Tag: M.W:200-300

Application of 61338-13-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 61338-13-4, name is 2-(4-Methyl-2-phenylpiperazin-1-yl)nicotinic acid, molecular formula is C17H19N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a 1000 ml three-necked flask, 600 ml of tetrahydrofuran, 2- (4-methyl-2-phenyl-1-piperazinyl)(134 g, 0.45 mol),Zinc chloride (306 g, 2.25 mol) was added sodium borohydride (85 g, 2.25 mol) in portions carefully. The temperature was raised to 60-85 C after addition and reflux with stirring for 16 hours, cooled to 0 C and carefully quenched with methanol The reaction mixture was removed under reduced pressure. 600 ml of 6N hydrochloric acid was added and the mixture was heated to 80 C with heating and stirred for 1 hour. The mixture was cooled to room temperature and extracted with methylene chloride (2 L × 3). The organic phase was dried over 1 kg of anhydrous sodium sulfate, A white solid was obtained. The white solid was further dried by blowing with air at 50 C to give 113 g of 1-(3-hydroxymethylpyridin-2-yl) -4-methyl-2-phenylpiperazine as a white solid in 89% yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 61338-13-4, 2-(4-Methyl-2-phenylpiperazin-1-yl)nicotinic acid.

Reference:
Patent; Beijing Ha Sanlian Science And Technology Co., Ltd.; Harbin Sanlian Pharmaceutical Co., Ltd.; Liu Jinai; Li Yuanzhen; Ning Ruibo; Wang Mingxin; (8 pag.)CN105367571; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1060805-69-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1060805-69-7, name is 1-(4-Bromopyridin-2-yl)ethanone. A new synthetic method of this compound is introduced below.

Methyl 2-bromo benzoate (methyl-2-bromobenzoate) (1 eq.)Was dissolved in 180 mL THF, into the NaH (2 eq.) Was stirred for 30 minutes. After stirring, 1 – (4-bromo-2-yl) ethane-1-one (1- (4-bromopyridin-2-yl) ethan-1-one) was dropwise added (1 eq.) Slowly. Stirred for 2 hours at room temperature and heated at 100 16 hours. When the reaction is complete and then lower the temperature to room temperature, then extracted using ethyl acetate (ethyl acetate) and 1N HCl, aqueous NaHCO3, H2O. Purification separated by column chromatography to give a 12-1 after extraction.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1060805-69-7, 1-(4-Bromopyridin-2-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Patent; Hee Sung Material Co., Ltd; Lee, Hyun Ju; Kim, Gi Yeong; Lee, Do Hyung; Choe, Jin Sok; Uhm, Song Jin; Lee, Ju Dong; (46 pag.)KR2016/1537; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39856-50-3, name is 5-Bromo-2-nitropyridine, the common compound, a new synthetic route is introduced below. Product Details of 39856-50-3

Method- 1Piperazine (85 g) and 5-Bromo-2-nitropyridine (100 g) were added in DMF and cooled to 50-60C, followed by addition of 2-propanol (1000 ml) and stirred for 1 hr. The reaction mixture was further cooled to 20-30C and stirred for 2-3 hrs. The reaction mass was filtered under vacuum and washed with 2-propanol. The resulting solid was treated with Boc anhydride (161 g) in the presence of diisopropyl ethyl amine (95 g) in dichloromethane (500 ml) at ambient temperature. Product was isolated by addition of n-heptane (1200 mL) followed by filtration and washing with n-heptane and dried under vacuum at 50-60C to give pale yellow solid (130 g).Yield: 85.0 %; HPLC Purity: 99.0%

The synthetic route of 39856-50-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FRESENIUS KABI ONCOLOGY LTD.; SOKHI, Sarbjot Singh; SINGH, Govind; LAHIRI, Saswata; PANDEY, Maneesh Kumar; TIWARI, Raj Narayan; SHUKLA, Sonu; MUSMADE, Sachin; DUA, Heena; CABRI, Walter; (70 pag.)WO2019/82143; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 14529-54-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14529-54-5, name is 3,5-Dibromo-1-methylpyridin-2(1H)-one, molecular formula is C6H5Br2NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 335a 5-Bromo-3-(6,6-dimethyl-6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazin-2-ylamino)-1-methylpyridin-2(1H)-one 335a A 100-mL round-bottomed flask equipped with a reflux condenser was charged with 1,4-dioxane (10 mL), 6,6-dimethyl-6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazin-2-amine 330g (167 mg, 1.0 mmol), 3,5-dibromo-1-methylpyridin-2(1H)-one (320 mg, 1.2 mmol), Pd2(dba)3 (91 mg, 0.10 mmol), XantPhos (116 mg, 0.20 mmol), and cesium carbonate (652 mg, 2.0 mmol). After three cycles of vacuum/argon flush, the mixture was heated at 100 C for 3 h. It was then filtered and the filtrate was evaporated under reduced pressure. The residue was purified by silica-gel column chromatography eluting with 100:1 dichloromethane/methanol to afford 335a (210 mg, 60%) as a yellow solid. MS-ESI: [M+H]+ 352.9

According to the analysis of related databases, 14529-54-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F.Hoffmann-La Roche AG; CRAWFORD, James John; ORTWINE, Daniel Fred; WEI, BinQing; YOUNG, Wendy B.; EP2773638; (2015); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 848498-98-6, name is 2,6-Dichloro-N-methoxy-N-methylisonicotinamide, the common compound, a new synthetic route is introduced below. Product Details of 848498-98-6

A mixture of 88-1 (20.0 g, 85.1 mmol), boronic acid (13.1 g, 93.6 mmol), Pd(dppf)Cl2 (3.1 g, 4.25 mmol) and TBAF (1 M, 127.6 mL) in DCM (400 mL) was stirred at 25 C. for 12 h under N2. The solution was concentrated, and the residue was diluted with H2O (1 L) and extracted with EA (800 mL). The organic phase was washed with brine, dried with anhydrous Na2SO4, filtered and concentrated. The residue was purified by column chromatography using 520% EA in PE as eluent to give 88-2 (17.2 g, 68.6%) as a yellow oil. MS: m/z 295.7 [M+H]+.

The synthetic route of 848498-98-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Alios BioPharma, Inc.; Wang, Guangyi; Beigelman, Leonid; Truong, Anh; Stein, Karin Ann; (234 pag.)US2016/244460; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 845827-14-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 845827-14-7, name is 2-Bromo-5-(difluoromethoxy)pyridine. A new synthetic method of this compound is introduced below.

Production Example 23 4-[5-(Difluoromethoxy)-2-pyridyl]benzenecarboxylic acid Operations similar to those of Production Example 14 were conducted using 4-carboxyphenylboronic acid and 2-bromo-5-(difluoromethoxy)pyridine, to provide the title compound as white solid. ESI-MS Found:m/z 266[M+H]+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,845827-14-7, 2-Bromo-5-(difluoromethoxy)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1657242; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 113975-22-7, 2-Fluoro-3-iodopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H3FIN, blongs to pyridine-derivatives compound. HPLC of Formula: C5H3FIN

General procedure: 1-(Indol-3-yl)-N-Boc-THIQ 4a (100 mg, 0.287 mmol, 1.0 equiv.), iron(III)-chloride (4.7 mg, 28.7 mumol, 0.1 equiv.), and K3PO4 (122 mg, 0.574 mmol, 2.0 equiv.) were placed in a 2 mL glass vial, and aryliodide (0.431 mmol, 1.5 equiv.) and DMEDA (5.6 muL, 57.4 mumol, 0.20 equiv.) were added followed by dry toluene (300 muL). The reaction mixture was purged with argon for 30 seconds, the vial sealed and heated to 135 C and stirred at this temperature for 24 hours. The black slurry was cooled down to rt, diluted with DCM and filtered through a plug of celite. The solvent of the filtrate was evaporated and the crude product directly subjected to column chromatography using gradient elution with PE_EtOAc=100:0 0:40 (50 minutes) to afford the desired products 7a-e,g.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,113975-22-7, 2-Fluoro-3-iodopyridine, and friends who are interested can also refer to it.

Reference:
Article; Ghobrial, Michael; Mihovilovic, Marko D.; Schnuerch, Michael; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 2186 – 2199;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1211534-25-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1211534-25-6, name is 4-Bromo-5-chloro-2-methoxypyridine, molecular formula is C6H5BrClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[00257j 27F. 4-((3 ,4-cis)-4-((tert-Butyldimethylsilyl)oxy)-3 -methylpiperidin- l-yl)-5 – chloro-2-methoxypyridine: A mixture of 27B (9.70 g, 43.6 mmol), 27E (10.0 g, 43.6mmol), and K2C03 (12.0 g, 87.0 mmol) in DMSO (14.5 mL) was vigorously stirred at110 C overnight. The reaction mixture was diluted with water and extracted with EtOAc. The organic layer was washed with water and brine, dried (MgSO4), and concentrated. Purification via silica chromatography gave 27F as an oil (14.3 g, 77% yield). LC-MS Anal. Calc?d for C18H31C1N2O2Si: 370.18, found [M+H] 371.2.

According to the analysis of related databases, 1211534-25-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ELLSWORTH, Bruce, A.; JURICA, Elizabeth, A.; SHI, Jun; EWING, William, R.; YE, Xiang-Yang; WU, Ximao; ZHU, Yeheng; SUN, Chongqing; WO2014/78609; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 66572-56-3, name is 2-Bromoisonicotinic acid, molecular formula is C6H4BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 66572-56-3

To a solution of 2-bromoisonicotinic acid (1.87 g, 9.26 mmol), 1H-imidazole (573mg, 8.42 mmol) and Cs2C03 (6.03 g, 18.5 mmol) in DMSO (18.6 mL), was added Cui (176mg, 0.926 mmol). The mixture was heated to 125C, stirred for 18 hours, cooled to room10 temperature, filtered and purified by preparative HPLC (1 0-90% acetonitrile in water) to givethe title compound as a light pink solid (1. 72 g, 98% ). MS 190 (MH+).

With the rapid development of chemical substances, we look forward to future research findings about 66572-56-3.

Reference:
Patent; SENOMYX, INC.; TACHDJIAN, Catherine; KARANEWSKY, Donald; WERNER, Sara; DARMOHUSODO, Vincent; YAMAMOTO, Jeff; WO2014/25706; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 885588-12-5, 2-Bromo-5-fluoro-4-pyridinecarboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 885588-12-5, blongs to pyridine-derivatives compound. Application In Synthesis of 2-Bromo-5-fluoro-4-pyridinecarboxylic acid

To a cooled solution of 2-bromo-5-fluoroisonicotinic acid (3.0 g, 13.6 mmol) in benzene (20 ml) and methanol (10 ml) is dropwise over a period of 15 min added under stirring and cooling (trimethylsiliyl)diazomethane (2 M in ether, 14 ml, 28 mmol). The yellow solution is stirred for 1.5 h without cooling and evaporated to dryness. Purification of the residue (3.3 g) bychromatography on a 50 g Silicycle silica cartridge using a heptane / ethyl acetate 10-50% gradient affords methyl 2-bromo-5-fluoroisonicotinate (2.82 g, 88.4%) as a light yellow solid, mp.: 43 – 6C. MS: m/z= 233.9 (M+H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,885588-12-5, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; FLOHR, Alexander; GOBBI, Luca; GROEBKE ZBINDEN, Katrin; KOERNER, Matthias; PETERS, Jens-Uwe; WO2012/76430; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem