Tag: M.W:200-300

Application of 73290-22-9 , The common heterocyclic compound, 73290-22-9, name is 2-Bromo-5-iodopyridine, molecular formula is C5H3BrIN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

1-Ethynylferrocene (500 mg, 2.38 mmol) was dissolved in THF/TEA (20 mL, 1:1 v/v) and the solutionwas degassed (argon) for 10 minutes. 2-Bromo-5-iodopyridine (614 mg, 2.16 mmol),[Pd(CH3CN)2Cl2]2 (38 mg, 0.054 mmol) and CuI (41 mg, 0.216 mmol) were added and the mixture wasstirred at RT under inert atmosphere overnight. The reaction mixture was diluted with CH2Cl2 (50mL) and washed with EDTA/NH4OH(aq) (0.1 M, 100 mL). The organic layer was separated and theaqueous layer was extracted with CH2Cl2 (2 x 50 mL). The combined organic layers were washed withbrine (80 mL), dried over Na2SO4, filtered, and the solvent was removed under reduced pressure.Purification by column chromatography (silica gel, gradient 1:1 CH2Cl2/petrol to CH2Cl2 to 19:1CH2Cl2/acetone) gave the product as an orange crystalline solid upon removal of solvent. Yield: 0.776g, 98%.

The synthetic route of 73290-22-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Findlay, James A.; Barnsley, Jonathan E.; Gordon, Keith C.; Crowley, James D.; Molecules; vol. 23; 8; (2018);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 130115-85-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 130115-85-4, name is 5-Bromo-6-chloropyridin-3-ol, molecular formula is C5H3BrClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 13A tert-butyl (1S)-2-[(5-bromo-6-chloropyridin-3-yl)oxy]-1-(1H-indol-3-ylmethyl)ethylcarbamate A solution of 5-bromo-6-chloro-3-hydroxypyridine (2.50 g, 12 mmol) N-alpha-(tert-butoxycarbonyl)-L-tryptophanol (3.77 g, 18 mmol) and triphenylphosphine (4.72 g, 18 mmol) in THF (100 mL) was stirred at 0 C. for 20 minutes, treated with DEAD (2.83 mL, 18 mmol), stirred for 1 hour, warmed to room temperature, stirred for 15 hours, treated with ethyl acetate (300 mL), washed with brine, dried (MgSO4), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 25% ethyl acetate/hexane to provide the desired product (4.58 g, 80%). MS (APCI) m/e 480, 482 (M+H)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 130115-85-4, 5-Bromo-6-chloropyridin-3-ol.

Reference:
Patent; Li, Qun; Woods, Keith W.; Zhu, Gui-Dong; Fischer, John P.; Gong, Jianchun; Li, Tongmei; Gandhi, Virajkumar; Thomas, Sheela A.; Packard, Garrick K.; Song, Xiaohong; Abrams, Jason N.; Diebold, Robert B.; Dinges, Jurgen; Hutchins, Charles W.; Stoll, Vincent S.; Rosenberg, Saul H.; Giranda, Vincent L.; US2003/199511; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 65515-28-8, Adding some certain compound to certain chemical reactions, such as: 65515-28-8, name is Methyl 2,6-dichloronicotinate,molecular formula is C7H5Cl2NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 65515-28-8.

5-[2-(2-Chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-3-methyl-3H-benzooxazol-2-one (157 mg, obtained in Example 172) was added to a solution of methyl-2,6-dichloropyridine-3-carboxylate (81 mg, [CAS Reg. No. 65515-28-8]) in DMF (3 mL) followed by the addition of triethylamine (0.071 mL). Stirring was continued for 10 minutes at r.t. Then 1,4-diazabicyclo[2.2.2]octane (7 mg) was added. The mixture was stirred over night at r.t. The reaction mixture was poured into water, extracted with ethyl acetate and the organic layer was washed with brine, dried over Na2SO4 and evaporated. The residue was purified by flash chromatography (silica gel, gradient of heptane in ethyl acetate) to give the desired compound as a colorless foam (195 mg, 87%). MS (neg. ion, m/e)=569.2 [(M-H)-].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 65515-28-8, Methyl 2,6-dichloronicotinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hunziker, Daniel; Lerner, Christian; Mueller, Werner; Sander, Ulrike Obst; Pflieger, Philippe; Waldmeier, Pius; US2010/249124; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 5470-17-7, 3-Bromo-2-chloro-5-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5470-17-7, blongs to pyridine-derivatives compound. Recommanded Product: 3-Bromo-2-chloro-5-nitropyridine

Example 340: Preparation of 2-((3-bromo-5-nitropyridin-2-yl)(ethyl)amino)ethan-l-ol3- Bromo-2-chloro-5-nitropyridine (2 g, 8.42 mmol), triethylamine (1.174 ml, 8.42 mmol) and 2-(ethylamino)ethan-l -ol (0.751 g, 8.42 mmol) were mixed in Acetonitrile (30 ml). Heated to 80 C for 14 h and then concentrated. 1.76 g of product was recovered after automated chromatography on silica gel (DCM-EtOAc).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5470-17-7, its application will become more common.

Reference:
Patent; SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; YALE UNIVERSITY; SHAW, Reuben J.; EGAN, Daniel F.; COSFORD, Nicholas; TURK, Benjamin; VAMOS, Mitchell; PANICKAR, Dhanya Raveendra; CHUN, Matthew; SHEFFLER, Doug; (315 pag.)WO2016/33100; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 189281-66-1, Adding some certain compound to certain chemical reactions, such as: 189281-66-1, name is Methyl 2,6-dichloro-5-fluoronicotinate,molecular formula is C7H4Cl2FNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 189281-66-1.

Description 111Methyl 2-chloro-5-fluoro-6-methylnicotinate (Dl 11)FXQN CIA mixture of methyl 2,6-dichloro-5-fluoronicotinate (DuO, 6 g), 2,4,6-trimethyl-1,3,5,2,4,6- trioxatriborinane (3.36 g), K2C03 (9.99 g) and Pd(Ph3P)4 (1.548 g) in 1,4-dioxane (50 mL) was heated to 110C for 20 hours. The mixture was filtered, and the filtrate was concentrated. The residue was purified by column chromatography (silica gel, petroleum ether/EtOAc = 10:1) toafford the title compound (3.5 g) as yellow oil. MS (ES1): C8H7C1FNO2 requires 203; found 204[M+H].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 189281-66-1, Methyl 2,6-dichloro-5-fluoronicotinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DENG, Jing; LEI, Hui; MA, Xin; LIN, Xichen; WO2015/180612; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 102368-13-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.102368-13-8, name is 1,1′-Thiocarbonylbis(pyridin-2(1H)-one), molecular formula is C11H8N2O2S, molecular weight is 232.2584, as common compound, the synthetic route is as follows.

General procedure: Diisothiocyanate with various linker lengths (A6) were prepared according to publishedliterature.2 Commercially available diamine linkers (A5) were converted intodiisothiocyanate using TCDP (1,1?-thiocarbonyldi-2(1H)-pyridone) in single step processquantitative yield. To a solution of A6 (0.32 mmol) in dry pyridine (3 ml), A4 (15 mg,0.063 mmol) was added, followed by DMAP (catalyst amount) in CH2Cl2 (0.2 ml). Themixture was then stirred for 12 h. Volatiles were removed by reduced pressure. Themixture left was purified by column chromatography [0 to 2% methanol in CH2Cl2 (v/v)]to afford desired compound (84 – 92%).

Statistics shows that 102368-13-8 is playing an increasingly important role. we look forward to future research findings about 1,1′-Thiocarbonylbis(pyridin-2(1H)-one).

Reference:
Article; Watkins, Derrick; Gong, Changjun; Kellish, Patrick; Arya, Dev P.; Bioorganic and Medicinal Chemistry; vol. 25; 4; (2017); p. 1309 – 1319;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1018678-39-1, Adding some certain compound to certain chemical reactions, such as: 1018678-39-1, name is 4-Chloro-2-(trifluoromethyl)nicotinic acid,molecular formula is C7H3ClF3NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1018678-39-1.

A mixture of 4-chloro-2-(trifluoromethyl)nicotinic acid (1 .5 g, 6.65 mmol) in thionyl chloride (10.0 ml.) was stirred at 100C for 5 h. The reaction mixture was concentrated invacuo to afford the title compound (1 .60 g, Crude) Rf = 0.9 (5 % methanol in Dichloromethane).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1018678-39-1, 4-Chloro-2-(trifluoromethyl)nicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; JIRICEK, Jan; NG, Shuyi Pearly; RAO, Srinivasa P S; (126 pag.)WO2019/244049; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 66572-56-3, name is 2-Bromoisonicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Bromoisonicotinic acid

At 20 C,5.0 g of 2-bromopyridine-4-carboxylic acid (24.9 mmol, 1.0 eq), 4.46 g of CuCN (49.8 mmol, 2.0 eq), 50 mL of DMF was added to a 100 mL single-mouth bottle, replaced with nitrogen three times, and heated in an oil bath at 120 C for 18 h. The heating was stopped, cooled to room temperature, and most of the DMF was removed by rotary evaporation, poured into water, extracted with EA 200 mL three times, and the organic phase was washed twice with 50 mL of water and 20 mL of saturated sodium chloride. The organic phase is dried and dried to give a crude product. 2.0g crude product as a white solid after recrystallization from methanol,Yield: 54.2%.

With the rapid development of chemical substances, we look forward to future research findings about 66572-56-3.

Reference:
Patent; Jinan Shaoyuan Pharmaceutical Co., Ltd.; Shaoyuan Science And Technology (Shanghai) Co., Ltd.; Wang Haibo; Pan Tingting; Zheng Yan; (7 pag.)CN109836379; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 80194-68-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 80194-68-9, name is 3-Chloro-5-(trifluoromethyl)picolinic acid. A new synthetic method of this compound is introduced below.

(1) Add 1 g (1 mmol) of 3-chloro-5-trifluoromethylpicolinic acid and 5 ml of a solvent to a 50 ml single-neck round bottom flask,Add a few drops of the DMF mixture and stir for 10 min.Slowly add a mixture of 0.675 g (1.2 mmol) of oxalyl chloride and DCM. After the dropwise addition, stir at room temperature for 3 h and stop the reaction.The system was spin-dried to obtain intermediate 2;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,80194-68-9, its application will become more common.

Reference:
Patent; Guizhou University; Xu Fangzhou; Wu Jian; Luo Dexia; Guo Shengxin; He Feng; Zhang Renfeng; Chen Shunhong; (29 pag.)CN110526863; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 178876-82-9, name is Methyl 6-amino-5-bromopicolinate. A new synthetic method of this compound is introduced below., HPLC of Formula: C7H7BrN2O2

a) Methyl 3-oxo-3,4-dihydro-2H-pyrido[3,2-/?][1 ,4]thiazine-6-carboxylate A solution of ethyl 2-mercaptoacetate (1.473 mL) in DMF (48 ml_) was ice-cooled and treated with sodium hydride (540 mg of a 60% dispersion in oil). After 1 hour methyl beta-amino-delta-bromopyridine^-carboxylate (3 g) (T.R. Kelly and F. Lang, J. Org. Chem. 61, 1996, 4623-4633) was added and the mixture stirred for 16 hours at room temperature. The solution was diluted with EtOAc (1 litre), washed with water (3 x 300 mL), dried and evaporated to about 10 mL. The white solid was filtered off and washed with a little EtOAc to give the ester (0.95g); MS (APCI”) m/z 223 ([M-H]”, 100%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 178876-82-9, Methyl 6-amino-5-bromopicolinate.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/17468; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem