Tag: M.W:200-300

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 108130-10-5, name is Ethyl 2,6-dichloro-4-methylnicotinate, the common compound, a new synthetic route is introduced below. Product Details of 108130-10-5

a) Synthesis of 6-chloro-2-(ethyl(methyl)amino)-4-methyl-pyridine-3-carboxylic acid ethylester A mixture of 8.2 g (35.0 mmol) 2,6-dichloro-4-methyl-pyridine-3-carboxylic acid ethylester, 3.7 ml (43.8 mmol) N-methylethylamine and 8.9 ml (52.5 mmol) DIPEA in NMP (25 ml) was heated in the MW to 90 C. for 1 h. Then the solution was diluted with water, a 1M aq. NaOH sol. and EtOAc. The organic layer was separated, dried over MgSO4 and concentrated in vacuo. Purification of the residue by CC (hexane/EtOAc 9:1) provided 4.0 g (15.6 mmol, 44%) 6-chloro-2-(ethyl(methyl)amino)-4-methyl-pyridine-3-carboxylic acid ethylester.

The synthetic route of 108130-10-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Grunenthal GmbH; US2012/101079; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 77837-08-2, name is 6-Oxo-1-phenyl-1,6-dihydropyridine-3-carboxylic acid. A new synthetic method of this compound is introduced below., Recommanded Product: 77837-08-2

General procedure: Method 3: [0050] After 300 mg (1.39 mmol) of 6-oxo-1-phenyl-1,6-dihydro-3-pyridinecarboxylic acid was dissolved in 10 mL of acetonitrile, 415 mg (2.08 mmol) of 3-aminoquinuclidine dihydrochloride and 718 mg (5.56 mmol) of diethylisopropylamide were added to the solution. Afterward, 207 mg (1.53 mmol) of 1-hydroxylbenzotriazole (HOBt) and 266 mg (1.39 mmol) of N-(3-dimethylaminopropyl)-N?-ethylcarbodiimide hydrochloride (EDC) were added to the reaction solution. This reaction solution was stirred at room temperature for about 24 hours. After termination of the reaction was determined by liquid chromatography, the solvent was removed in vacuo and then extracted three times with chloroform and an aqueous NaOH solution (pH=12), followed by purification using liquid chromatography (chloroform:methanol: ammonia water=10:1:0.1) to obtain a target compound (Actual yield: 317 mg, Percent yield: 70percent). [0051] 1H-NMR (CDCl3,200 MHz) delta8.11 (s, 1H), 7.75 (d, 1H), 7.40 (m, 4H), 6.65 (d, 1H), 6.26 (br, 1H), 4.15 (m, 1H), 3.39 (m, 1H), 2.89 (m, 4H), 2.53 (m, 1H), 2.06 (m, 1H), 1.53 (m, 4H)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 77837-08-2, 6-Oxo-1-phenyl-1,6-dihydropyridine-3-carboxylic acid.

Reference:
Patent; SK BIOPHARMACEUTICALS CO., LTD.; Maeng, Cheol Young; Jang, Young Koo; Cha, Su Bong; Shin, Hye Won; Joung, Chan Mi; Cha, Hwa Ryun; Yi, Eun Jung; US2013/317059; (2013); A1;,
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Application of 942947-95-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.942947-95-7, name is 2-Amino-5-bromo-4-chloro-3-nitropyridine, molecular formula is C5H3BrClN3O2, molecular weight is 252.45, as common compound, the synthetic route is as follows.

To a mixture of 5-bromo-4-chloro-3-nitro-pyridin-2-ylamine (0.126 g, 0.50 mmol) and isopropanol (9 ml) was added 1-[(2-pyridyl)-methyl]-piperazine (0.097 g, 0.55 mmol) followed by diisopropylethylamine (0.10 ml, 0.57 mmol). The reaction mixture was heated at 45 C. for 20 h, then allowed to cool to room temperature. The precipitate was collected by filtration and washed with isopropanol and diethyl ether. The title compound was thus obtained as a yellow solid (0.163 g, 83%); 1H-NMR (500 MHz, DMSO-d6) 2.57 (br s, 4H, piperazine N(CH2)2), 3.08 (br s, 4H, piperazine N(CH2)2), 3.65 (s, 2H, NCH2), 6.97 (s, 2H, NH2), 7.26 (ddd, J=7.45, 4.80, 1.00 Hz, 1H), 7.46 (d, J=7.80 Hz, 1H), 7.77 (td, J=7.66, 1.80 Hz, 1H) and 8.48 (dm, J=4.09 Hz, 1H) (pyrid-2-yl protons), 8.16 (s, 1H, 6-H);LC (Method B)-MS (ESI, m/z): Rt=2.00 min-393, 395 [(M+H)+, Br isotopic pattern].

Statistics shows that 942947-95-7 is playing an increasingly important role. we look forward to future research findings about 2-Amino-5-bromo-4-chloro-3-nitropyridine.

Reference:
Patent; THE INSTITUTE OF CANCER RESEARCH; US2009/247507; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 89284-11-7 ,Some common heterocyclic compound, 89284-11-7, molecular formula is C5H4Br2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 5,6-dibromopyridin-2-amine (9.50 g, 37.71 mmol) in methanol (100 mL) was added NaOMe solution (30% in MeOH, 100 g, 555.55 mmol) at room temperature. The resulting mixture was stirred for 1 h at 120 C. When the reaction was done, it was quenched by the addition of phosphate buffer solution (200 mL, pH = 7). The solids precipitated out from the resulting mixture were collected by filtration and dried under reduced pressure to yield 5-bromo-6-methoxypyridin-2-amine as orange solid (5.40 g, 71 %). MS: m/z = 202.8 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89284-11-7, its application will become more common.

Reference:
Patent; MERCK PATENT GMBH; KARRA, Srinivasa R.; XIAO, YuFang; SHERER, Brian A.; (380 pag.)WO2019/79373; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 67443-38-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 67443-38-3, name is 5-Bromo-2-chloro-3-nitropyridine, molecular formula is C5H2BrClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a 25 ml single-port round bottom flask were added 2-chloro-3-nitro-5-bromo pyridine (500 mg, 2.11 mmol) and methanol. The solution of sodium methoxide (228 mg, 4.22 mmol) in methanol was added into the flask. The reaction mixture was stirred at room temperature for 48 hours. The reaction was quenched with water and concentrated. The residue was extracted with ethyl acetate, dried with Na2SO4, and filtered to afford product 2-methoxy-3-nitro-5-bromo pyridine as a light yellow solid. [0205] 1HNMR (300 MHz, CDCl3): 8.502 (d, 1H) 8.302 (d, 1H) 4.113 (s, 3H); [0206] M+H: 233, 235

According to the analysis of related databases, 67443-38-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Astar Biotech LLC; Yu, Chunrong; Huang, Yong; US2014/38991; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1659-31-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1659-31-0, name is Dipyridin-2-yl carbonate, molecular formula is C11H8N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a suspension of sodium hydride, 60% in mineral oil (185 mg, 4.63 mmol) in THF (20 mL) was added 3-methyltetrahydrofuran-3-ol (394 mg, 3.86 mmol) at 0 C. After stirring 30 min, the solution was transferred to a solution of di(pyridin-2-yl)carbonate (834 mg, 3.86 mmol) in THF (20 mL) through a cannula. The formed slurry was stirred at 0 C. for 30 min. The slurry was warmed to rt and stirred for 2 h. The reaction was diluted with EtOAc, washed with brine, dried over MgSO4, filtered, concentrated to give a residue that was purified by Biotage (5-40% EtOAc:Hex) to afford the desired product 3-methyltetrahydrofuran-3-yl pyridin-2-yl carbonate (334 mg, 38.8% yield) as an oil.1H NMR (400 MHz, CHLOROFORM-d) delta 8.48-8.29 (m, 1H), 7.91-7.73 (m, 1H), 7.29-7.25 (m, 1H), 7.16-7.12 (m, 1H), 4.23 (d, J=10.3 Hz, 1H), 4.02 (td, J=8.5, 7.2 Hz, 1H), 3.95 (td, J=8.4, 4.5 Hz, 1H), 3.76 (d, J=10.3 Hz, 1H), 2.58-2.47 (m, 1H), 2.11-2.02 (m, 1H), 1.76 (s, 3H).

According to the analysis of related databases, 1659-31-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bristol-Myers Squibb Company; Hiebert, Sheldon; Rajamani, Ramkumar; Sun, Li-Qiang; Mull, Eric; Gillis, Eric P.; Bowsher, Michael S.; Zhao, Qian; Meanwell, Nicholas A.; Renduchintala, Kishore V.; Sarkunam, Kandhasamy; Nagalakshmi, Pulicharla; Babu, P.V.K. Suresh; Scola, Paul Michael; (403 pag.)US9527885; (2016); B2;,
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Pyridine | C5H5N – PubChem

Related Products of 113237-20-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 113237-20-0 as follows.

Example 20A 2-Chloro-5-fluoronicotinamide A suspension of 21.9 g (335.35 mmol) of zinc in methanol (207 ml) was admixed at RT with 44 g (210.58 mmol) of 2,6-dichloro-5-fluoronicotinamide. Acetic acid (18.5 ml) was then added, and the mixture was heated to reflux while stirring for 24 h. The contents of the flask were then decanted off from the zinc, and ethyl acetate (414 ml) and saturated aqueous sodium hydrogencarbonate solution (414 ml) were added, followed by extraction by vigorous stirring. Subsequently, the reaction mixture was filtered with suction through kieselguhr and washed through three times with ethyl acetate (517 ml each time). The organic phase was removed and the aqueous phase was washed with ethyl acetate (258 ml). The combined organic phases were washed once with saturated aqueous sodium hydrogencarbonate solution (414 ml), dried and concentrated under reduced pressure. Dichloromethane (388 ml) was added to the crystals thus obtained, and extraction was effected by stirring for 20 min. The mixture was once more filtered with suction, washed through with diethyl ether and sucked dry. Yield: 20.2 g (53% of theory) 1H NMR (400 MHz, DMSO-d6): delta=7.87 (br s, 1H), 7.99 (dd, 1H), 8.10 (br s, 1H), 8.52 (d, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,113237-20-0, its application will become more common.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Follmann, Markus; Stasch, Johannes-Peter; Redlich, Gorden; Ackerstaff, Jens; Griebenow, Nils; Knorr, Andreas; Wunder, Frank; Li, Volkhart Min-Jian; Baerfacker, Lars; Weigand, Stefan; US2014/148433; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 65-22-5 ,Some common heterocyclic compound, 65-22-5, molecular formula is C8H10ClNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: The synthetic routes for ligands (H3L1-2*Cl) are presented in Scheme 2. Pyridoxal N(4)-substituted thiosemicarbazone hydrochloride has been prepared according to a modification of the procedure described in the literature [25]. Substituted thiosemicarbazide (2 mmol) was dissolved in 10 mL of ethanol with constant stirring, and was added to pyridoxal hydrochloride (2 mmol) dissolved in 10 mL of ethanol. The mixture was stirred at 80 C for 30 min. After the reaction mixture was cooled to room temperature, the yellow solid was isolated by filtration, washed with ethanol and dried in vacuo.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 65-22-5, 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Manikandan, Rajendran; Vijayan, Paranthaman; Anitha, Panneerselvam; Prakash, Govindan; Viswanathamurthi, Periasamy; Butcher, Ray Jay; Velmurugan, Krishnaswamy; Nandhakumar, Raju; Inorganica Chimica Acta; vol. 421; (2014); p. 80 – 90;,
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Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 889865-45-6, name is 2,3-Dichloro-4-iodopyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 889865-45-6

A solution of 2-3-dichloro-4-iodopyridine(1.5 g, 5.47 mmol) in an aqueous solution of ammonia (25% w/w, 30 mL) washeated in a sealed tube at 130C for 8 hours. After cooling to roomtemperature, the reaction mixture was extracted with EtOAc (3 x 30 mL). Thecombined organic phases were washed with a saturated solution of brine (30 mL),dried over MgSO4,filtered and concentrated underreduced pressure. The residue was purified by chromatography on silicagel with Petroleum ether/Et2O(5:5) as eluent to afford 2l as a white solid (500 mg, 36% yield). Spectral data were inagreement with literature.

With the rapid development of chemical substances, we look forward to future research findings about 889865-45-6.

Reference:
Article; Silpa, Laurence; Niepceron, Alisson; Laurent, Fabrice; Brossier, Fabien; Penichon, Melanie; Enguehard-Gueiffier, Cecile; Abarbri, Mohamed; Silvestre, Anne; Petrignet, Julien; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 114 – 120;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 52833-94-0 ,Some common heterocyclic compound, 52833-94-0, molecular formula is C6H5BrN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4-[N’-(2-Amino-5-bromo-pyridine-3-carbonyl)-hydrazinocarbonyl]-piperidine-^ acid tert-butyl ester: To a solution of 2-amino-5-bromo-nicotinic acid (1.2 g, 5.53 mmol) in DMF (30 mL) were added 4-hydrazinocarbonyl-piperidine-l-carboxylic acid tert-butyl ester (1.5 g, 6.173 mmol), HATU (2.35 g, 6.184 mmol) and DIPEA (4 mL, 23.56 mmol) at RT. The reaction mixture was stirred for 18 h at RT. The reaction mixture was poured into ice-water (30 mL), extracted with ethyl acetate (3 X 50 mL), organic layer was washed with brine dried over anhydrous sodium sulphate concentrated under reduced pressure. Crude compound was purified by column chromatography using 100-200 mesh silica gel. The column was eluted with 60% EtOAc in petroleum ether to afford the title compound as an off- white solid. Yield: 1.3 g (53.19%) FontWeight=”Bold” FontSize=”10″ HNMR (DMSO-de, 400 MHz, TMS) delta: 10.32 (1H, s), 9.92 (1H, s), 8.20 (1H, s), 8.12-8.11 (1H, d), 7.2 (2H, s), 3.96-3.94 (2H, m), 2.77-2.69 (2H, m), 2.50-2.41 (1H, m), 1.73-1.70 (2H, m), 1.49-1.44 (2H, m), 1.40 (9H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,52833-94-0, its application will become more common.

Reference:
Patent; H. LUNDBECK A/S; VERNALIS (R&D) LTD.; MIKKELSEN, Gitte Kobber°e; DAVID, Laurent; WATSON, Stephen; SMITH, Garrick Paul; WILLIAMSON, Douglas Stewart; CHEN, I-Jen; WO2014/106612; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem