Tag: M.W:200-300

Related Products of 614750-84-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.614750-84-4, name is 6-Iodo-[1,2,4]triazolo[1,5-a]pyridine, molecular formula is C6H4IN3, molecular weight is 245.02, as common compound, the synthetic route is as follows.

To a solution of 6-iodo[l,2,4]triazolo[l,5-a]pyridme (5 g, 0.02 mol, prepared according to literature procedure) in anhydrous THF (300 mL), was slowly added IM of isopropylmagnesium bromide in THF (31 mL, 0.03 mol) at 0 oC. It was stirred at OoC for 1 hour and then was added anhydrous DMF (6 mL, 0.05 mol). It was allowed to warm to room temperature and stirred for overnight. It was then quenched with 100 mL of water and worked up with diethyl ether and saturated NaHCO3. Dried over MgSO4 and concentrated. The residue was purified on silica gel column with EtOAc to give the desire product as a tan solid (3g, 100percent). LC-MS/ES+: M+l: 148.0.

Statistics shows that 614750-84-4 is playing an increasingly important role. we look forward to future research findings about 6-Iodo-[1,2,4]triazolo[1,5-a]pyridine.

Reference:
Patent; BIOGEN IDEC MA INC; WO2006/26305; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 58530-53-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58530-53-3, name is 2,4-Dibromopyridine, molecular formula is C5H3Br2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 23 Synthesis of 1,1″-dihexyl-[4,2′:4′,4″-terpyridine]-1,1″-diium bis(tetrafluoroborate) A mixture of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (4.64 g, 22.6 mmol), 2,4-dibromopyridine (2.44 g, 10 mmol), Pd(PPh3)4 (0.59 g, 0.51 mmol, 5 mol %) and K2CO3 (3.12 g, 22.6 mmol) in degassed EtOH (50 mL) and PhMe (50 mL) under N2 was heated at reflux for 5 days, cooled, diluted with water (100 mL) and extracted with dichloromethane (4*75 mL). The dried (anhydrous sodium sulfate) solvent was removed in vacuo and the resulting brown powder chromatographed on silica, eluting with 5-10% MeOH in ethyl acetate. The solvent was removed to yield 4,2′:4′,4″-terpyridine as an off-white solid (2.07 g, 88.7%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 58530-53-3, 2,4-Dibromopyridine.

Reference:
Patent; Essilor International; ARCHAMBEAU, Samuel; BIVER, Claudine; BERIT-DEBAT, Fabien; AIKEN, Stuart; GABBUTT, Christopher David; HERON, Bernard Mark; BROADBENT, Thomas David; (37 pag.)US2018/194995; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 116387-40-7, name is Methyl 5-iodo-2-oxo-1,2-dihydropyridine-3-carboxylate. A new synthetic method of this compound is introduced below., Formula: C7H6INO3

c) Methyl 2-chloro-S-iodonicotinate. To a solution of anhydrous DMF (21.45 mL) and distilled POCl3 (26.13 mL) in anhydrous DCM (900 mL) was added methyl 2-hydroxy-5-iodonicotinate (39 g, 0.14 mol) in one portion. The mixture was stirred at room temperature for 28 hours under a N2 atmosphere. The solvent was removed under reduced pressure, and the residue was diluted with H2O. The pH of the aqueous solution was adjusted to pH = 8~9 with a saturated aqueous solution OfNaHCO3. The mixture was extracted with DCM (5 x). The combined organic layers were dried over Na2SO4 and filtered. The filtrate was evaporated under reduced pressure, and the oily residue was purified by silica gel column chromatography (1 : 10 EtOAc/hexanes) to give the title compound as a white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 116387-40-7, Methyl 5-iodo-2-oxo-1,2-dihydropyridine-3-carboxylate.

Reference:
Patent; AMGEN INC.; WO2008/130600; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 15471-17-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 15471-17-7, name is 3-(Pyridin-1-ium-1-yl)propane-1-sulfonate. This compound has unique chemical properties. The synthetic route is as follows.

Please refer to FIG. 2 and FIG. 3, which are a view showing reactions of fabricating the IL; and a view showing transacylation and stratification. As shown in the figures, on using the present invention, for fabricating an acidic IL as a catalyst, pyridine or 1-butyl-imidazole (N-butyl imidazole) is reacted with 1,3-propane sultone at 40 C. for 24 hrs to obtain a white solid of a zwitterionic compound. After being purified with ether and dried through vacuuming, the white solid of the zwitterionic compound of R+-(CH2)3-SO3- is obtained, where R is pyridine or 1-butyl-imidazole (i.e. n-propane sulfonic acid pyridinium (PSPy) or pyridinium propyl sulfobetaine (PPS)). An appropriate amount of the white solid is obtained in a round bottom flask to be added with a considerable number of moles of sulfuric acid for reaction with stirring at 100 C. for 0.5 hr. A transparent viscous liquid is gradually formed, which is an acidic IL of [R+-(CH2)3-SO3H][HSO4] obtained through the reaction shown in FIG. 2.

According to the analysis of related databases, 15471-17-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CPC CORPORATION, TAIWAN; Wu, Jung-Chung; Huang, Ming-Yu; Lin, Jann-Chen; Wang, Yih-Ping; (11 pag.)US9586886; (2017); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2,3-Dichloro-5-(trifluoromethyl)pyridine

1.82 kg of 3-chloro-2-chloro-5-trifluoromethylpyridine was dissolved in 27.231 L of methanol,Then 1.0119 kg of triethylamine was added thereto,Heated to reflux for 4 hours, and cooled to 20 C to obtain a reaction solution,The resulting reaction solution was filtered to obtain a filter cake,The resulting filter cake was vacuum dried at 40 C for 1 hour to obtain an organic salt; The organic salt obtained in step (1), 0.27 kg of hydrocyanic acid was added to 2.7 L of dichloromethane and 1.35 L of water,The reaction was stirred at 0 C for 3 hours to obtain a mixed solution, and the resulting mixture was allowed to stand at room temperature to obtain an organic phase a;The obtained organic phase a is added to hydrochloric acid to adjust its pH to 2 and then the layers are separated to obtain an acid water layer and an organic layer,The resulting organic layer was washed with water to a pH of 6 to give the washed water and the organic phase b; The organic phase b obtained in step is distilled at atmospheric pressure to 60 C and then distilled under reduced pressure,Collection of vacuum 2mmHg,The temperature of the ketone temperature of 70 to 120 C is 1.77 kg of 3-chloro-2-cyano-5-trifluoromethylpyridine,Yield 85.7%.

With the rapid development of chemical substances, we look forward to future research findings about 69045-84-7.

Reference:
Patent; Shandong Province Union Pesticide Industry Co., Ltd; Tang, Jianfeng; Pan, Guangmin; Li, Wenhong; Su, Jingchi; Zhao, Baoxiu; Liu, Jie; (9 pag.)CN106349159; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 14529-54-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 14529-54-5, name is 3,5-Dibromo-1-methylpyridin-2(1H)-one. A new synthetic method of this compound is introduced below.

Example 130a 5-Bromo-1-methyl-3-(1-methyl-1H-imidazol-4-ylamino)pyridin-2(1H)-one 130a A 100-mL single-neck round-bottomed flask equipped with a magnetic stirrer and a reflux condenser was charged with 1,4-dioxane (50 mL), 1-methyl-1H-imidazol-4-amine (1.1 g, 11.3 mmol), 3,5-dibromo-1-methylpyridin-2(1H)-one (3.0 g, 11.3 mmol), Pd2(dba)3 (1.0 g, 1.13 mmol), XantPhos (1.3 g, 2.26 mmol), and cesium carbonate (7.3 g, 22.6 mmol). After three cycles of vacuum/argon flush, the mixture was heated at 92 C. for 4.5 hrs. It was then cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure and the resulting residue was purified by silica-gel column chromatography eluting with dichloromethane/methanol (100:1 to 50:1) to afford 130a (2.4 g, 76%) as a yellow solid. MS-ESI: [M+H]+ 283.1

At the same time, in my other blogs, there are other synthetic methods of this type of compound,14529-54-5, 3,5-Dibromo-1-methylpyridin-2(1H)-one, and friends who are interested can also refer to it.

Reference:
Patent; GENENTECH, INC.; Crawford, James John; Ortwine, Daniel Fred; Wei, BinQing; Young, Wendy B.; US2013/116246; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 55304-72-8 , The common heterocyclic compound, 55304-72-8, name is 2,3,6-Trichloro-5-nitropyridine, molecular formula is C5HCl3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5,6-Chloro-iV-(5-cvclopropyl-l//-pyrazol-3-yl)-3-nitropyridine-2-amine To a solution of 2,3,6-trichloro-5-nitropyridine (1.62 g, 7.10 mmol) and DIEA (1.24 ml, 7.1 mmol) in THF (25 ml) was added dropwise a solution of 5-cyclopropyl-lH”-pyrazol-3- amine (0.70 g, 5.68 mmol) in THF (5 ml) at 0 0C. After addition, the reaction mixture was stirred at 25 0C for 24 hours. The solvent was removed under reduced pressure and the resulted residue was purified by column chromatography (hexane : EtOAc = 1.5 : 1) to give the title compound as a yellow solid (0.83 g, 47%). NMR (400 MHz) 12.39 (s, IH), 10.12 (s, IH), 8.77 (d, J= 1.2 Hz, IH), 6.35 (s, IH), 1.95 (m, IH), 0.96 (m, 2H), 0.71 (m, 2H). MS: Calcd.: 313; Found: [M+H]+ 314.

The synthetic route of 55304-72-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/87530; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 78607-36-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.78607-36-0, name is 2-Chloro-3-iodopyridine, molecular formula is C5H3ClIN, molecular weight is 239.44, as common compound, the synthetic route is as follows.

Example 1 :N-(2-(2,6-Dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl)cyclopropanecarboxamideStep 1 :2-Chloro-4-iodonicotinaldehydeA mixture of 2-chloro-3-iodopyridine (5.0 g, 21 mmol) in dry THF (30 mL) was slowly added to a cold (-78 C) solution of lithium diisopropylamide (15 mL, 30 mmol) in dry THF (50 mL). The resulting mixture was stirred for 3 h at this temperature. Ethyl formate (4.0 g, 54 mmol) was then added. Stirring was continued for 1.5 h at the same temperature. Water (10 mL) was added to quench the reaction, and then the resulting mixture was warmed to room temperature. 2M HC1 (50 mL) was added and then the THF was removed under reduced pressure. The aqueous residue was extracted with ethyl acetate (2 x 50 mL). The combined organic extracts were washed with brine, dried over Na2S04 and concentrated under reduced pressure. The residue was purified on silica gel (diethyl ether: petroleum ether = 1 : 4) to give the desired product 2-chloro- 4-iodonicotinaldehyde as a yellow solid (3.0 g, 54% yield). NMR (500 MHz, CDC13): delta 10.22 (s, 1H), 8.09 (d, J = 5.0 Hz, 1H), 7.95 (d, J = 5.0 Hz, 1H).

The chemical industry reduces the impact on the environment during synthesis 78607-36-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; GOODACRE, Simon; LAI, Yingjie; LIANG, Yun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong; WO2012/66061; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 78686-79-0, name is Methyl 5-bromo-2-chloronicotinate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: Methyl 5-bromo-2-chloronicotinate

Compound WX069-1 (7.00 g, 27.95 nmol) wasdissolved in dimethyl sulfoxide solution (50.00 mE) at roomtemperature, followed by the addition of cesium fluoride(8.00 g, 52.67 mmol) at room temperature. The reactionmixture was heated to 550 C. and stirred for 14 hours. Afterthe reaction, the mixture was cooled to room temperature,quenched with saturated brine (10 mE), diluted with water(50 mE) and extracted with ethyl acetate (20 mLx3). Thecolunm c1omatography (eluent: petroleum ether/ethylorganic phases were separated, washed with water (50mEx2) and dried over anhydrous sodium sulfate, followedby filtration. The filtrate was concentrated under reducedpressure. The obtained residue was isolated by silica gelacetate1 00/1 – 100/15, volume ratio) to obtain the targetproduct WX069-2. ?H NMR (400 MHz, CDC13) oe: 8.64-8.31 (m, 2H), 3.98 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 78686-79-0, Methyl 5-bromo-2-chloronicotinate.

Reference:
Patent; SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.; LUO, Yunfu; YANG, Chundao; LEI, Maoyi; LIU, LING; HU, Guoping; LI, Jian; CHEN, Shuhui; US2019/177318; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 78607-36-0, Adding some certain compound to certain chemical reactions, such as: 78607-36-0, name is 2-Chloro-3-iodopyridine,molecular formula is C5H3ClIN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 78607-36-0.

A mixture of 2-chloro-3-iodopyridine (400 mg , 1.67 mmol ), 2-methylpiperazine (200 mg, 2.0 mmol), sodium tert-butoxide (224 mg, 2.3 mmol), 9,9-dimethyl-4,5-bis(diphenyl- phosphino)Xanthen (48 mg, 0.08 mmol) and tris(dibenzylideneacetone) palladium (38 mg, 0.04 mmol) in toluene (6 mL) was heated at 110C for 18 hours. The mixture was poured out into water, extracted with EtOAc, the mixture was filtered through a short pad of Celite, the organic layer was separated, washed with water and brine, dried (MgS04), evaporated till dryness and the residue was carried out by flash chromatography over silica gel (grace, 40 g,CH2Cl2/MeOH/NH4OH 95/5/0.5) The pure fractions were collected and evaporated to dryness to afford 155 mg (44%) of intermediate (8).

According to the analysis of related databases, 78607-36-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JANSSEN R&D IRELAND; GUILLEMONT, Jerome Emile Georges; LANCOIS, David Francis Alain; MOTTE, Magali Madeleine Simone; LARDEAU, Delphine Yvonne Raymonde; BALEMANS, Wendy Mia Albert; ROYMANS, Dirk Andre Emmy; WO2015/14836; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem