Tag: M.W:200-300

Adding a certain compound to certain chemical reactions, such as: 82205-58-1, 1-(5-Nitropyridin-2-yl)piperazine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C9H12N4O2, blongs to pyridine-derivatives compound. HPLC of Formula: C9H12N4O2

To a stirred solution of 5-nitro-2-piperazinyl-pyridine (10.1 g) and potassium carbonate (20.29 g) in acetone (500 mL) was added portionwise 3-cyano-benzyl bromide (9.6 g) and the mixture was heated under reflux during 2 hours. The salts were removed by filtration, washed with acetone and the filtrate was evaporated to dryness. The residue was taken in CH2Cl2, and the solution washed with water, dried over Na2SO4, filtered and evaporated under reduced pressure to leave an oil which crystallized by trituration with diisopropyl oxyde. The title compound was obtained as a yellow solid (14.4 g). [0245] m.p.: 103-105 C.

The synthetic route of 82205-58-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dodic, Nerina; US2004/9988; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 882500-21-2, name is 5-Bromo-6-trifluoromethylpyridin-2-ylamine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C6H4BrF3N2

A mixture of 5-bromo-6-(trifluoromethyl)pyridin-2-amine (3.0 g, 12.3 mmol), Zn(CN)2 (0.81 g, 6.9 mmol), Pd2(dba)3 (0.57 g, 0.6 mmol), and Xantphos (0.72 g, 1.2 mmol) in DMA (12 mL) was placed in a sealed tube. The mixture was degassed with argon and stirred at 160C for 20h. The mixture was poured into water and extracted with EtOAc (2x). The combined organic layers were dried over magnesium sulfate and concentrated to dryness. The residue was purified by column chromatography on silica gel eluting with 3: 1 EtOAc/hexanes to afford 1.9 g of 6-amino-2-(trifluoromethyl)nicotinonitrile as a solid. lR NMR (400 MHz, CDC13) delta 7.74 (d, 1H), 6.67 (d, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 882500-21-2, 5-Bromo-6-trifluoromethylpyridin-2-ylamine.

Reference:
Patent; ARAGON PHARMACEUTICALS, INC.; SMITH, Nicholas, D.; BONNEFOUS, Celine; JULIEN, Jackaline, D.; WO2011/103202; (2011); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89570-82-1, name is 3-Chloro-2-hydrazinyl-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 3-Chloro-2-hydrazinyl-5-(trifluoromethyl)pyridine

A CEM-designed 10-mL pressure-rated vial was charged with POCl3(2 mL), 3-chloro-2-hydrazinyl-5-(trifluoromethyl)pyridine (211 mg,1mmol), 4-methoxylbenzoic acid or analogous acid (1mmol). The mixture was irradiated in a CEM Discover Focused Synthesiser (150 W, 140C, 200 psi, 15min). The mixture was cooled to room temperature by passing compressed air through the microwave cavity for 2 min. It was poured into cold ice (40 mL) and the formed precipitate filtered. The crude solid was recrystallised from EtOH to give the title compound 2a and others. All the other compounds were synthesised according to the same procedure.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 89570-82-1, 3-Chloro-2-hydrazinyl-5-(trifluoromethyl)pyridine.

Reference:
Article; Yang, Ming-Yan; Zhai, Zhi-Wen; Sun, Zhao-Hui; Yu, Shu-Jing; Liu, Xing-Hai; Weng, Jian-Quan; Tan, Cheng-Xia; Zhao, Wei-Guang; Journal of Chemical Research; vol. 39; 9; (2015); p. 521 – 523;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 84487-14-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 84487-14-9, name is 2-Bromo-3-nitropyridine-4-amine. A new synthetic method of this compound is introduced below.

To a solution of N1-(3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2- yl)phenyl)-N2,N2-dimethylethane-1,2-diamine (CVII) (2.00 g, 6.49 mmol, 1.2 eq), 2-bromo-3- nitropyridin-4-amine (CVIII) (1.18 g, 5.41 mmol, 1.0 eq), Na2C03 (1.15 g, 10.82 mmol, 2.0 eq) and Pd(dppf)Cl2 (395.73 mg, 540.83 muiotaetaomicron, 0.1 eq) in dioxane (40 mL) and H20 (8 mL) was degassed and then heated to 80C overnight under N2. TLC (PE:EtOAc=l : l) showed the starting material was consumed completely. The reaction mixture was poured into H20 (300 mL). The mixture was extracted with EtOAc (3 x 250 mL). The organic phase was washed with saturated brine (300 mL), dried over anhydrous MgSO i, concentrated in vacuum to give a residue, which was purified by silica gel column chromatography (PE/EtOAc=5/l) to afford N1-(3-(4-amino-3- nitropyridin-2-yl)-5-fluorophenyl)-N2,N2-dimethylethane-1,2-diamine (CIX) (1.50 g, 4.70 mmol, 86.9% yield) as a solid. ESIMS found for C15H18FN5O2 m/z 320.1 (M+H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,84487-14-9, 2-Bromo-3-nitropyridine-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; SAMUMED, LLC; KC, Sunil Kumar; WALLACE, David Mark; CAO, Jianguo; CHIRUTA, Chandramouli; HOOD, John; (322 pag.)WO2016/40193; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 171178-45-3, name is tert-Butyl (6-chloropyridin-3-yl)carbamate. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of tert-Butyl (6-chloropyridin-3-yl)carbamate

tert-Butyl(6-chloro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)pyridin-3- yl)carbamate. BuLi(2.166 mL, 5.70 mmol) was added to the diethyl ether (17 mL) solution of TMEDA(0.706 mL, 4.68 mmol) and tert-butyl (6-chloropyridin-3- yl)carbamate (0.4653g, 2.035 mmol) at -78 C. The reaction was stirred at this temperature for 1hour. Dihydro-2H-pyran-4(3H)-one (0.230 mL, 2.442 mmol) wasadded to the reaction mixture (at this moment, the bath temperature was -75C).The reaction was stirred for 2.5 hours before quenched with NH4CI (sat.). Thereaction was diluted with ethyl acetate and washed with water three times. Theorganic layer was separated, dried (Na2SC”4), filtered and concentrated.Flash column eluted with ethyl acetate in hexane from 0 to 25% to 50%> gavethe desired product (0.3600g, 45% yield, 83% pure). MS(ES+) m/e 329 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 171178-45-3, tert-Butyl (6-chloropyridin-3-yl)carbamate.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LUO, Guanglin; CHEN, Ling; DUBOWCHIK, Gene M.; JACUTIN-PORTE, Swanee E.; VRUDHULA, Vivekananda M.; PAN, Senliang; SIVAPRAKASAM, Prasanna; MACOR, John E.; WO2015/69594; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 884494-49-9, 2-Chloro-5-fluoro-4-iodopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-Chloro-5-fluoro-4-iodopyridine, blongs to pyridine-derivatives compound. name: 2-Chloro-5-fluoro-4-iodopyridine

General procedure: A reaction vial was charged with a mixture of the appropriate halide (1 equiv.), the organoboron reagent (1-3 equiv.), a Pd catalyst (0.05-0.1 equiv.) and an inorganic base (2-5 equiv.) in a mixture of water and 1 ,4-dioxane or toluene, as stated. The mixture was de gassed by evacuating and refilling with N2 three times or by bubbling N2 through for 5-15 min, then the reaction tube was sealed. The reaction was heated under the indicated conditions for the indicated time and allowed to cool to rt. Water or saturated NH4CI(aq) was added and the resulting mixture was extracted using DCM (x 3). The combined organic extracts were dried (phase separator), concentrated under reduced pressure and the remaining residue was purified by flash chromatography to give the product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,884494-49-9, 2-Chloro-5-fluoro-4-iodopyridine, and friends who are interested can also refer to it.

Reference:
Patent; ALMAC DISCOVERY LIMITED; ROUNTREE, James Samuel Shane; WHITEHEAD, Steven Kristopher; TREDER, Adam Piotr; PROCTOR, Lauren Emma; SHEPHERD, Steven David; BURKAMP, Frank; COSTA, Joana Rita Castro; O’DOWD, Colin; HARRISON, Timonthy; (333 pag.)WO2019/150119; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 67754-03-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.67754-03-4, name is Methyl 2,5-dichloronicotinate, molecular formula is C7H5Cl2NO2, molecular weight is 206.03, as common compound, the synthetic route is as follows.

Description 85: methyl 5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1- yl)nicotinate (D85)To a cooled (0C) solution of tert-butyl 3-((2,4-difluorophenyl)amino)azetidine-1 – carboxylate (D31 ) (90 mg, 0.316 mmol) in dichloromethane, a mixture of trifluoroacetic acid/dichloromethane (3ml/1 ml) was added and the reaction mixture was stirred 1 h. The solvents were evaporated in vacuo and the residue was dissolved in tetrahydrofuran/methanol (3/1 ml) triethylamine (0.132 ml, 0.95 mmol) was added followed by the addition of methyl 2,5-dichloronicotinate (52.33 mg, 0.253 mmol) and the resulting mixture was stirred 1 2h at 75 C. The residue abtained after solvent evaporation was purified by Biotage SNAP-Si column eluting with cyclohexane/ethyl acetate from 100/0 to 90/10. Collected fractions afforded the title compound (D85) (0022/086/5) (38 mg).MS: (ES/+) m/z: 354.1 [MH+] C16H14CIF2N302 requires 353.07.1 H NMR (400MHz ,CHLOROFORM-d) delta = 8.26 (d, J = 2.4 Hz, 1 H), 8.00 (d, J = 2.4 Hz, 1 H), 6.89 – 6.71 (m, 2 H), 6.47 (dt, J = 5.1 , 9.2 Hz, 1 H), 4.50 (dd, J = 7.3, 9.3 Hz, 2 H), 4.33 (br. s., 1 H), 4.12 (br. s., 1 H), 3.98 – 3.85 (m, 5 H)

Statistics shows that 67754-03-4 is playing an increasingly important role. we look forward to future research findings about Methyl 2,5-dichloronicotinate.

Reference:
Patent; ROTTAPHARM S.P.A.; BORRIELLO, Manuela; ROVATI, Lucio; STASI, Luigi Piero; BUZZI, Benedetta; COLACE, Fabrizio; WO2012/76063; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59281-14-0, name is 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one, the common compound, a new synthetic route is introduced below. SDS of cas: 59281-14-0

3 Oc) (2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)-methanolA solution of pyridinone (30b) (12.6 g) in water (1.4 1)containing sodium hydroxide (4.36 g) was hydrogenated over 10%palladium on charcoal (6.7 g) for 2 days. The mixture wasfiltered and the filtrate lyophilised.

The synthetic route of 59281-14-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MORPHOCHEM AKTIENGESELLSCHAFT FUeR KOMBINATORISCHE CHEMIE; WO2006/21448; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 86129-63-7, name is Ethyl 2,4-dichloro-6-methyl-3-pyridinecarboxylate, the common compound, a new synthetic route is introduced below. Formula: C9H9Cl2NO2

General procedure: To a solution of 2,4-dichloro-6-methylnicotinic acid ethyl ester (2.49 mmol) in 6 mL EtOH was added NaOEt (2.61 mmol). The reaction mixture was heated to 60C overnight in a closed vessel. At RT, the mixture was diluted with EtOAc and washed with aq. NH4CI solution. The organic layer was dried over MgS04 and concentrated in vacuo. Purification by (KP-SIL from Biotage) using Hept/EtOAc (1/1 ) gives the desired product as beige solid; LC-MS (C): tR = 0.83 min; [M+H]+: 244.13.

The synthetic route of 86129-63-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; HILPERT, Kurt; HUBLER, Francis; KIMMERLIN, Thierry; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon; WO2013/14587; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1659-31-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1659-31-0, name is Dipyridin-2-yl carbonate. A new synthetic method of this compound is introduced below.

General Procedure (1): A solution of (R)-2- Amino- 1-phenylethanol (0.675 g, 4.92 mmol) and di-2-pyridyl carbonate (1.06 g, 4.92 mmol) in anhydrous dichloromethane (50 ml) was stirred at RT overnight. The resultant reaction mixture was diluted with ethyl acetate (60 mL), washed with water (2×25 niL), brine (25 mL), dried over anhydrous sodium sulphate and concentrated in vacuo to get the product as a white solid. It was purified by chromatography on silica gel, eluting with 5-15 % ethyl acetate in hexanes, to yield 0.695 g (87 %) of the desired product as a white solid. 1H NMR (300 MHz, CDCl3): delta 7.42(m, 5H), 6.19 (bs, IH) 5.64 (t, IH), 4.0 (t, IH), 3.56 (dd, IH).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1659-31-0, Dipyridin-2-yl carbonate, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2007/78523; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem