Tag: M.W:200-300

Electric Literature of 55304-75-1, Adding some certain compound to certain chemical reactions, such as: 55304-75-1, name is 2,6-Dichloro-3-(trifluoromethyl)pyridine,molecular formula is C6H2Cl2F3N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55304-75-1.

General procedure: A DMF/water solution (1:1, 2 mL per 1 mmol of 1) of K3PO4 (1.5 mmol), Pd(OAc)2(2 mol %), and arylboronic acid 2 (2.2 mmol) was stirred at room temperaturefor 8-12 h (tlc control). After completion of the reaction, the mixture wasextracted with CH2Cl2 and the combined organic layers were dried (Na2SO4), filtered and the filtrate was concentrated in vacuo. The residue was purified bycolumn chromatography (silica gel, EtOAc/heptane = 1:4). Starting with 1(216 mg, 1.0 mmol), K3PO4 (345 mg, 2.5 mmol), Pd(OAc)2 (2 mol %), arylboronic acid (334 mg, 2.20 mmol), and solution of DMF andwater (1:1) (2 mL), 4a-f was isolated as a yield.

According to the analysis of related databases, 55304-75-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ahmed, Shahzad; Sharif, Muhammad; Shoaib, Khurram; Reimann, Sebastian; Iqbal, Jamshed; Patonay, Tamas; Spannenberg, Anke; Langer, Peter; Tetrahedron Letters; vol. 54; 13; (2013); p. 1669 – 1672;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 799293-85-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 799293-85-9, name is 3-Bromothieno[3,2-c]pyridin-4-amine. A new synthetic method of this compound is introduced below.

To a solution of 3-bromo-thieno[2,3-c]pyridine-4-yl-amine (1.00 g, 4.38 mmol) in DMF (15 mL) was added NIS (1.08 g, 4.81 mmol). The resulting solution was stirred at room temperature overnight. Approximately half of the solvent was removed in vacuo and the resulting slurry was poured into sodium thiosulfate (5% solution in water, 100 mL). The resulting precipitate was collected and washed with water (2 x 30 mL) to afford 4-amino-7- biphenyl-3-yl-thieno[3,2-c]pyridine carboxylic acid as a tan solid (1.55 g, 4.38 mmol); RP- HPLC (Table 1, Method i) Rt 2.72 min; m/z: (M + H) + 357.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,799293-85-9, its application will become more common.

Reference:
Patent; ABBOTT LABORATORIES; WO2005/110410; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1136-52-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1136-52-3, name is (2,2,8-Trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of alpha4,3-O-isopropylidene pyridoxine (1, 0.10 g, 0.48 mmol, 1.00 eq.), 2,3,4,6-tetra-O-acetyl-[13C6]-alpha-d-glucopyranosyl bromide (24, 0.23 g, 0.57 mmol, 1.20 eq.) and molecular sieves (4 A) in dry dichloromethane (5 mL) was stirred under argon atmosphere at rt for 1 h. The reaction was cooled to 0 C, AgOTf (0.36 g, 1.43 mmol, 3.00 eq.) and NIS (0.32 g, 1.43 mmol, 3.00 eq.) were added and the reaction mixture was allowed to reach rt overnight. The mixture was diluted with dichloromethane (25 mL) and filtered through a pad of celite. Afterwards, the filtrate was washed with Na2S2O3 (10 % v/v in water, 30 mL) and the aqueous phase extracted with dichloromethane (3 x 40 mL). The combined organic layers were washed with distilled water (1 x 50 mL), brine (1 x 50 mL) and dried over Na2SO4. The solvent was evaporated under reduced pressure and the crude product subjected to column chromatography using SiO2 (pentane/ethyl acetate 1/1 to 1/4, gradient elution) followed by Sephadex (methanol, isocratic) to afford the glycoside (25, 85.8 mg, 0.15 mmol, 33 %).

According to the analysis of related databases, 1136-52-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Bachmann, Thomas; Schnurr, Christian; Zainer, Laura; Rychlik, Michael; Carbohydrate Research; vol. 489; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 30683-23-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 30683-23-9, name is 3-Bromopyridine-2-carboxylic acid, molecular formula is C6H4BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 5.45 g of 3-bromo-2-pyridine carboxylic acid (27.0 mmol, 1 eq.), obtained in example 3b), in 100 ml of methanol is reflux heated in the presence of 8 ml of sulfuric acid. The reaction mixture is allowed to return to ambient temperature and poured into water. It is extracted 3 times with ethyl acetate, the organic phase is dried on Na2SO4 and vacuum evaporated. 2.48 g (42%) of esterified product is obtained. NMR (1H, CDCl3): 4.02 (s; 3H), 7.34 (dd, J=8.2, 2.8 Hz; 1H), 8.04 (d, J=8.2 Hz; 1H), 8.64 (d, J=2.8 Hz; 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 30683-23-9, 3-Bromopyridine-2-carboxylic acid.

Reference:
Patent; Imbert, Thierry; Monse, Barbara; Koek, Wouter; US2005/80085; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 130284-53-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 130284-53-6, name is 5-Bromo-6-chloropyridin-3-amine, molecular formula is C5H4BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To the solution of 5-bromo-6-chloro-3-pyridinamine (0. 200g, 0.97 mmol) in 5 ml CH2CI2was added 3-phenylpropanal (0. 195 g, 1. 45mmol) followed by Na (OAc) 3BH (0. 411g, 1.94 mmol). The reaction mixture was stirred at room temperature for 1 h. The solution was quenched with water (5 mi) and product was extracted with CH2CI2 (5 mix3). The organic layer was dried over Na2SO4, concentrated. The compound was purified by flash column chromatography to give 0. 136g product (yield 50%).

According to the analysis of related databases, 130284-53-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/85227; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53937-02-3, name is 4-Benzyloxy-2-(1H)-pyridone, the common compound, a new synthetic route is introduced below. Recommanded Product: 4-Benzyloxy-2-(1H)-pyridone

tert-Butyl 7-bromo-5-methyl-3,4-dihydro-lH-pyrido[4,3-delta]indole-2(5H)-carbox- ylate (7.0 g, 19 mmol), 4-benzyloxypyridone (3.85 g, 19.2 mmol), K2CO3 (2.91 g, 21.1 mmol) and 8-hydroxyquinoline (418 mg, 2.88 mmol) were suspended in DMSO (50 mL) and the air removed under vacuum for 15 min. The system was then flushed with N2. This process was repeated and then copper iodide (547 mg, 2.88 mmol) was added. The evacuation/N2 flushing process was repeated twice more, and the reaction mixture was heated to 100-120 0C for 18 h. The mixture was cooled, partitioned between EtOAc and sat. NH4Cl and the organic phase removed, dried over Na2SO4, filtered and concentrated to dryness. Purification by flash column chromatography (silica gel, CH2Cl2/Me0H, 100:0 to 98:2 to 95:5 to 92:8 then 90:10) gave the title compound (4.71 g, 51%) as a yellow solid: 1H NMR (300 MHz, CDCl3) delta 7.50 (d, J= 8.2 Hz, IH), 7.43-7.35 (m, 5H), 7.32-7.29 (m, 2H), 7.01 (d, J= 7.9 Hz, IH), 6.10-6.03 (m, 2H), 5.06 (s, 2H), 4.64 (s, 2H), 3.89 (br t, 2H), 3.63 (s, 3H), 2.82 (br t, 2H), 1.50 (s, 9H).

The synthetic route of 53937-02-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ALBANY MOLECULAR RESEARCH, INC.; WO2009/89482; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 52833-94-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52833-94-0, name is 2-Amino-5-bromonicotinic acid, molecular formula is C6H5BrN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

PREPARATION 4 PREPARATION OF 5 -BROMO-3 ZOL-2-YL)PYRIDIN-2-AMINE To a suspension of 2-amino-5-bromopyridine-3-carboxylic acid (1.75 g, 8.09 mmol) and 2-amino-l-(3-chlorophenyl)ethanone hydrochloride (2.50 g, 12.1 mmol) in 100 mL of dichloromethane was added l-ethyl-3-(3- dimethylaminopropyl)carbodiimide (3.19 g, 16.2 mmol). The mixture was stirred at ambient temperature overnight to yield yellow precipitates. After filtration, the yellow precipitates were washed with dichloromethane to afford a yellow solid which was mixed with 10 mL of concentrated sulfuric acid and was stirred at ambient temperature for 20 hours. The reaction mixture was mixed with 40 mL of ice cold water and neutralized with ammonia solution to yield yellow precipitates. After suction filtration, the yellow precipitates were washed with water to afford 5 -bromo-3 -(5 -(3- chlorophenyl)oxazol-2-yl)pyridin-2-amine as an orange solid in 77% (2.00 g). 1H NMR (400 MHz, CDCI3): delta 8.27 (d, J = 2.4 Hz, 1H), 8.19 (d, J= 2.4 Hz, 1H), 7.71 (s, 1H), 7.65-7.57 (m, 1H), 7.55-7.45 (m, 1H), 7.45-7.33 (m, 2H), 6.78 (br s, 2H).

According to the analysis of related databases, 52833-94-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SIGNALCHEM LIFESCIENCES CORPORATION; ZHANG, Zaihui; WO2015/81257; (2015); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 934266-82-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.934266-82-7, name is 5-Bromothiazolo[5,4-b]pyridin-2-amine, molecular formula is C6H4BrN3S, molecular weight is 230.09, as common compound, the synthetic route is as follows.

Step 2: tert-Butyl 5-bromothiazolo[5,4-b]pyridin-2-ylcarbamate To a suspension of 5-bromothiazolo[5,4-b]pyridin-2-amine (15.0 g, 65.1 mmol) in DCM (300 mL) was added di-tert butyl dicarbonate (21.0 g, 96.2 mmol) and 4-dimethylaminopyridine (8 g, 65.5 mmol). The reaction mixture stirred at room temperature for 2 h and evaporated in vacuo. The residue was purified via flash chromatography on silica gel (solvent gradient: 0-50% ethyl acetate in petroleum ether) to yield 13 g (60%) of the title compound as a white solid. LCMS (ESI): [M+H]+=330/332.

Statistics shows that 934266-82-7 is playing an increasingly important role. we look forward to future research findings about 5-Bromothiazolo[5,4-b]pyridin-2-amine.

Reference:
Patent; Genentech, Inc.; Braun, Marie-Gabrielle; Garland, Keira; Hanan, Emily; Purkey, Hans; Staben, Steven T.; Heald, Robert Andrew; Knight, Jamie; Macleod, Calum; Lu, Aijun; Wu, Guosheng; Yeap, Siew Kuen; (183 pag.)US2018/65983; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.100367-40-6, name is 2-Amino-5-bromo-4-methyl-3-nitropyridine, molecular formula is C6H6BrN3O2, molecular weight is 232.04, as common compound, the synthetic route is as follows.name: 2-Amino-5-bromo-4-methyl-3-nitropyridine

This reaction was conducted under inert gas protection. The reaction vessel was first charged with 2000 ml methanol and cooled to about 0 C. with slight agitation. Then 9.1 kg acetyl chloride was added. The exothermic reaction was then cooled and agitated for 10 minutes. The next addition was 100 g 2-amino-5-bromo-3-nitro-4-picoline (the compound of formula 2 at 0 C. Then 236.5 g of t-butyl nitrite was added at a rate such that the temperature did not exceed 5 C. The slight evolution of nitrogen gas was noted. After the completion of the reaction, cooling was removed and the reaction mixture within the vessel was allowed to warm to 25 C. in about 30 minutes. The mixture was agitated at 25 C. for about 3-4 hours. After 4-5 hours a clear solution was obtained. Reaction completeness was monitored by HPLC after about 4 hours. The reaction was complete after about 5 hours. The reaction mixture was concentrated in vacuo to about 1000 mL. Then 500 ml of water was added and the product precipitated. Then 250 ml saturated sodium bicarbonate solution was added with good agitation to neutralize the HCl and dissolve the hydroxy impurity. The mixture was agitated at 20-25 C. for about 15 minutes and then the precipitate was collected and washed with 1000 ml of water. The product was then dried at 40 C. in vacuo. Yield was 75.0 g. Analytical data: m.p. 132 C. IR (KBr, cm-1): 1633, 1581, 1538, 1512, 1458, 1377, 1344, 1321, 1244, 869, 779. 1H-NMR (DMSO-d6) (delta, ppm): 2.31 (s, 3H), 3.96 (s, 3H), 8.55 (s, 1H): 13C-NMR (DMSO-d6) (delta, ppm): 17.49, 54.91, 99.41, 114.39, 141.02, 149.23, 153.46; HRMS calcd for C7H7BrN2O3 245.96401 found (M+1): 246.97184; Elemental Analysis: calcd for C7H7BrN2O3: C 34.03, H 2.85, N 11.34; found: C 33.81, H 2.91, N 11.24.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,100367-40-6, 2-Amino-5-bromo-4-methyl-3-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; Liu, Wansheng; Patel, Sunil S.; Cuniere, Nicolas; Lear, Yvonne; Deshpande, Prashant P.; Simon, Jeffrey N.; Lai, Chiajen; Pullockaran, Annie J.; Soundararajan, Nachimuthu; Bien, Jeffrey T.; US2007/32503; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5349-17-7, name is 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H7Br2NO

a) Preparation of Intermediate 24; A mixture of 2-bromo-1-(4-pyridinyl)-ethanone, hydrobromide (0.02 mol) and (5-chloro-2,4-dimethoxyphenyl)-thiourea (0.02 mol) in EtOH (200 ml) was stirred and refluxed for 4 hours, then cooled to room temperature. The resulting precipitate was filtered off, washed with EtOH and dried, yielding 6.0 g (60%) of intermediate 24 as a hydrobromide salt (.HBr).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5349-17-7, 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide.

Reference:
Patent; Thuring, Johannes Wilhelmus John F.; MacDonald, Gregor James; Grantham, Christopher James; Dinklo, Theodorus; Lesage, Anne Simone Josephine; US2011/269748; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem