Tag: M.W:200-300

Adding a certain compound to certain chemical reactions, such as: 6295-87-0, 1-Aminopyridinium Iodide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H7IN2, blongs to pyridine-derivatives compound. COA of Formula: C5H7IN2

General procedure: A clean, washed boiling tube equipped with a magnetic stir bar was charged with 1-aminopyridinium iodide (1a) (0.0665 g, 0.3 mmol),(E)-chalcone (2a) (0.0520 g, 0.25 mmol) and NMP (1 mL). The mixture was stirred for 24 h at r.t. under O2 (balloon). After completion of the reaction, the mixture was poured into hypo solution (10 mL). The mixture was extracted with EtOAc (3 × 10 mL), dried over anhydrous Na2SO4 and the solvent removed under reduced pressure. The residue was purified through column chromatography using silica gel (20%EtOAc/hexane) to afford 3a.

The synthetic route of 6295-87-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ravi, Chitrakar; Samanta, Supravat; Mohan, Darapaneni Chandra; Reddy, N. Naresh Kumar; Adimurthy, Subbarayappa; Synthesis; vol. 49; 11; (2017); p. 2513 – 2522;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 113975-22-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 113975-22-7, name is 2-Fluoro-3-iodopyridine, molecular formula is C5H3FIN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

NaO’Bu, 150C [00209] A microwave reaction vessel was charged with 2-fluoro-3-iodopyridine(purchased from Maybridge) (0.565 g, 2.53 mmol), morpholine (purchased from Aldrich) (0.221 ml, 2.53 mmol), Pd2(dba)3(purchased from Strem) (0.154 g, 0.152 mmol), 2- dicyclohexylphosphino-2′,6′-dimethoxy-l, -biphenyl (purchased from Strem) (0.135 g, 0.304 mmol), and sodium t-butoxide (0.8 g, 7.6 mmol). The reaction mixture was stirred and heated in a Discover model microwave reactor (CEM, Matthews, NC) at 150C for 20 min (125 watts, Powermax feature on, ramp time 5 min). Solvent was evaporated. The crude product was adsorbed onto a plug of silica gel and chromatographed through a Biotage pre-packed silica gel column, eluting with a gradient of 1% to 5% MeOH in CH2CI2, to provide 4-(2-fhioropyridin-3- yl)morpholine (0.311 g, 67.5% yield).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 113975-22-7, 2-Fluoro-3-iodopyridine.

Reference:
Patent; AMGEN INC.; ALLEN, Jennifer; HORNE, Daniel B.; HU, Essa; KALLER, Matthew R.; MONENSCHEIN, Holger; NGUYEN, Thomas T.; REICHELT, Andreas; RZASA, Robert M.; WO2011/143495; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 88511-27-7, 4-Amino-3-iodopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 88511-27-7, blongs to pyridine-derivatives compound. Recommanded Product: 88511-27-7

Step 2. To a 2 L 3-necked flask was added DMF (700 mL), triethylene diamine ( 168 g, 1 .5 mol), and 4-amino-3-iodopyridine (24, 1 10 g, 0.5 mol). The mixture was cooled with an ice-water bath and pyruvic acid (1 32 g, 1 .5 mol) was slowly added, followed by palladium acetate (4.49 g, 0.02 mol). Under nitrogen atmosphere, the mixture was heated to 1 15 C. The reaction generated effervescence. The reaction mixture was kept at 115- 120 C for 1 1 h, The mixture was concentrated under reduced pressure The residue was poured into water (500 mL), and concentrated HC1 was added to adjust pH to The above cake was added into 500 mL of water. Concentrated HCl was added (to ensure complete protonation) followed by 5 g of active carbon. The mixture was heated to reflux for 20 min and then filtration was performed while hot. The solid was discarded and the hot filtrate was placed in a refrigerator to allow the HCl salt of the desired product to precipitate. Upon cooling, filtration was performed which afforded a dark brown solid with a wet weight of 48 g as the HCl salt of the desired product. The solid was then added to 250 mL of water and the mixture was heated until a clear solution resulted. Solid NaOH was slowly added to adjust pH to 5-6, then active carbon and an addtional 500 mL of water was added. The mixture was heated to reflux for 30 min, then filtration was performed while hot. The resulting cake was added to 750 mL of water, heated to reflux, and filtered again. The cake thus obtained was discarded. The two batches of filtrate were combined and cooled in a refrigerator. The resulting precipitate was collected by vacuum filtration, then washed with ethanol to give the title compound as a slightly yellow solid (25 g, 31 %). MS (m/z, ES-): 161 . 1 [M-1], 323. 1 [2M-1]. 1H NMR (DMSO-d6, 400 MHz) delta 12.20 (br s, 1H), 8.97 (s, 1H), 8.27 (d, J = 5.6 Hz, 1 H), 7.41 (d, = 6.0 Hz, 1H), 7.23 (s, 1H).

The synthetic route of 88511-27-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Karl H.; DRAGOVICH, Peter; GOSSELIN, Francis; GUNZNER-TOSTE, Janet; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; ZAK, Mark; ZHANG, Yamin; ZHAO, Guiling; ZHENG, Xiaozhang; YUEN, Po-Wai; WO2013/127266; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 88511-27-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 88511-27-7, name is 4-Amino-3-iodopyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 3-iodopyridin-4-amine (6 g, 27.2 mmol) in dioxane (135 mL), (2,6-dichloropyridin-3-yl)boronic acid (7.29 g, 38.1 mmol), and 1M Na2CO3 aqueous solution (3 eq) were added andthe reaction mixture was degassed with argon for 20 mm. ThenBis(triphenylphosphine)palladium(ll) dichloride (3.79 g, 5.4 mmol) was added and the reactionmixture was heated at 100C for 16h. After completion of reaction, the reaction mixture wasfiltered through a celite pad and the filtrate was concentrated under reduced pressure to afford a residue that was dissolved in water and extracted with ethyl acetate. The organic layer was separated, dried over sodium sulphate and concentrated under reduced pressure to afford the crude product, which was further purified by silica gel (100:200 mesh) column chromatography toafford 2,6-dichloro-[3,3-bipyridin]-4-amine (ii) (2.9 g, Yield 44%).1H NMR (400 MHz, DMSO-d6) 66.04 (s, 2H), 6.62 (d, J= 5.8 Hz, 1H), 7.71 -7.55 (m, 1H), 7.94- 7.75 (m, 2H), 8.03 (d, J = 5.7 Hz, 1 H).MS (ESI) m/e (M+1): 240.05

According to the analysis of related databases, 88511-27-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UCB BIOPHARMA SPRL; MERCIER, Joel; VERMEIREN, Celine; (23 pag.)WO2018/24642; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 886365-02-2 , The common heterocyclic compound, 886365-02-2, name is 5-Bromo-4-methylpyridine-2-carboxylic acid, molecular formula is C7H6BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 5-Bromo-4-methyl-pyridine-2-carboxylic acid (650 mg, 3.0 mmol) in MeOH (2 ml) was added conc. H2SO4 (0.06 ml). The mixture was refluxed for 14 h, after which it was cooled to 0 C., neutralized with saturated NaHCO3, filtered, concentrated, and purified by column chromatography to give 5-Bromo-4-methyl-pyridine-2-carboxylic acid methyl ester (340 mg, 49%) as white solid.

The synthetic route of 886365-02-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoffmann-La Roche Inc.; Alam, Muzaffar; Bhagirath, Niala; Du Bois, Daisy Joe; Hawley, Ronald Charles; Minatti, Ana Elena; Kennedy-Smith, Joshua; Wilhelm, Robert Stephen; US2013/158040; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 13600-42-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 13600-42-5 as follows.

500 mL round bottom flask, 79.6 g (330 mmo 1) of 2,6-dichloro-3-cyano-4-(trifluoromethyl)pyridine concentrated sulfuric acid 400 grams heated to 100 degrees with stirring l h, after the reaction was added to the water to precipitate a solid, filtered and washed, dried to give a white solid 77 grams, yield 90.09%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13600-42-5, its application will become more common.

Reference:
Patent; Hebei Lan Tai Chemical Technology Co., Ltd.; Guo Ming; Meng Shuiqiang; Tian Penghui; Hou Jianjun; (14 pag.)CN107382848; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 66572-56-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 66572-56-3, name is 2-Bromoisonicotinic acid, molecular formula is C6H4BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 148; (E)-2-(2-(biphenyl-4-yl)vinyl)-N-hydroxyisonicotinamide; A. (£)-2-(2-(biphenyl-4-yl)vinyl)isonicotinic acid; 7>;alpha/?5-2-(4-biphenyl)vinylboronic acid (0.224 g, 1.00 mmol) and 2- bromoisonicotinic acid (0.202 g, 1 mmol) were combined and degassed/flushed with N2. The 1,4-dioxane (4 mL) and a solution of sodium carbonate (0.286 g, 2.70 mmol) in water (1 mL) were added. The mixture was degassed/purged with N2 again. The Pd(PPh3)4 (0.058 g, 0.05 mmol) was added. The mixture was degassed/purged with N2. The reaction mixture was heated to 100 0C overnight. After cooling to RT, aq 1 N HCl was added until the pH was 4. The resultant solid was collected and washed with several portions of water and washed once with ether to yield the title compound. LC-MS: [M+l]+ 302.1 Mass: Calculated for C20Hi5NO2, 301.34

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 66572-56-3, 2-Bromoisonicotinic acid.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BENENATO, Kerry, Ellen; CHOY, Allison, Laura; HALE, Michael, Robin; HILL, Pamela; MARONE, Valerie; MILLER, Matthew; WO2010/100475; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 52833-94-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52833-94-0, name is 2-Amino-5-bromonicotinic acid, molecular formula is C6H5BrN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 6-Chloro-1H-pyrido[2,3-d]pyrimidine-2,4-dione (4) (C7H4ClN3O2): The 2-amino-5-chloronicotinic acid 2 (5.96 g, 28.51 mol) was finely ground with urea (13.7 g, 228.1 mmol, 8 equiv). The mixture was heated to the point of evaporation of the urea (280C) by means of a sand bath until its solidification. After cooling, the solid obtained was dissolved in 500 mL of solution of sodium hydroxide (2 N) and filtered.Then, the filtrate was neutralized with hydrochloric acid solution (6N) to pH 8 until total precipitation of product. The resultant solid was filtered and then washed with cold water to obtain compound 4 as yellow solid in 64% yield.

According to the analysis of related databases, 52833-94-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Riadi, Yassine; Lazar, Said; Guillaumet, Gerald; Comptes Rendus Chimie; vol. 22; 4; (2019); p. 294 – 298;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 588729-99-1 ,Some common heterocyclic compound, 588729-99-1, molecular formula is C5H4BrClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 163; N-(6-(6-Chloro-5-(4-methoxyphenyIsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide; Step 1. N-(5-Bromo-2-chloropyridin-3-yl)-4-methoxybenzenesulfonamide; A solution of 4-methoxybenzenesulfonyl chloride (1 g, 5 mmol) and 3-amino-5-bromo-2-chloropyridine (0.45 g, 2 mmol) in 15 mL of pyridine was heated in a microwave vial at 100 C for 20 minutes. The mixture was then concentrated in vacuo and the residue was purified by a silica gel column chromatography to give first the di-sulfonamide compound (0.5 g, 42% yield): 1H NMR (300 MHz, chloroform -d) delta ppm 3.92 (s, 6 H) 6.94 – 7.09 (m, 4 H) 7.59 (d, J=2.34 Hz, 1 H) 7.81 – 7.98 (m, 4 H) 8.50 (d, J=2.34 Hz, 1 H); and then the mono-sulfonamide compound N-(5-bromo-2-chloropyridin-3-yl)-4- methoxybenzenesulfonamide (0.4 g, 49% yield): 1H NMR (300 MHz, chloroform -d) delta ppm 3.86 (s, 3 H) 6.84 – 7.06 (m, 3 H) 7.68 – 7.83 (m, 2 H) 8.08 – 8.21 (m, 2 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 588729-99-1, 3-Amino-5-bromo-2-chloropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AMGEN INC.; WO2009/17822; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 571188-59-5, Adding some certain compound to certain chemical reactions, such as: 571188-59-5, name is tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate,molecular formula is C14H22N4O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 571188-59-5.

600 mg of Compound 5 was dissolved in 3 mL of toluene solution. 2 mL of a 1 mol/L solution of LiHMDS in tetrahydrofuran was added at 0 to 10 C and stirred for 1 h. At 0 to 10 C, 292 mg of a toluene solution of Compound 2 was added, and the reaction was slowly returned to room temperature for 5 hours.After the end of the reaction was monitored by HPLC, the reaction was quenched with 6 mL of saturated ammonium chloride. The organic phase was separated and dried over anhydrous sodium sulfate. An off-white solid with a yield of 54%.

According to the analysis of related databases, 571188-59-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Suzhou Pengxu Pharmaceutical Technology Co., Ltd.; Li Pixu; Wang Peng; Wei Qiang; (7 pag.)CN109553621; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem