium(0) (248 mg), 1,1′-bis(diphenylphosphino)ferrocene (298 mg), DIPEA (3.8 mL) and toluene (20 mL) was stirred under a nitrogen atmosphere at 100 C. for 2 hr. The reaction mixture was filtered to remove an insoluble material and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (3.01 g). 1H NMR (300 MHz, DMSO-d6) delta 4.47 (2H, s), 7.13 (1H, d, J=1.8 Hz), 7.22-7.39 (3H, m), 7.39-7.47 (2H, m), 7.59 (1H, d, J=1.1 Hz), 7.93 (1H, d, J=1.2 Hz), 8.64 (1H, d, J=1.9 Hz).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 957187-27-8, 8-Bromo-6-chloroimidazo[1,2-a]pyridine.

Reference:
Patent; Takeda Pharmaceutical Company Limited; FUJIMOTO, Jun; LIU, Xin; KURASAWA, Osamu; TAKAGI, Terufumi; CARY, Douglas Robert; BANNO, Hiroshi; ASANO, Yasutomi; KOJIMA, Takuto; (159 pag.)US2019/169166; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 727356-19-6, name is 2-Bromo-6-(chloromethyl)pyridine, the common compound, a new synthetic route is introduced below. name: 2-Bromo-6-(chloromethyl)pyridine

2-Chloro-6-bromomethyl-pyridine was prepared from 2-chloro-6-methylpyridine [(638] mg, 5.0 mmol) with NBS (996.5 mg, 5.6 mmol) and AIBN (92 mg) in tetrachlorocarbon. [3-{5-] [[1- (6-CLROMO-PYRIDIN-2-YLMETHYL)-PIPERIDIN-2-YL]- [L,] 2,4] oxadiazol-3-yl}-benzonitrile (450 mg, quantitative) was obtained from [3- (5-PIPERIDIN-2-YL- [1,] 2,4] oxadiazol-3-yl) -benzonitrile (300 mg, 1.18 mmol) with crude 2-chloro-6-bromomethyl-pyridine (640 mg, 3.12 mmol) and diisopropylethylamine (762.5 mg, 5.0 mmol) in DMF (8 mL) at 80 [C] for [18] [H. IH] NMR [(CDC13),] [8] (ppm): 8.40 (d, 1H), 8.33 (dd, 1H), 7.79 (dd, 1H), 7.62 (q, 2H), 7.49 (d, [1H),] 7.18 (d, [1H),] 4.16 (t, [1H),] 3.75 (dd, 2H), 3.04 (m, [1H),] 2.49 (m, [1H),] 2.04 (m, 2H), 1.50-1. 86 (m, 4H).

The synthetic route of 727356-19-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2004/14902; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 84199-61-1, 3-Acetyl-2-bromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H6BrNO, blongs to pyridine-derivatives compound. Formula: C7H6BrNO

Synthesis of 7-phenylquinolin-5-ol (6.1) for Example 1[0271] 3-Acetyl-2-bromopyridine, 56 muL phenylacetylene, 170 muL DIPEA, 22.5 mg triphenylphosphinpalladium(II) chlorid, 3 mg Cu(I)I were suspended in 1 mL DMF under argon atmosphere and stirred for 16 h at 25 C. The mixture was diluted with DCM and extracted with diluted aq. NH3 and brine. The organic phase was concentrated and the mixture separated via flash chromatography (10 g SiO2, cyclohexane?cyclohexane/ethylacetate 70:30) to yield 40 mg 1-(2-(phenylethynyl)pyridin-3-yl)ethanone as solid. Analysis: HPLC-MS: Rt=1.21 min (method E), M+H=222

The synthetic route of 84199-61-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HOFFMANN, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KLICIC, Jasna; SCHAENZLE, Gerhard; WOLLIN, Stefan Ludwig Michael; CONVERS-REIGNIER, Serge Gaston; EAST, Stephen Peter; MARLIN, Frederic Jacques; McCARTHY, Clive; SCOTT, John; US2013/29949; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 90145-48-5, 5-Bromopyridine-2-carboxamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H5BrN2O, blongs to pyridine-derivatives compound. Formula: C6H5BrN2O

Description 9: 5-bromopicolinonitril D9)Phosphorus oxychloride (1 1 1 g, 0.720 mol) was added to a mixture of 5- bromopicolinamide (D8) (58 g, 0.288 mol) in dry toluene (300ml) The mixture was heated to reflux for 2 hours. The mixture was poured into ice/water, and basified to pH=12 with 2N NaOH. The resulting mixture was extracted with ethyl acetate and the organic phase was washed with brine, dried over Na2S04, and concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with a mixture petroleum ether/ethyl acetate 10:1 . Collected fractions, after solvent evaporation afforded the title compound (D9) (43.6 g) as a yellow solid.1 HNMR (400 MHz, CHLOROFORM-d) delta (ppm): 7.60 (d, J = 8.4 Hz, 1 H), 8.00 (dd, J = 6.0, 2.0 Hz, 1 H), 8.79 (d, J = 2.0 Hz, 1 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,90145-48-5, 5-Bromopyridine-2-carboxamide, and friends who are interested can also refer to it.

Reference:
Patent; ROTTAPHARM S.P.A.; BORRIELLO, Manuela; ROVATI, Lucio; STASI, Luigi Piero; BUZZI, Benedetta; COLACE, Fabrizio; WO2012/76063; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem