Tag: M.W:200-300

Adding a certain compound to certain chemical reactions, such as: 153034-82-3, 2-Fluoro-4-iodonicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Fluoro-4-iodonicotinaldehyde, blongs to pyridine-derivatives compound. Safety of 2-Fluoro-4-iodonicotinaldehyde

To a dry 15 mL ChemGlass pressure bottle under 2 was added (2,3,4- trifluorophenyl)hydrazine (359 mg, 2.212 mmol), 4-iodo-2-fluoro-3-formylpyridine (555.1 mg, 2.212 mmol), and anhydrous NMP (5 mL). The reaction mixture was flushed with argon, securely capped, and heated at 185C for 3h. The reaction mixture was worked up according to the procedure described in Intermediate 69A. The product was purified by Biotage Silica gel chromatography using a 25g Thompson Single Step silica cartridge with a linear gradient from 100% hexanes to 100% CH2CI2 over 12 column volumes gave 162.9 mg (20.4%) of the title compound as a yellow solid. LC/MS (Condition B): ret. T = 4.0 min, (M+H)+ 375.93.

The synthetic route of 153034-82-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; VELAPARTHI, Upender; FRENNESSON, David B.; SAULNIER, Mark G.; AUSTIN, Joel F.; HUANG, Audris; BALOG, James Aaron; VYAS, Dolatrai M.; WO2012/9510; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 524955-09-7, 3-Chloro-4-(pyridin-2-ylmethoxy)aniline, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 524955-09-7, blongs to pyridine-derivatives compound. Application In Synthesis of 3-Chloro-4-(pyridin-2-ylmethoxy)aniline

A mixture of N-(4-chloro-3-cyano-7-(2-methoxyethoxy)quinolin-6-yl)acetamide (6.3g, 0.0197 mol, 1.00 equiv), 3-chloro-4-(2-pyridylmethoxy)aniline (4.7g, 0.0201mol, 1.00 equiv), methanesulfonic acid (0.7ml, 0.0108 mol) and ethanol (150 ml) was stirred under refluxed for 6 hours and then 0.6N hydrogen chloride (300 ml, 0.18 mol) was added. The mixture was heated to 80 0C for 19 hours, and then cooled to 0 0C to form precipitate. The precipitated solids were filtered and then added to a solution of IN potassium carbonate (100ml, O.lmol) in methanol (150ml) and then the mixture was stirred for 3 hours. The resulting mixture was filtered, washed with 1 : 1 methano I/water (300ml) and dried to give product 6.4g. MS (ESI) m/z: 475 (M+l).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,524955-09-7, its application will become more common.

Reference:
Patent; MEDOLUTION LIMITED; ZHANG, Dawei; WO2010/151710; (2010); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 53937-02-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 53937-02-3, name is 4-Benzyloxy-2-(1H)-pyridone. This compound has unique chemical properties. The synthetic route is as follows.

Al l. Preparation of intermediate I- 11; 1-11 A mixture of 4-benzyloxy-2(lH)-pyridone (0.100 g, 0.50 mmol), 2-bromo-5-iodotoluene (0223 g, 0.75 mmol), CuI (0.048 g, 0.25 mmol), N,N’-dimethylethylenediamine (0.053 ml, 0.5 mmol) and K3PO4 (0.212 g, 1.0 mmol) in dioxane/DMF (4/1) was heated for 15 minutes at 180 0C in a microwave oven. Then DCM was added. The solid was filtered off through a CELITE pad and to the filtrate, a 32 % NH3 solution was added. The organic layer was separated, washed with brine, dried (Na2SO4), filtered and the solvent was evaporated. The residue was purified by column chromatography over silica gel (eluent: DCM). The product fractions were collected and the solvent was evaporated. The residue was treated with DIPE to yield intermediate compound 1-11 (0.130 g, 70 %).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 53937-02-3, 4-Benzyloxy-2-(1H)-pyridone.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2007/141200; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 153034-86-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 153034-86-7, name is 2-Chloro-4-iodopyridine. A new synthetic method of this compound is introduced below.

Step 1: 2-CHLORO-4-TRIMETHYLSILANYLETHYNYL-PYRIDINE 2-Chloro-4-iodo-pyridine (10.0 g, 41.8 mmol) was dissolved in 200 mL of dry THF and 17.5 mL of triethyl amine. This mixture was evacuated and backfilled with argon several times to remove oxygen from the solution. Triphenylphosphine (329 mg, 1.25 mmol) and bis (triphenylphosphine) palladium (II) chloride (1.47 g, 2.09 mmol) were added and the reaction mixture was stirred at room temperature for lh. Copper (I) iodide (239 mg, 1.25 mmol) and trimethylsilylacetylene (6.28 g, 6.39 mmol) were added. The reaction mixture was stirred at room temperature overnight. The solvent was evaporated. The residue was taken up in 500 mL of water and extracted three times with ethyl acetate (500 mL each). The combined organic extracts were dried with magnesium sulfate, filtered and evaporated. The crude product was purified by chromatography on silica gel (cyclohexane/ethyl acetate 80: 20). The desired product was obtained as a light brown semi solid (10 g, >100%). This material was used without any further purification for the next step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,153034-86-7, 2-Chloro-4-iodopyridine, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/3117; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 65515-32-4 ,Some common heterocyclic compound, 65515-32-4, molecular formula is C8H8ClNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 6-Chloro-2-methoxy-nicotinic acid methyl ester (18.5.0 g, 0.092 mol) in 50 mL of NMP was added p-methoxybenzylamine (19.0 g, 0.14 mol) and triethylamine (10.Og, 0.1 mol). The mixture was heated to 70 0C for 4 h, cooled and diluted with water and extracted with ethyl acetate, washed with water, brine, dried with sodium sulfate, and evaporated to get an oil which was precipitated with ethylacetate/hexane mixture (1 :1). This was then filtered and dried to yield 15 g (60 %) of the target compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,65515-32-4, its application will become more common.

Reference:
Patent; SCIOS, INC.; WO2006/112828; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 65515-28-8, Methyl 2,6-dichloronicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

A 250 mL eggplant flask was sequentially charged with methyl 2,6-dichloronicotinate (4.12g, 20 mmol), [1,1?-biphenyl]-4-phenol (3.40 g, 20 mmol), and 24 mL of N, N-dimethylformamide for dissolving them. Triethylamine (3.8 mL,26 mmol) was added dropwise under stirring at room temperature, and after completion of the dropwise addition, triethylenediamine (336 mg, 3 mmol) was added. The mixture was stirred at room temperature for 4-5 hours and the solutionchanged from clear to turbid. Thin layer chromatography [V (petroleum ether) / V (ethyl acetate) = 6/1] detected thatmost of the raw material disappeared. Then, 1.30 mL of HOAc, 25 mL of isopropanol and 15 mL of ice water weresequentially added while the solution changed from turbid to clear, and stirred at room temperature for 0.5 hour. 40mLof water was slowly dropwise added, and after completion of the dropwise addition, stirred at room temperature for 2hours. A large number of white solid precipitated and was filtered. The filter cake was washed with a mixed solution ofisopropyl alcohol / water = 1: 1 and dried under vacuum at 50 C for 8 hours to obtain 5.66 g of methyl 6-([1,1?-biphenyl]-4-oxo)-2-chloronicotinate as a solid, 83.24%

The synthetic route of 65515-28-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shenyang Sunshine Pharmaceutical Co., Ltd.; ZHOU, Yunlong; CAI, Suixiong; WANG, Guangfeng; JIAO, Lingling; MIN, Ping; JING, Yu; GUO, Ming; (44 pag.)EP3275881; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 65515-28-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.65515-28-8, name is Methyl 2,6-dichloronicotinate, molecular formula is C7H5Cl2NO2, molecular weight is 206.03, as common compound, the synthetic route is as follows.

step 1 (S ) -6-chloro-2- [1- (4-fluorophenyl) ethylamino] methyl nicotinatewas dissolved 2,6-dichloro-nicotinic acid methyl ester 5.0 g N, the N- dimethylformamide 50 ml, (S) – (-) – 1- (4-fluorophenyl) ethylamine 4.39 g, N, N-diisopropylethylamine 6.27g and 4-dimethylaminopyridine 150mg was added, and stirred for 24 hours at 60 C..The reaction mixture was cooled, diluted with ethyl acetate, washed successively with water and saturated brine, and dried over magnesium sulfate.Under reduced pressure, the solvent was distilled off, the resulting residue was purified by silica gel column chromatography to give the title compound 2.83g as a white powder.

Statistics shows that 65515-28-8 is playing an increasingly important role. we look forward to future research findings about Methyl 2,6-dichloronicotinate.

Reference:
Patent; NIPPON SHINYAKU COMPANY LIMITED; FUJIHARA, HIDETAKA; ASAKI, TETSUO; HORI, KATSUTOSHI; NAITO, HARUNA; (146 pag.)JP5668756; (2015); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 588729-99-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.588729-99-1, name is 3-Amino-5-bromo-2-chloropyridine, molecular formula is C5H4BrClN2, molecular weight is 207.4557, as common compound, the synthetic route is as follows.

(1) 5-bromo-3-amino-2-chloropyridine (0.10 g, 0.48 mmol),Pyridine (0.057g, 0.72mmol) was dissolved in dichloromethane (0.77mL) to prepare reaction solution 1, and phenylsulfonyl chloride (0.10g, 0.58mmol) was used to prepare reaction solution 2. The flow rate (0.4mL / min) set by the intelligent numerical control sampler was simultaneously introduced into the first three-way mixer (ambient temperature 0 C) through a 500 mum inner diameter picker tube and mixed, and then flowed out under its own pressure and entered In a temperature-controlled (25 C) picker tube with an inner diameter of 500 mum, the sulfonamidation reaction is completed under the condition of a set residence time t1 (1min), and then the post-pressure valve is used to obtain a first effluent;

The chemical industry reduces the impact on the environment during synthesis 588729-99-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Fudan University; Zhuhai Fudan Chuangxin Institute; Ling Yun; Zhou Yaming; Jia Yu; Deng Mingli; Liu Xiaofeng; Yang Yongtai; Chen Zhenxia; (30 pag.)CN110498798; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 15862-31-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15862-31-4, name is 3-Bromo-5-nitropyridin-2-amine, molecular formula is C5H4BrN3O2, molecular weight is 218.01, as common compound, the synthetic route is as follows.

Compound 1 (2.6 g, 12.52 mmol) and iodo benzene (2.5 g,13.77 mmol )were dissolved in Toluene( 25 m) and the solution was degassed with argon. Palladium acetate (0.28 g, 6.26 mmol ) ,xanthaphos (0.545 g, 1.252 mmol) , sodium tertiary butaoxide(l .65 g, 18.78 mmol )were added. The reaction was heated at reflux under argon for 2h.The solvent was removed in vacuum and crude mass was purified by column chromatography by eluting with 20percent ethyl acetate in pet ether to get desired compound 2 ( 1 g )

Statistics shows that 15862-31-4 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-5-nitropyridin-2-amine.

Reference:
Patent; VITAS PHARMA RESEARCH PRIVATE LIMITED; RANGARAJAN, Radha; KUMAR, Rajinder; PRABHAKAR, B V; CHANDRASEKHAR, P; MALLIKARJUNA, P; BANERJEE, Ankita; WO2013/42035; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1609373-99-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1609373-99-0, name is 2-Methyl-8-(pyridin-2-yl)benzofuro[2,3-b]pyridine, molecular formula is C17H12N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediate I-3 (3.9 g, 5.2 mmol) and ligand L-2 (3.8 g, 15.6 mmol)Dissolved in DMF (100 mL) and 2-ethoxyethanol (100 mL)The mixture was heated at 130 C for 18 hours.After evaporating the solvent, the crude product contains 65-100%The hexane eluent of dichloromethane is purified by column.GD-003 (2.5 g, yield: 60%) was obtained.

According to the analysis of related databases, 1609373-99-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zhejiang Huaxian Optoelectric Technology Co., Ltd.; Zheng Xianzhe; Wang Shichao; Hu Congcong; Wu Xinwei; Zhao Xiaoyu; (158 pag.)CN109810146; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem