Tag: M.W:200-300

Related Products of 15862-36-9 ,Some common heterocyclic compound, 15862-36-9, molecular formula is C5H2Br2N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

B. 2-(3-Methoxyphenyl)-5-nitro-3-phenylpyridineObtained (0.257 g, 87% of yield) following the procedure described in Intermediate 2 (step A) starting with 3-bromo-2-(3-methoxyphenyl)-5-nitropyridine (0.97 mmol, 0.300 g) and phenylboronic acid (1.07 mmol, 0.130 g).ESI/MS (m/e, %): 307 [(M+1)+, 100].C. 2-(3-Methoxyphenyl)-5-nitro-3-phenylpyridineObtained (0.258 g, yield 87%) following the procedure described in Intermediate 27, starting with 3-bromo-2-(3-methoxyphenyl)-5-nitropyridine (0.97 mmol, 0.300 g), phenylboronic acid (1.07 mmol, 0.130 g). delta 1H NMR (300 MHz, CDCI3): 3.64 (s, 3H), 6.89-6.99 (m, 3H), 7.21-7.24 (m, 3H), 7.32- 7.37 (m, 4H), 8.50 (s, 1 H), 9.47 (s, 1 H). ESI/MS (m/e, %): 307 [(M+1)+, 100].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15862-36-9, its application will become more common.

Reference:
Patent; LABORATORIOS ALMIRALL, S.A.; WO2009/21696; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 78607-36-0 , The common heterocyclic compound, 78607-36-0, name is 2-Chloro-3-iodopyridine, molecular formula is C5H3ClIN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-chloro-3-iodopyridine (500 mg, 2.09 mmol) was placed under argon and dissolved in anhydrous 9 THF (10 ml). 10 Et3N (1.44 ml, 5 eq, 10 mmol) and 11 1-ethoxy-4-ethynylbenzene (365 mg, 1.2 eq, 2.5 mmol) were added, followed by 12 CuI (10 mg, 0.025 eq, 0.05 mmol) and 13 PdCl2(PPh3)2 (37 mg, 0.025 eq, 0.05 mmol). The dark brown mixture was stirred at r.t. for 3 h, before 14 water (20 ml) and 15 CH2Cl2 (20 ml) were added. The aqueous layer was extracted with CH2Cl2 and the organic extracts were washed with water and brine, dried over MgSO4 and concentrated. The crude product was purified by flash chromatography (PE:EtOAc 85:15) to afford the desired 26 compound (440 mg, 82%). 1H-NMR (300 MHz, CDCl3): 1.43 (t, J=7.0 Hz, 3H), 4.06 (q, J=7.0 Hz, 2H), 6.87 (d, J=8.8 Hz, 2H), 7.22 (dd, J=7.7, 4.8 Hz, 1H), 7.49 (d, J=8.8 Hz, 2H), 7.82 (dd, J=7.7, 1.9 Hz, 1H), 8.31 (dd, J=4.8, 1.9 Hz, 1H).

The synthetic route of 78607-36-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Institut National de la Sante et de la Recherche Medicale (INSERM); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite Claude Bernard Lyon 1; Dimanche-Boitrel, Marie-Therese; Bach, Stephane; Delehouze, Claire; Goekjian, Peter; Comte, Arnaud; (32 pag.)US2018/312502; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 127561-18-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 127561-18-6, name is 1-(6-(Trifluoromethyl)pyridin-2-yl)piperazine. A new synthetic method of this compound is introduced below.

A-9 (0.33g, 1.40mmol), C-1 (0.30g, 1.30mmol),Triethylamine Anhydrous(0.263 g, 2.60 mmol) was dissolved in 25 mL of anhydrous acetonitrile, and HATU (0.513 g, 1.40 mmol) was added, and the reaction was performed at room temperature for 30 min. After the reaction, it was diluted with water, extracted with ethyl acetate, washed with dilute hydrochloric acid, washed with sodium bicarbonate solution, washed with saturated brine, dried over anhydrous sodium sulfate, filtered, concentrated and purified by silica gel column chromatography (PE: EA = 2: 1, v / v) to obtain 470.385 g of the compound with a yield of 66.6%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,127561-18-6, 1-(6-(Trifluoromethyl)pyridin-2-yl)piperazine, and friends who are interested can also refer to it.

Reference:
Patent; Hangzhou Weitan Pharmaceutical Technology Co., Ltd.; Cheng Yunfeng; Hu Yongzhou; (45 pag.)CN110357833; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1050501-88-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1050501-88-6, name is 2-Bromo-6-chloropyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows.

Step 2: synthesis of 5-chloro-1H-pyrrolo[3,2-bjpyridine-2-carboxylic acid (intermediate 20b)2-oxopropanoic acid (36.22 g, 411.31 mmol), palladium(II)acetate (7.74 g, 34.15 mmol) and Et3N (69.11 g, 682.94 mmol) were added to a solution of 2-bromo-6- chloropyridin-3-amine 20a (32.20 g, 155.21 mmol) and TPP (35.83 g, 136.59 mmol) in dry DMF (300 ml). The reaction mixture was stirred at 100C overnight. The solvent was then evaporated, water was added and the water layer was washed with EtOAc.The water layer was acidified with conc. HC1. The precipitate was filtered off and dried, yielding 25.21 g of the wanted product 20b (82.6 %). m/z = 197.1 (M+H), Cl pattern.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1050501-88-6, 2-Bromo-6-chloropyridin-3-amine.

Reference:
Patent; JANSSEN R&D IRELAND; TAHRI, Abdellah; VENDEVILLE, Sandrine Marie Helene; JONCKERS, Tim Hugo Maria; RABOISSON, Pierre Jean-Marie Bernard; HU, Lili; DEMIN, Samuel Dominique; COOYMANS, Ludwig Paul; WO2014/60411; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 110651-92-8, 7-Chloro-6-nitrothieno[3,2-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 110651-92-8, blongs to pyridine-derivatives compound. category: pyridine-derivatives

A mixture of 7-chloro-6-nitrothieno[3,2-b]pyridine (381 mg, 1.78 mmol), [(1R,2R,4S)-4-amino-2-methoxycyclohexyl]acetonitrile (racemic) (310 mg, 1.8 mmol) and N,N-diisopropylethylamine (1.2 mL, 7.1 mmol) in isopropyl alcohol (4.2 mL) was heated at 90 C. for 2 h. The crude was concentrated and purified with flash chromatography to give the desired product (485 mg, 78%). LCMS calculated for C15H19N4O3S (M+H)+: m/z=347.1. Found: 347.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,110651-92-8, its application will become more common.

Reference:
Patent; Incyte Corporation; Li, Yun-Long; Zhu, Wenyu; Mei, Song; Glenn, Joseph; US2014/121198; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 175205-81-9, name is 2-Bromo-4-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-Bromo-4-(trifluoromethyl)pyridine

General procedure: To a solution of 4-amino-l-((tr<3i)-3-(benzyloxy)cyclobutyl)-lH-pyrazolo[3,4- d]pyrimidin-3-ol (3) (200 mg, 642 mumol,, 1 eq) in DMSO (10 mL) was added 2-bromo-4- (trifluoromethyl)pyridine (IB) (233 mg, 1.28 mmol, 2 eq) and IGCO3 (178 mg, 1.28 mmol, 2 eq) and the mixture was stirred at 125°C for about 3 h. The mixture was filtered and the filtrate was purified by prep-HPLC (TFA condition) to give l -((trans)-3- (benzyloxy)cyclobutyl)-3-((4-(trifluoromethyl)pyridin-2-yl)oxy)-l H-pyrazolo[3,4- d]pyrimidin-4-amlne (4) (150 mg, 263 mumol, 40.9percent yield) as a white solid. With the rapid development of chemical substances, we look forward to future research findings about 175205-81-9. Reference:
Patent; VYERA PHARMACEUTICALS, LLC; WASHINGTON UNIVERSITY; HOPPER, Allen, T.; SIBLEY, L., David; JANETKA, James, W.; HELANDER, Jon; (149 pag.)WO2019/36001; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5349-17-7, name is 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H7Br2NO

Preparation of 2-Methyl-5-nitro-phenyl)-(5-pyridin-4-yl-oxazol-2-yl)-amineTo a solution of 4-bromoacetylpyridine hydrobromide (5 g, 17.8 mmol) in 😯 mL of water was added sodium azide (1.16 g, 17.8 mmol) and the contents stirred at room temperature for 30 min. The reaction mixture was cooled to O0C, treated slowly with saturated aqueous NaHCO3 until pH=6-7, extracted with dichloromethane (3×3 OmL) and the combined organic phases were dried over MgSO4, concentrated at room temperature under reduced pressure to a final volume of 25 mL, and diluted with dioxane (30 mL). The resulting solution was concentrated to remove the remaining EPO (lower boiling) dichloromethane. To the final volume (25 mL) was added at O0C, 2- methyl-5-nitrophenyl isocyanate (1.58 g, 8.9 mmol) (commercially available) and portion wise triphenylphosphine (2.62 g, 8.9 mmol). The reaction mixture was then stirred for 1 h at room temperature and heated for an additional 2 h at 100C. After evaporation of the solvent under reduced pressure the residue was crystallized in dichloromethane/ethanol (10mL/5mL), to give the title compound as yellow crystals (0.9 g, 34%). m p > 220 C

With the rapid development of chemical substances, we look forward to future research findings about 5349-17-7.

Reference:
Patent; AB SCIENCE; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS); INSTITUT CURIE; WO2006/106437; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 84703-18-4, name is 5-Bromo-2-chloro-6-methylnicotinonitrile, molecular formula is C7H4BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 84703-18-4

Step 1: 5-bromo-2-chloro-6-methylnicotinaldehyde (119b) To a solution of 5-bromo-2-chloro-6-methylnicotinonitrile (0.20 g, 0.86 mmol) in DCM (200 mL) was successively added DIBAL (0.86 mL, 1.30 mmol) at -78 C. under N2. The reaction mixture was stirred at room temperature for 2 h. the mixture was diluted with water and EtOAc. The organic layer was separated and the aqueous layer extracted with EtOAc. The residue was purified by column chromatography on silica gel to give 119b (20.0 g, 60.4%) as a yellow solid. LC-MS (ESI): m/z=233.9 [M+H]+

With the rapid development of chemical substances, we look forward to future research findings about 84703-18-4.

Reference:
Patent; Fronthera U.S. Pharmaceuticals LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; LI, Yao; (169 pag.)US2019/367515; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.571188-59-5, name is tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate, molecular formula is C14H22N4O2, molecular weight is 278.35, as common compound, the synthetic route is as follows.Application In Synthesis of tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

To the three-necked flask added tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate (30.62 g, 110 mmol), 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (29.28 g, 100 mmol), sodium tert-butoxide (14.42 g, 150 mmol) and dimethylacetamide (293 mL), stirred evenly, cooled to 0 ~ 5 C vacuum switching nitrogen protection, BrettPhos Pd G3 (418 mg, 0.5 mmol) was added, and after the addition was completed, the temperature was raised to 105 to 110 C for 6 to 8 hours. After end of the reaction was cooled to room temperature, a saturated aqueous ammonium chloride solution (293 mL) was added to quench the reaction. The aqueous phase was extracted 3 times with ethyl acetate (146 mL). The organic phase was washed once with saturated brine (146 mL). dry over sodium sulfate, filter through celite, concentrate and add ethanol and petroleum ether. slurry, filter to separate the solid, drying in vacuo to give the compound tert-butyl 4-(6-((7-cyclopentyl-6-(dimethylaminoformyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate (41.17 g, 77%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,571188-59-5, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; Hangzhou Kechao Biological Technology Co., Ltd.; Yu Wei; Zhang Yiping; (21 pag.)CN108586356; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 152460-10-1, name is N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C16H15N5

1,4-Dioxane (75 ml) and thionyl chloride (45.5 ml) were added to p-toluic acid (25 g) and the mixture was heated at 60C for 12 hours. The resulting mass was distilled under vacuum at 50C to produce an oily mass. The resulting oil was slowly added to a stirred suspension of (45.8 g), potassium carbonate (63 g), tetrahydrofuran (238 ml) and N-(5- Amino-2-methylphenyl)-4-(3-pyridinyl)-2-pyrimidineamine at 0C. The resulting mass was stirred for 3 hours at 25C and followed by quenching in a mixture of water (700 ml) and ethyl acetate (92 ml). The resulting mixture was stirred for 2 hours at 25 C and filtered the solid. The solid was washed with water (400 ml) and ethyl acetate (200 ml), and dried in an air oven at 65C for 8 to 10 hours to give 47.5 g of 4-methyl-N-[4-methyl-3-[[4-(3- pyridinyl)-2-pyrimidinyl]amino] phenyl] benzamide (Purity by HPLC: 99.6%).

With the rapid development of chemical substances, we look forward to future research findings about 152460-10-1.

Reference:
Patent; ACTAVIS GROUP PTC EHF; KHUNT, Mayur, Devjibhai; PATIL, Nilesh, Sudhir; PAGIRE, Haushabhau, Shivaji; PRADHAN, Nitin, Sharadchandra; WO2011/95835; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem