Tag: M.W:200-300

Adding a certain compound to certain chemical reactions, such as: 65001-21-0, 5-Bromopyridine-3-sulfonyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 5-Bromopyridine-3-sulfonyl chloride, blongs to pyridine-derivatives compound. Safety of 5-Bromopyridine-3-sulfonyl chloride

To a solution of triethylamine (0.5 mL, 4 mmol) in dichloromethane (5 mL) was added 2.0 M dimethylamine in tetrahydrofuran (0.58 mL, 1.2 mmol). The resultant solution was cooled to 0 C. and 5-bromopyridine-3-sulfonyl chloride [Combi-Blocks, ST-7824] (200 mg, 0.8 mmol) in dichloromethane (1mL) was added dropwise. After stirring at 0 C. to room temperature over 1 h, the reaction mixture was concentrated via rotovap. The residue was purified by FCC to afford the title compound (0.12 g, 60%) LCMS for C7H10BrN2O2S (M+H)+: calculated m/z=265.0, 267.0; found 264.9, 266.9.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,65001-21-0, 5-Bromopyridine-3-sulfonyl chloride, and friends who are interested can also refer to it.

Reference:
Patent; Incyte Corporation; Zou, Ge; Combs, Andrew P.; Buesking, Andrew W.; (62 pag.)US2016/229843; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 910543-72-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 910543-72-5, name is 3-Amino-5-bromo-1-methylpyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 3-amino-5-bromo-1 -methyl-1 ,2-dihydropyridin-2-one (406.08 mg, 2.000 mmol, 1 equiv) and Et3N (1 619.05 mg, 16.000 mmol, 8 equiv) in DCM (5 ml_) was added acetyl chloride (628.00 mg, 8.00 mmol, 4 equiv) dropwise at 0 degrees C. The mixture was stirred for 1 hour at room temperature. Then the solvent was evaporated, and the residue was purified by flash chromatography, eluted with EtOAc/PE (0-100%) to give the A/-(5-bromo-1 -methyl-2-oxo-1 ,2-dihydropyridin-3-yl)acetamide (487 mg, 99.36%). LCMS (ESI) m/z: [M+H]+ = 245.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 910543-72-5, 3-Amino-5-bromo-1-methylpyridin-2(1H)-one.

Reference:
Patent; FOGHORN THERAPEUTICS INC.; ZHOU, Qianhe; BOCKER, Michael; MILLAN, David, Simon; CHAN, Ho, Man; SOARES, Luis; NETHERTON, Matthew, Russell; RUPPEL, Sabine, K.; YANG, Zhaoxia; LOWE, Jason, T.; BRUCELLE, Francois; (220 pag.)WO2019/152440; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 148760-75-2, tert-Butyl 1H-pyrrolo[3,2-c]pyridine-1-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 148760-75-2, blongs to pyridine-derivatives compound. Safety of tert-Butyl 1H-pyrrolo[3,2-c]pyridine-1-carboxylate

tert-butyl pyrrolo[3,2-c]pyridine- 1 -carboxylate (P62) (100 mg, 0.46 mmol) was dissolved in ethanol (8 ml) and acetic acid (8 ml) and passed through the H-Cube (0.5 mI/mm, controlled H2, Rh/C cartridge, 60 C, 60 Bar), recycling reaction mixture for 3 % hours. The solution was concentrated under reduced pressure and the product purified by SCX (500 mg) to afford teit-butyl (3aS, 7aR)-2, 3, 3a,4, 5,6,7, 7a-octahydropyrrolo[3,2- c]pyridine- 1 -carboxylate (P64) (50 mg).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,148760-75-2, its application will become more common.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; PUGLIESE, Angelo; FRANCIS, Stuart; MCARTHUR, Duncan; SIME, Mairi; BOWER, Justin; BELSHAW, Simone; (315 pag.)WO2019/34890; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1009735-24-3, name is Methyl 6-bromo-2-methoxynicotinate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: Methyl 6-bromo-2-methoxynicotinate

Step 3: 6-bromo-2-methoxy-nicotinamjde; beta-bromo^-methoxy-nicotinic acid methyl ester (0.45g, 183mmol) and ammonium hydroxide (5 mL) were combined in a sealed tube and heated to 700C for 3 h. The reaction was cooled to room temperature, filtered and rinsed with water to obtain the title compound as a white solid (0.278 g, 66%). 1 H NMR (500 MHz, DMSO-d6) delta ppm 3.96 (3 H, s), 7.35 (1 H, d, J=7.8 Hz), 7.68 (1 H, br. s.), 7.76 (1 H, br. s.), 8.04 (1 H, d, J=7.8 Hz).

With the rapid development of chemical substances, we look forward to future research findings about 1009735-24-3.

Reference:
Patent; PFIZER INC.; ARHANCET, Graciela Barbieri; CASIMIRO-GARCIA, Agustin; CHEN, Xiangyang; HEPWORTH, David; MEYERS, Marvin Jay; PIOTROWSKI, David Walter; RAHEJA, Raj Kumar; WO2010/116282; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 62774-90-7, 2,6-Dichloro-4-methylnicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 62774-90-7, blongs to pyridine-derivatives compound. Product Details of 62774-90-7

2,6-Dichloro-4-methyl-nicotinic acid (0.234 g, 1.14 mmol) and hydrogen peroxide- urea adduct (0.537 g, 5.70 mmol) were suspended in CH2Cl2 to give a white slurry. Trifluoroacetic anhydride (0.65 ml, 4.67 mmol) was added dropwise over 5 minutes and the resulting pale yellow solution was stirred overnight at rt. The reaction mixture was quenched with water (10 ml) and then dry loaded onto silica gel and purified using column chromatography (MeCN/MeOH/NH4OH, 8:1:1, v/v/v) to give 2,6-dichloro-4-methyl-nicotinic acid-iV-oxide as a pale yellow crystalline solid (0.103 g, 41 %). 1H NMR (CD3OD ) delta 2.37 (s, 3H), 7.60 (s, IH).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,62774-90-7, 2,6-Dichloro-4-methylnicotinic acid, and friends who are interested can also refer to it.

Reference:
Patent; ANORMED INC.; WO2006/138350; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 17282-40-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.17282-40-5, name is 1-(2-Ethoxy-2-oxoethyl)pyridin-1-ium bromide, molecular formula is C9H12BrNO2, molecular weight is 246.1011, as common compound, the synthetic route is as follows.

General procedure: To a magnetically stirred solution of N- functionalized pyridinium, isoquinolinum, or quinolinium salt 1, 4, or 5 (1 mmol) and triphenylphosphine (1 mmol) in 3 mL DMF was added solution of alkyl propiolate 2 (1 mmol) in 2 mL DMF at -5-0 C temperature. The reaction mixture stirred for 12 h, and then the mixture was poured onto H2O (5 mL), extracted with AcOEt (15 mL), dried (MgSO4), and the solvent was removed under reduced pressure. The residue was separated by silica gel (Merck 230-240 mesh) column chromatography using hexane-ethyl acetate mixture as eluent.

Statistics shows that 17282-40-5 is playing an increasingly important role. we look forward to future research findings about 1-(2-Ethoxy-2-oxoethyl)pyridin-1-ium bromide.

Reference:
Article; Hashemi, Seyed Abolghasem; Khalili, Gholamhossein; Synthetic Communications; vol. 45; 21; (2015); p. 2491 – 2497;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 120277-69-2, Adding some certain compound to certain chemical reactions, such as: 120277-69-2, name is 3-Bromo-5-(chloromethyl)pyridine,molecular formula is C6H5BrClN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 120277-69-2.

[C] (5-Bromo-pyridin-3-yl)-methylamine 3-Bromo-5-chloromethyl-pyridine (10.3 g, 50 mmol) was dissolved in ammonia methanol solution (7 N, 250 ml) and heated at 60 C. overnight. After aq. NaOH (1N) solution was added to adjust the pH to >12, the mixture was extracted with EtOAc. The organic layer was washed with brine, dried over anhy. Na2SO4, filtered and concentrated in vacuo. The crude product was purified by recrystallization to give title compound as a solid (2.5 g, 27%). MS: 187.1 (M+H+).

According to the analysis of related databases, 120277-69-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hoffmann-La Roche Inc.; Aebi, Johannes; Amrein, Kurt; Chen, Wenming; Hornsperger, Benoit; Kuhn, Bernd; Liu, Yongfu; Maerki, Hans P.; Mayweg, Alexander V.; Mohr, Peter; Tan, Xuefei; Wang, Zhanguo; Zhou, Mingwei; US2013/143863; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 75308-46-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 75308-46-2, name is tert-Butyl 2,6-dichloroisonicotinate. A new synthetic method of this compound is introduced below.

To a solution of 2,6-dichloro-isonicotinic acid tert.-butyl ester (3.35 g, 13.5 mmol), Fe(acac)3 (512 mg, 1.45 mmol) and NMP (1.58 g, 16.0 mmol) in THF (400 mL), a solution of methylmagnesium iodide (11.67 g, 70.2 mmol) in THF is slowly added at -77 C. The brown solution turns green-grey. After the addition of about half of the Grignard reagent the dark brown suspension is warmed to it and stirred for 30 min before it is again cooled to -70 C. The other half of the Grignard reagent is added, the mixture turns dark green-brown and is warmed to it and stirred for 16 h. The mixture is cooled to -50 C. and another portion of the Grignard reagent (2.24 g, 13.5 mmol) is added. The reaction mixture is warmed to rt, stirred for 16 h and then carefully quenched with 1 N aq. HCl (100 mL) and diluted with ether. The org. layer is separated and the aq. phase is extracted with ether. The combined org. extracts are dried over MgSO4, filtered and evaporated. The crude product is purified by MPLC on silica gel to give 2,6-dimethylisonicotinic acid tert.-butyl ester (2.37 g) as a pale yellow oil; LC-MS: tR=0.65 min, [M+1]+=208.29.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75308-46-2, its application will become more common.

Reference:
Patent; Actelion Pharmaceuticals Ltd.; US2010/63108; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 885500-55-0, Ethyl 4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of Ethyl 4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylate, blongs to pyridine-derivatives compound. Quality Control of Ethyl 4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

General procedure: 5.1.3 Ethyl 4-(cycloheptylamino)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (5c) A mixture of 4 (112 mg, 0.50 mmol), cycloheptanamine (76 muL, 0.60 mmol), and Et3N (209 muL, 1.5 mmol) in NMP (3.0 mL) was heated in a microwave reactor at 180 C for 1 h. After cooling to room temperature, the reaction mixture was quenched with water, extracted with EtOAc, dried over MgSO4, and evaporated in vacuo. The crude mixture was purified by column chromatography on silica gel (CHCl3/MeOH = 100:0 to 90:10) to give the product (135 mg, 90%). 5.1.4 Ethyl 4-[(cyclohexylmethyl)amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (5d) Compound 5d was prepared in 62% yield as a white solid by a method similar to that described for 5c. 1H NMR (DMSO-d6) delta 1.01-1.33 (m, 5H), 1.31 (t, J = 7.1 Hz, 3H), 1.61-1.86 (m, 6H), 3.52 (t, J = 6.1 Hz, 2H), 4.26 (q, J = 7.1 Hz, 2H), 6.66 (d, J = 3.6 Hz, 1H), 7.15 (d, J = 3.6 Hz, 1H), 8.53 (s, 1H), 8.81 (t, J = 5.4 Hz, 1H), 11.67 (br s, 1H); MS (ESI) m/z 302 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,885500-55-0, Ethyl 4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylate, and friends who are interested can also refer to it.

Reference:
Article; Yamagishi, Hiroaki; Shirakami, Shohei; Nakajima, Yutaka; Tanaka, Akira; Takahashi, Fumie; Hamaguchi, Hisao; Hatanaka, Keiko; Moritomo, Ayako; Inami, Masamichi; Higashi, Yasuyuki; Inoue, Takayuki; Bioorganic and Medicinal Chemistry; vol. 23; 15; (2015); p. 4846 – 4859;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 71701-92-3, name is 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C6H2BrClF3N

A suspension of 3-bromo-2-chloro-5-trifluoromethylpyridine (1.00 g, 3.8 mmol), (cyclopenthylmethyOethylamine (0.63 g, 4.6 mmol), potassium carbonate (1.06 g, 7.7 mmol) in toluene is irradiated in a microwave reactor for 30 min. After adding water, the mixture is extracted with ethyl acetate. The combined organic layer is washed with brine, dried over magnesium sulfate, filtrated and concentrated to give (3-bromo-5-trifluoromethylpyridin-2- yl)(cyclopentylmethyl)ethylamine (1.32 g, 98 %), which is used for the next reaction without further purification.1H-NMR (400MHz, CDCI3), delta (ppm): 1.11-1.20 (m, 2H), 1.18 (t, 3H), 1.45-1.70 (m, 6H), 2.15 -2.22 (m, 1H), 3.42 (d, 2H), 3.52 (q, 2H), 7.90 (d, 1H), 8.37 (d, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 71701-92-3, 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2007/73934; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem