Tag: M.W:200-300

Application of 851386-35-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 851386-35-1, name is 2,3-Difluoro-5-iodopyridine. This compound has unique chemical properties. The synthetic route is as follows.

Step 1: 1-(3-Fluoro-5-iodo-pyridin-2-ylamino)-2-methyl-propan-2-ol 2,3-Difluoro-5-iodopyridine (500 mg, 2.07 mmol) was dissolved in NMP (500 muL) and pyridine (201 mul, 2.49 mmol, 1.2 equiv.) and 1-amino-2-methylpropan-2-ol (555 mg, 6.22 mmol, 3 equiv.) were added at room temperature. The mixture was stirred for 16 hours at 100° C. The reaction mixture was cooled and extracted with saturated NaHCO3 solution and two times with a small volume of dichloromethane. The crude product was purified by flash chromatography by directly loading the dichloromethane layers onto a silica gel column and eluting with an ethyl acetate:heptane gradient 0:100 to 100:0. The desired 1-(3-fluoro-5-iodopyridin-2-ylamino)-2-methylpropan-2-ol (590 mg, 1.9 mmol, 91.7percent yield) was obtained as a colorless oil, MS: m/e=311.0 (M+H+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 851386-35-1, 2,3-Difluoro-5-iodopyridine.

Reference:
Patent; Green, Luke; Guba, Wolfgang; Jaeschke, Georg; Jolidon, Synese; Lindemann, Lothar; Ricci, Antonio; Rueher, Daniel; Stadler, Heinz; Vieira, Eric; US2011/251169; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 65-22-5, name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C8H10ClNO3

General procedure: In a round bottom flask, pyridoxal hydrochloride (0.201g; 1.0mmol) was added to methanol (15mL) and the resulting suspension was subjected to magnetic stirring at room temperature until complete dissolution of the pyridoxal molecule. Then, the corresponding aniline (0.120g of 2-fluoroaniline; 0.130g of 2-chloroaniline, 0.170g of 2-bromoaniline or 0.220g of 2-iodoaniline; 1.0mmol for each) dissolved in methanol (5 mL) was added. The resulting mixture was kept under magnetic stirring at reflux temperature for 2.0h. After this period, the flask contents were cooled to room temperature and the solvent evaporated. The resulting solid was washed with small portions of ice water and diethyl ether and dried in a desiccator with CaCl2. For the synthesis of the ligand containing aniline, the same conditions were used, but without potassium hydroxide (0.093g of aniline was added to 15mL of methanol and 1mmol of pyridoxal hydrochloride; 0.201g). Properties – orange crystals, yield 85%. Melting point: 207C. Anal.Calc. for [C14H13BrN2O2] C, 47.02; H, 3.95; N, 7.83. Found: C, 46.93; H, 3.90; N, 7.79%. IR (KBr pellets, cm-1): 3209 [w, nu(O-H)]; 1627 [m, nu(C=N)]; 1387 [m, nu(C-N)], 1257 [s, nu(C-O)phenol], 1033 [s, nu(C-O)alcohols], 694 [m, nu(C-Br)alcohols] and 620 [s, nu(O-H)alcohols] (w=weak; m=medium; s=strong). 1H NMR (ppm, DMSO-d6): delta 2.46 (s, 3H, CH3); 4.80 (s, 2H, CH2); 7.32-7.81 (m, 4H, Ar); 8.03 (s, 1H, Py) and 9.21 (s, 1H, CHimine)

With the rapid development of chemical substances, we look forward to future research findings about 65-22-5.

Reference:
Article; Pereira, Mateus Brum; Fontana, Liniquer Andre; Siqueira, Josieli Demetrio; Auras, Bruna L.; da Silva, Marcos P.; Neves, Ademir; Gabriel, Philipe; Terenzi, Hernan; Iglesias, Bernardo Almeida; Back, Davi Fernando; Inorganica Chimica Acta; vol. 469; (2018); p. 561 – 575;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1604-14-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1604-14-4, name is 2,6-Dichloro-isonicotinic acid ethyl ester, molecular formula is C8H7Cl2NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step A: 2,6-Dichloro-isonicotinic acid ethyl ester (45 mmol), Cs2CO3 (1.1 eq.) and Phenol (1 eq.) is dissolved in DMF (100 ml). The reaction suspension is heated to 150 0C for 10 minutes in the microwave. After filtration, the solvent is removed in vacuo. 2-Chloro-6-phenoxy-isonicotinic acid ethyl ester is obtained after column chromatography (Heptan / ethyl acetate) as a colorless oil in a yield of 57 %. HPLC (Method A): 3.59 min, LCMS (Method A): 2.81 min, 287.2 m/z (MH+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1604-14-4, 2,6-Dichloro-isonicotinic acid ethyl ester.

Reference:
Patent; MERCK PATENT GmbH; WO2009/106209; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1210419-26-3, name is Methyl 6-bromo-5-fluoropicolinate. This compound has unique chemical properties. The synthetic route is as follows. Safety of Methyl 6-bromo-5-fluoropicolinate

In a sealed tube to a mixture of methyl 6-bromo-5-fluoropyridine-2-carboxylate (374 mg, 1.60 mmol) and (2,6-difluoro-3-methoxyphenyl)boronic acid (150 mg, 0.798 mmol) in THF (6.0 mL) and water (0.6 mL) was added potassium fluoride (153 mg, 2.64 mmol). The reaction mixture was purged with N2 for 5 min., then tris(dibenzylideneacetone)dipalladium (0) (180 mg, 0.20 mmol) and tri-tert-butylphosphine (81 mg, 0.40 mmol) were added subsequently. The reaction mixture was then heated at 100 C. for 30 min. After filtration and concentration of the solution under reduced pressure, the residue was purified by silica gel column chromatography using CombiFlash (0 to 40% EtOAc in hexanes) to give the sub-title compound as a white powder (83.3 mg, 35%). LCMS calc. for C14H11F3NO3 (M+H)+: m/z=298.1. Found: 298.2.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1210419-26-3, Methyl 6-bromo-5-fluoropicolinate.

Reference:
Patent; INCYTE CORPORATION; Xue, Chu-Biao; Li, Yun-Long; Geng, Hao; Pan, Jun; Wang, Anlai; Zhang, Ke; Yao, Wenqing; Zhang, Fenglei; Zhuo, Jincong; US2014/200227; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6295-87-0, name is 1-Aminopyridinium Iodide. This compound has unique chemical properties. The synthetic route is as follows. Formula: C5H7IN2

General procedure: Potassium carbonate (9.0 mmol) for 3a-t or triethylamine (9.0 mmol) for 3u was added to a solution of 1-aminopyridinium iodide 1 (3.0 mmol) in acetonitrile (25 mL) for 3a-t or EtOH (25 mL) for 3u. The reaction mixtures were stirred vigorously for 10-20 min at room temperature to give a dark purple solution, to which electrophiles 2a-u (3.0 mmol) were added in one portion. The mixtures were stirred at rt for 3-24 h except for 3e, which was heated under reflux for 5h. Mixtures 3a-t were filtered to remove inorganic salts, which were washed with acetonitrile 3-5 times. The combined filtrates were concentrated in vacuo and the residues were purified either by gradient elution chromatography over silica gel and/or by recrystallization.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6295-87-0, 1-Aminopyridinium Iodide.

Reference:
Article; Zhang, Hong; Wang, Zuoquan; Jabeen, Farukh; Gopinathan-Pillai, Girinath; Zhou, Wenfeng; Steel, Peter J.; Hall, C. Dennis; Katritzky, Alan R.; Tetrahedron Letters; vol. 57; 1; (2016); p. 20 – 24;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 153034-90-3, name is 2-Chloro-4-iodonicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C6H3ClINO

The following compounds were dissolved in a mixed solution of 200 ml of toluene, 100 ml of ethanol, and 100 ml of a 2-normal aqueous sodium carbonate solution.Compound 1-1: 3.83 g (14.3 mmol)Compound 4-4: 4.0 g (12.9 mmol)While the resulting reaction solution was stirred at a room temperature in a nitrogen atmosphere, 0.83 g (0.72 mmol) of tetrakis(triphenylphosphine)palladium(0) was added in the reacting solution. The reaction solution was heated to 60 degrees Celsius and then stuffed for 7 hours. After the reaction was completed, water was added to the reaction solution. The organic layer was extracted with toluene and dried with anhydrous sodium sulfate. Subsequently, the solvent was distilled off under reduced pressure. The residue was purified by column chromatography (gel used in chromatography: BW300 (produced by Fuji Silysia Chemical Ltd.), developing solvent:ethyl acetate/heptane = 1/2) and washed with methanol. Thus, 1.6 g (yield 38%) of Compound 4-5 was prepared.

With the rapid development of chemical substances, we look forward to future research findings about 153034-90-3.

Reference:
Patent; CANON KABUSHIKI KAISHA; ABE, Shigemoto; KAMATANI, Jun; KISHINO, Kengo; SAITOH, Akihito; YAMADA, Naoki; KOSUGE, Tetsuya; HORIUCHI, Takayuki; NISHIDE, Yosuke; MIYASHITA, Hirokazu; WO2014/115528; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 152460-10-1, name is N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine. This compound has unique chemical properties. The synthetic route is as follows. name: N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine

Embodiment 2 In a 5000 ml dried 4-neck flask, 3000 ml dichloromethane,277 g 4-methyl-N-3-(4-pyridin-3-yl-pyrimidin-2-yl)-1,3-benzenediamine, and 270 g 4-(4-methyl-piperazin-1-methyl)-benzoic acid ethyl ester were added. After it was stirred to dissolve, 100 g sodium methoxide was then added. The mixture was heated to 40 C. for reflux and reaction overnight until the reaction was detected to be complete, and then was concentrated to remove toluene. The residue solid was washed with water and dried, thus 455 g Imatinib was obtained, and the yield was 92.0%. The data of spectrum is the same as above.

With the rapid development of chemical substances, we look forward to future research findings about 152460-10-1.

Reference:
Patent; Shen, Xin; He, Xiao; Yang, Jidong; Wu, Shaohong; Zhan, Huaxing; US2013/41149; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 117007-52-0 , The common heterocyclic compound, 117007-52-0, name is 3-Iodo-1H-pyrazolo[3,4-b]pyridine, molecular formula is C6H4IN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound (M-2) was dissolved in THF (8.4 mL)TEA (234 muL, 1.68 mmol),(Boc) 2 O (289 muL, 1.26 mmol) and DMAP(10.3 mg, 0.0839 mmol) were sequentially added,And the mixture was stirred at room temperature for 1 hour.Water was added to the reaction solution, and the mixture was extracted with ethyl acetate.The organic layer was washed with water,And then washed successively with saturated brine,After drying with anhydrous sodium sulfate, filtration was carried out.After distilling off the solvent under reduced pressure,The residue was purified by silica gel column chromatography (n-hexane: ethyl acetate)Compound (VII-10)(Yield 151 mg, Yield 52%)As a white solid.

The synthetic route of 117007-52-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kaken Pharmaceutical Co., Ltd.; Watanabe, Atsushi; Sato, Yuki; ogura, Keiji Tamada; Tatsumi, Yoshiyuki; (283 pag.)JP2018/145180; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1001413-01-9, 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 1001413-01-9, blongs to pyridine-derivatives compound. SDS of cas: 1001413-01-9

Compound 53.3 (0.094 grams, 0.204 mmol) was dissolved in methanol (5 ml). A scoop of palladium on carbon (Degussa Type ElOl NEAV wet) was added followed by 4.0M HCl p-Dioxane (1 ml). This mixture was placed on a Parr shaker at 40 psi for 48 hours, filtered through Celite, and concentrated. This residue was mixed with Compound 20.2 (54 milligrams, 0.204 mmol), N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (47 milligrams, 0.245 mmol) and 1-hydroxybenzotriazole monohydrate (38 milligrams, 0.245 mmol), dissolved in N,N-dimethylformamide (2 ml) and diisopropylethylamine (0.178 ml, 1.02 mmol) was added. The reaction was stirred at ambient temperature for 16 hours and then flooded with ethyl acetate, washed with saturated sodium bicarbonate, brine, dried over sodium sulfate, filtered and concentrated to yield Compound 53.4 (2.8 milligrams, 0.006 mmol). ES (+) MS m/e = 461 (M+H). IH NMR (400 MHz, MeOH-d4) delta ppm 4.60 (s, 2 H) 5.14 (s, 2 H) 6.49 (m, 1 H) 6.60 (m, 1 H) 7.11 (m, 2 H) 7.23 (m, 1 H) 7.37 (m, 1 H) 7.83 (m, 1 H) 7.96 (m, 1 H) 8.29 (m, 1 H) 8.40 (m, 1 H) 8.69 (d, J=8.31 Hz, 1 H).

The synthetic route of 1001413-01-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUNESIS PHARMACEUTICALS; BIOGEN IDEC, INC.; WO2008/5457; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1214377-42-0, name is 5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below., Product Details of 1214377-42-0

Alternative synthesis for intermediate 24:To a glass flask was added (S)-3-(5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino)- pyrrolidine-1-carboxylic acid tert-butyl ester (intermediate 23) (6.331 g, 15.86 mmol), 5- bromo-2-methoxy-3-(trifluoromethyl)pyridine (intermediate 1 ) (4.465 g, 17.442 mmol), sodium tert-butoxide (2.29 g, 23.78 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.726 g, 0.793 mmol), di-tert-butyl(2′-methylbiphenyl-2-yl)phosphine (0.297 g, 0.951 mmol) and anhydrous ferf-butanol (30 mL). The flask was flushed with a stream of nitrogen for 15 sec and capped. The mixture was heated with stirring for 4h under reflux. The mixture was allowed to cool to rt and partitioned between EtOAc (100 mL) and water (20 mL). The biphasic mixture was filtered the through a celite pad. The organic layer was separated and concentrated in vacuo to give crude (S)-3-[6-(6-methoxy-5-trifluoromethyl-pyridin-3-yl)- 5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ylamino]-pyrrolidine-1 -carboxylic acid tert-butyl ester as a yellow foam (7.46 g, 95% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1214377-42-0, 5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine.

Reference:
Patent; NOVARTIS AG; FERNANDES GOMES DOS SANTOS, Paulo Antonio; HOeGENAUER, Klemens; HOLLINGWORTH, Gregory; SOLDERMANN, Nicolas; STOWASSER, Frank; TUFILLI, Nicola; ZECRI, Frederic; WO2013/1445; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem