Tag: M.W:200-300

Synthetic Route of 152460-10-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 152460-10-1, name is N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The final target compounds were synthesized from 6-methyl-N-(4-(pyridin-3-yl) pyrimidin-2-yl) benzene-1,3-diamine 8(2 mmol), DMF (10 mL), and DIPEA (4 mmol) followed by substituted aromatic acid (2 mmol) was added and stirred at room temperature for 1 h. After completion of the reaction mixture was poured into ice-cold water. The obtained yellow precipitate washed with water and dried to get target titled product pyrimidine scaffold benzamide derivatives (9 a-k).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 152460-10-1, N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine.

Reference:
Article; Thirumurugan; Lakshmanan, Sivalingam; Govindaraj, Dharman; Daniel Prabu, D. Sam; Ramalakshmi; Arul Antony; Journal of Molecular Structure; vol. 1171; (2018); p. 541 – 550;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 215364-85-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 215364-85-5, name is 3-Bromo-2-chloropyridin-4-amine, molecular formula is C5H4BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A 2 L 3 neck RBF was charged with 3-bromo-2-chloro-4-amino-pyridine (50.0 g, 241 mmol) in concentrated H2SO4 (36 mL) at 0 C. open to air. KNO3 (48.7 g, 482 mmol) was then added. The solution was allowed to first warm to room temperature (rt) for 1 h and then was heated to 90 C. for 3 h. The reaction mixture was cooled to rt and was poured into ice water. The obtained solids were filtered and washed with water. After drying under vacuum overnight 3-bromo-2-chloro-5-nitropyridin-4-amine was obtained as an orange-yellow solid (49 g, 81%). This was used directly without further purification.

According to the analysis of related databases, 215364-85-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Universal Display Corporation; Layek, Suman; Ji, Zhiqiang; Dyatkin, Alexey Borisovich; Boudreault, Pierre-Luc T.; Tsai, Jui-Yi; (251 pag.)US2019/393431; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 893423-62-6 , The common heterocyclic compound, 893423-62-6, name is tert-Butyl (2-chloro-3-formylpyridin-4-yl)carbamate, molecular formula is C11H13ClN2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of tert-butyl (2-chloro-3-formyl-4-pyridinyl)carbamate (1-5) (10 g,39 mmol) and DBU (12 niL, 78 mmol) in THF (130 mL) was added phenylacethyl chloride (5.7 mL, 43 mmol) at 00C. The reaction was allowed to slowly warm to room temperature for overnight. The solvent was removed under reduced pressure, and the residue was diluted with EtOAc, washed with IN HCl, dried (MgSO4), filtered, and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel to give tert-butyl 5-chloro-2- oxo-3-phenyl-l,6-naphthyridine-l(2H)-carbamate (62-1) as a colorless solid.

The synthetic route of 893423-62-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP &; DOHME CORP.; BANYU PHARMACEUTICAL CO., LTD.; ARMSTRONG, Donna, J.; GOTO, Yasuhiro; HASHIHAYATA, Takashi; KATO, Tetsuya; KELLY, Michael, J., III; LAYTON, Mark, E.; LINDSLEY, Craig, W.; OGINO, Yoshio; ONOZAKI, Yu; RODZINAK, Kevin, J.; ROSSI, Michael, A.; SANDERSON, Philip, E.; WANG, Jiabing; YAROSCHAK, Melissa, M.; WO2010/88177; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 63897-12-1 ,Some common heterocyclic compound, 63897-12-1, molecular formula is C6H4Cl2N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

PREPARATION 10; Benzyl-(2-chloro-6-methyl-3-nitro-pyridin-4-yl)-amine; 2,4-Dichloro-6-methyl-3-nitro-pyridine (2 g, 9.7 mmol) and triethylamine (1.35 mL, 9.7 mmol) were dissolved in 40 mL THF and cooled (ice/water) to 5 C. A solution of benzylamine (1.04 g, 9.7 mmol) in 10 mL THF was added dropwise and the mixture was then allowed to warm gradually to room temperature overnight. The mixture was evaporated in vacuo, partitioned between EtOAc (50 mL) and water (20 mL). The organic layer was washed with saturated aqueous NaHCO3 (10 mL), dried (MgSO4) and evaporated in vacuo to an orange gum. This gum was preabsorbed onto silica gel and then purified by column chromatography, eluting with DCM:pentane 3:1. Appropriate fractions combined and evaporated in vacuo to yield the title compound as a yellow solid (716 mg).1H NMR (CDCl3) 2.32 (s, 3H), 4.38 (d, 2H), 6.39 (s, 1H), 6.90 (broad s, 1H), 7.21 (m, 2H), 7.29 (m, 3H). LC-MS (ELSD, ES+) m/z 278 (MH+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63897-12-1, its application will become more common.

Reference:
Patent; PFIZER LIMITED; US2007/197478; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 889676-37-3 ,Some common heterocyclic compound, 889676-37-3, molecular formula is C6H5BrN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-methoxybenzofuran boronic acid (1.2 mmol), 6-bromonicotinamide (1.0 mmol), Pd(PPh3)2Cl2 (0.024 mmol) and NEt3 (317 muL) were mixed in EtOH (10 mL) in a 20 mL microwave vial. The mixture was stirred at 140 C. for 10 min in a microwave reactor. The mixture was filtered, the obtained precipitate was washed with water and EtOAc and dried under vacuum to afford the title compound (85 mg). 1H NMR delta ppm 9.14 (d, 1H) 8.42 (dd, 1H) 7.97-8.25 (m, 2H) 7.63-7.80 (m, 2H) 7.58 (d, 1H) 7.22 (d, 1H) 6.98 (dd, 1H) 3.81 (s, 3H); MS m/z 269 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 889676-37-3, 6-Bromonicotinamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AstraZeneca AB; US2008/221149; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 73870-24-3, 4-(Bromomethyl)pyridine hydrobromide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 73870-24-3, blongs to pyridine-derivatives compound. SDS of cas: 73870-24-3

Will contain compound 16 (150 mg, 0.386 mmol), Potassium carbonate (138 mg, 1.0 mmol), 4-bromomethylpyridine hydrobromide (102 mg, 0.403 mmol) the mixture with DMF (5 mL) was stirred at room temperature overnight.Water (20 mL) was added and extracted with ethyl acetate (20 mL¡Á3).The combined organic phases were washed sequentially with water (15 mL) and brine (15 mL). Dry over anhydrous sodium sulfate. Evaporate the solvent under reduced pressure.The product is purified by column chromatography (200-300 mesh silica gel,Ethyl acetate: dichloromethane = 1:1 to 10:1 elution),2-[4-Methoxy-3-(pyridin-4-ylmethoxy)-phenyl]-5,7-bis(methoxymethoxy)-4H-benzopyran-4-one (17) (144 mg).The yield was 77.8%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,73870-24-3, 4-(Bromomethyl)pyridine hydrobromide, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu Xin Element Pharmaceutical Technology Co., Ltd.; Shi Dongfang; Fu Changjin; Cheng Xi; Gong Weiwei; Gu Jie; Zhang Min; Li Pengfei; Yang Yan; Jin Wenqing; (57 pag.)CN110294732; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 54916-66-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 54916-66-4, name is 5-Bromo-2-methoxynicotinic acid, molecular formula is C7H6BrNO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 5-bromo-2-methoxynicotinic acid (5 g, 22 mmol) in dichloromethane (75 mL) was treated with Oxalyl dichloride (10 ml) by dropwise at 0 C, then the mixture was stirred at R.T. for 4 hours. A mixture of Ice- H3.H20 was poured into the react solution within an ice-bath and stirred at 0 C for more 10 min and filtered, the filter cake was dried to provide 5-bromo-2-methoxynicotinamide (4.7 g, yield: 94.4%). 1HNMR (400MHz, CDCI3) delta 8.45 (d, J= 2.4 Hz, 1H), 8.20 (d, J= 2.4 Hz, 1H), 7.78 (br, 2H), 3.94 (s, 3H). MS (M+H)+: 231 / 233.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 54916-66-4, 5-Bromo-2-methoxynicotinic acid.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MCCOMAS, Casey Cameron; LIVERTON, Nigel J.; HABERMANN, Joerg; KOCH, Uwe; NARJES, Frank; LI, Peng; PENG, Xuanjia; SOLL, Richard; WU, Hao; PALANI, Anandan; HE, Shuwen; DAI, Xing; LIU, Hong; LAI, Zhong; LONDON, Clare; XIAO, Dong; ZORN, Nicolas; NARGUND, Ravi; WO2013/33971; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 175422-04-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 175422-04-5, name is 2,6-Dibromo-4-nitropyridine. A new synthetic method of this compound is introduced below.

The solution of 2,6-dibromo-4-nitropyridine (0.4 g, 1.419 mmol) and 1, 2,3,4- tetrahydroisoquinoline (0.378 g, 2.84 mmol) in dioxane (2 mL) was stirred at 100 C for 14 h. The reaction mixture was concentrated under reduced pressure and the residue so obtained was purified through silica gel column chromatography by using 10-30% ethyl acetate and pet ether as an eluant to afford 91 A (brown solid, 0.75 g, 1.369 mmol, 48.3 % yield). LC-MS Anal.Calc?d for Ci4Hi2BrN302 333.0, found [M+2] 335.0 Tr = 3.76 min (Method N).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,175422-04-5, 2,6-Dibromo-4-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; MARKWALDER, Jay A.; SHAN, Weifang; WILLIAMS, David K.; NARA, Susheel Jethanand; ROY, Saumya; THANGAVEL, Soodamani; CHERUKU, Srinivas; SISTLA, Ramesh Kumar; (230 pag.)WO2020/23355; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5349-17-7, name is 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide

[0332] 7V-(3-Fluorophenyl)-4-(4-pyridinyl)-l,3-thiazol-2-amine (121). Reaction of bromoketone hydrobromide 1 (0.65 g, 2.3 mmol) and 3-fluorophenylthiourea (120) (0.39 g, 2.3 mmol) gave amine 121 (0.45 g, 71%) as a white powder: mp (EtOAc/pet. ether) 229-230 0C; 1H NMR delta 10.59 (br s, 1 H, NH), 8.63 (dd, J = 4.5, 1.6 Hz, 2 H, H-2′, H-6′), 7.35 (dd, J= 4.5, 1.6 Hz, 2 H, H-3′, H-5′), 7.28-7.31 (m, 1 H, H-2″), 7.76 (s, 1 H, H-5), 7.34-7.41 (m, 2 H, H-5″, H-6″), 6.77-6.84 (m, 1 H, H-4″); 13C NMR delta 163.0, 162.4 (d, J= 240 Hz), 150.1 (2), 147.6, 142.4 (d, J = 11 Hz), 140.8, 130.5 (d, J= 10 Hz), 119.8 (2), 112.7 (d, J= 2 Hz), 108.0, 107.5 (d, J= 21 Hz), 103.5 (d, J= 26 Hz). Anal, calcd for Ci4Hi0FN3S: C, 61.98; H, 3.72; N, 15.49. Found: C, 61.91; H, 3.79; N, 15.20%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5349-17-7, 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide.

Reference:
Patent; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; AUCKLAND UNISERVICES LIMITED; WO2009/114552; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 676371-00-9 ,Some common heterocyclic compound, 676371-00-9, molecular formula is C7H6BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 8.00 g (100 mmol) freshly prepared difluoroacetaldehyde in 560 mL DCM was added 5.30 g (25 mmol) 6-bromoimidazo[1 ,2-a]pyridin-8-amine, 26.49 g (125 mmol) sodium triacetoxy borohydride and 28.5 g (18.56 mL, 250 mmol) TFA and the mixture was stirred for 72 h at rt to give, after working up andpurification, 4.0 g (58 ?) of the title compound. UPLC MS: RT = 0.71 min; m/z (ES+) 277.1 [MH+]; required MW = 276.1. 1 H-NMR (300 MHz ,DMSO-d6), delta [ppm]= 3.69 (2H), 6.36 (1 H), 6.54 (1 H), 7.41 (1 H), 7.77 (1 H), 8.10 (1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,676371-00-9, its application will become more common.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; KLAR, Ulrich; WENGNER, Antje; NEUHAUS, Roland; SIEMEISTER, Gerhard; WO2012/136531; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem