Tag: M.W:200-300

Reference of 944401-56-3, Adding some certain compound to certain chemical reactions, such as: 944401-56-3, name is 5-Bromo-4-(trifluoromethyl)pyridin-2-amine,molecular formula is C6H4BrF3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 944401-56-3.

Method 4: N’-(5-bromo-4-(trifluoromethyl)pyridin-2-yl)-N,N-dimethylformimidamide (I9) (0161) (0162) 2-amino-6-(trifluoromethyl)pyridine (25.0 g, 156 mmol, 1.0 eq.) in dimethyl acetal (25.1 mL, 188 mmol, 1.2 eq.) was added and the mixture was heated at 70 C for 6 hours. The solvent was oratory evaporated under reduced pressure and the residue was recrystallized from hexane to yield the desired 29 product I9 as an off-white solid (65% yield). 1H NMR (400 MHz, CDCl3): delta 8.46 (s, 1 H), 8.38 (s, 1 H), 7.18 (s, 1 H), 3.11 (s, 3 H), 3.08 (s, 3 H); 19F{1H} NMR (376 MHz, CDCl3): delta – 65.0 (s, 3 F).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 944401-56-3, 5-Bromo-4-(trifluoromethyl)pyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Universitaet Basel; Bohnacker, Thomas; Rageot, Denise; Sele, Alexander Markus; Beaufils, Florent; Wymann, Matthias; (51 pag.)EP3231799; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4487-59-6, name is 2-Bromo-5-nitropyridine. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H3BrN2O2

Example 84Synthesis of 3-[6-{4-[5-(nitro)pyridin-2-yl]piperazin-l-yl}-5-phenyl-2- (trifluoromethyl)pyrimidin-4-yl]benzenesulfonamide.Step 1;Preparation of l-(5-nitropyridin-2-yl) piperazine. 2-Bromo-5-nitropyridine (0.3g, 1.48mmol) was treated with piperazine (0.64g, 7.89mmol) in tetrahydrofuran (4mL) and the reaction mixture was stirred for 30 minutes. Subsequently the reaction mixture was poured onto ice- cold water (25mL) and extracted with ethyl acetate (25mL). The organic layer was washed with brine and evaporated to furnish the product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4487-59-6, 2-Bromo-5-nitropyridine.

Reference:
Patent; ORCHID RESEARCH LABORATORIES LIMITED; WO2007/83182; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 861673-68-9, 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine, blongs to pyridine-derivatives compound. Recommanded Product: 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine

104a 1-(2-(2-tert-butylphenoxy)pyridin-3-yl)-3-(2, 4-dichlorophenyl) thiourea [00324] A solution of lb (40 mg, 0.17 mmol) and 2,5- dichlorophenylisothiocyanate (37 mg, 0.18 mmol) in dioxane (2 mL) was heated at 60C for 6 h. More 2,5-dichlorophenylisothiocyanate (37 mg, 0.18 mmol) was added and the mixture was heated at 60C for 8 days. The mixture was concentrated and the residue was purified by column chromatography on silica gel using a continuous gradient from 0% to 40% ethyl acetate in hexanes as eluant. Half of the material was carried to the next step without further purification, the other half was purified by preparative HPLC (continuous gradient from 40% B to 100%, B; A = 90: 10: 0.1 H20 : MeOH: TFA; B = 90 : 10: 0.1 MeOH: H2O : TFA) to afford 104a (8 mg, 43%). 1H NMR (400 MHz, CD30D) 8 ppm 1. 38 (m, 9 H), 6.93 (dd, J=7. 83,1. 52 Hz, 1 H), 7.15 (m, 3 H), 7. 31 (dd, J=8. 59, 2.27 Hz, 1 H), 7.44 (dd, J=7. 83,1. 77 Hz, 1 H), 7.52 (d, J=2. 53 Hz, 1 H), 7.68 (d, J=8. 59 Hz, 1 H), 7.90 (dd, J=5. 05,1. 77 Hz, 1 H), 8.35 (dd, J=7. 71,1. 89 Hz, 1 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,861673-68-9, 2-(2-(tert-Butyl)phenoxy)pyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2005/70920; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 93349-99-6, name is Methyl 5-bromo-6-methoxynicotinate. A new synthetic method of this compound is introduced below., Product Details of 93349-99-6

26B: A mixture of 1A (378 mg, 0.915 mmol), bis(pinacolato)diboron (290 mg,1.143 mmol), potassium acetate (269 mg, 2.74 mmol) and PdC12(dppf)-CH2C12 adduct (37.3 mg, 0.046 mmol) in dioxane (4 mL) was heated at 100 C for 60 mm. After cooling to rt, methyl 5-bromo-6-methoxynicotinate (154 mg, 0.625 mmol) and1,1 ?-bis(di-tert-butylphosphino)ferrocenepalladium dichloride (19.39 mg, 0.030 mmol) were added and the mixture degassed by nitrogen sparge for 5 mm. 2M K3P04 (aq) (0.892 mL, 1.785 mmol) was quickly added and the reaction mixture heated at 100 C for 15 mm. The reaction mixture was cooled to rt and volatiles removed in vacuo. The crude residue was loaded onto a 40g ISCO column and purified by flash chromatography,eluting with 0-100% EtOAc in hexanes. Afforded product (301 mg, 0.572 mmol, 96 % yield) as a crystalline beige solid.MS ESI m/z 499.9 (M+H)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 93349-99-6, Methyl 5-bromo-6-methoxynicotinate.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GUO, Junqing; HART, Amy, C.; MACOR, John, E.; MERTZMAN, Michael, E.; PITTS, William, J.; SPERGEL, Steven, H.; WATTERSON, Scott, Hunter; ANDAPPAN MURUGAIAH SUBBAIAH, Murugaiah; CHEN, Jie; DZIERBA, Carolyn, Diane; LUO, Guanglin; SHI, Jianliang; SIT, Sing-Yuen; (428 pag.)WO2018/148626; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 69045-84-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below.

A mixture of 2,3-dichloro-5-(trifluoromethyl)pyridine (10 mL, 72 mmol), hydrazine (10 mL, 0.32 mol), and ethanol (100 mL) was refluxed for 4 h, allowed to cool to rt, and then concentrated. The residue was partitioned between EtOAc (100 mL) and 0.43M NaOH (175 mL). The organic layer was dried, filtered, concentrated, and dried under vacuum to give 3-chloro-2-hydrazinyl-5-(trifluoromethyl)pyridine as an off- white solid. 1H NMR (400 MHz, DMSO-d6): delta 8.53 (s, IH), 8.35 (d, IH), 7.91 (d, IH), 4.43 (s, 2H); LCMS: 212.3 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,69045-84-7, its application will become more common.

Reference:
Patent; KALYPSYS, INC.; WO2009/117421; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 39856-50-3, Adding some certain compound to certain chemical reactions, such as: 39856-50-3, name is 5-Bromo-2-nitropyridine,molecular formula is C5H3BrN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39856-50-3.

Preparation XX Synthesis of 4-r6-amino-pyridin-3-ylVpiperazine-l-carboxylic acid tert-butyl ester Step 1. Synthesis of 4-f6-nitro-pyridin-3-yl)-piperazine-l-carboxyric acid tert-butyl ester; A mixture of 5-bromo-2-nitropyridine (4.93g, 24.30 mmol) and tert-butyl piperazine-1-carboxylate (5.Og, 26.7 mmol) in acetonitrile (60ml) was heated at refluxed for 3 days. The solvent was evaporated and the solid residue purified by flash chromatography on silica eluting with EtO Ac/Petrol (1:3) and recrystallised from EtO Ac/Petrol to afford the title compound as an orange solid (5.Og, 67%) (LCMS: Rt 2.8, [M+H]+ 309).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 39856-50-3, 5-Bromo-2-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; NOVARTIS AG; WO2008/7123; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1268521-33-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1268521-33-0, name is 3-Bromo-2-chloro-5-nitropyridin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

A dried RBF was charged with Na2CO3 (61.7 g, 582 mmol), in water (75 mL) and was stirred until a solution was obtained. THF (750 mL) and EtOH (150 mL) were then added and the solution was sparged with argon during the following additions; 3-bromo-2-chloro-5-nitropyridin-4-amine (49 g, 194 mmol) was charged, and phenylboronic acid (53.5 g, 388 mmol). After 20 min of sparging argon, Pd(PPh3)4 (17.9 g, 15.5 mmol) was charged. The reaction was sealed and was run under argon at 85 C. Once the reaction was deemed complete it was concentrated directly. To the residual was added water, and the mixture extracted with EtOAc. The combined organic fractions were combined, dried with MgSO4 and concentrated. The residual was purified via silica gel column chromatography, eluting with 0-30% EtOAc/Hexane. 2-(4-amino-3-bromo-5-nitropyridin-2-yl)phenol was isolated as a red semi solid (39 g, 65% yield).

According to the analysis of related databases, 1268521-33-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Universal Display Corporation; Layek, Suman; Ji, Zhiqiang; Dyatkin, Alexey Borisovich; Boudreault, Pierre-Luc T.; Tsai, Jui-Yi; (251 pag.)US2019/393431; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 26218-75-7, name is Methyl 6-bromopicolinate. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of Methyl 6-bromopicolinate

Methylmagnesium iodide (3M in Et20, 1.50 ml, 4.48 mmol) was added to a solution of methyl 6-bromopyridine-2- carboxylate (0.430 g, 1.99 mmol) in dry Et20 (1 5 ml) under N2. After 5 min at RT the reaction was quenched with 1 M HCI (10 ml) and extracted with EtOAc (15 ml). The organic extract was washed with sat. NaHC03 solution (1 5 ml) and brine (10 ml), dried (MgS04) and concentrated in vacuo. The desired product was obtained as a yellow oil (0.365 g, 1.69 mmol, 85%). Rf 0.60 (1 :1 Hexane:EtOAc); I R (cm-1 ) 3420, 2975, 2930, 1731 , 1701 , 1 580, 1 553; 1 H NMR (400 MHz, DMSO-d6) 1.42 (6H, s, C(CH2)2), 5.33 (1 H, s, OH), 7.47 (1 H, dd, J = 7.7, 0.9 Hz, H-5), 7.67 (1 H, dd, J = 7.7, 0.9 Hz, H-3), 7.73 (1 H, dd, J = 7.7, 7.7 Hz, H-4); 13C N MR (125 MHz, DMSO-d6) 30.9 (C(CH2)2), 72.6 (C(CH2)2), 1 18.5 (Ar-C), 126.0 (Ar-C), 140.4 (Ar-C), 140.5 (Ar-C), 170.8 (Ar-C).

With the rapid development of chemical substances, we look forward to future research findings about 26218-75-7.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE; REIGAN, Philip; MATHESON, Christopher; (71 pag.)WO2017/75629; (2017); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 875781-15-0, Adding some certain compound to certain chemical reactions, such as: 875781-15-0, name is 5-Bromo-2-fluoronicotinaldehyde,molecular formula is C6H3BrFNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 875781-15-0.

To a stirred solution of 5-bromo-2-fluoronicotinaldehyde (XV) (250 g, 1.23 mol, 1.0 eq) in EtOH (2.50 L) was added hydrazine hydrate (221 g, 4.41 mol, 3.6 eq) at 25C. The reaction was then heated to 75~80C and stirred for 12 h. The solvent was removed under reduced pressure at 45C. The residual crude solid was triturated in water (750 mL) and EtOH (250 mL). The resultant suspension was filtered and washed with ethanol to give 5 -bromo- lH-pyrazolo[3,4- b]pyridine (XVI) (135 g, 0.68 mol, 55.4% yield) as yellowish solid which was used directly for the next step without further purification. ESIMS found for CeLLtBrNs mlz 199.1 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 875781-15-0, 5-Bromo-2-fluoronicotinaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SAMUMED, LLC.; KC, Sunil Kumar; WALLACE, David Mark; CAO, Jianguo; CHIRUTA, Chandramouli; HOOD, John; (252 pag.)WO2017/23987; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.929000-66-8, name is 3-Bromo-6-chloropyridine-2-carboxylic acid, molecular formula is C6H3BrClNO2, molecular weight is 236.4505, as common compound, the synthetic route is as follows.Recommanded Product: 3-Bromo-6-chloropyridine-2-carboxylic acid

To a stirred suspension of 3-bromo-6-chloropyridine-2-carboxylic acid (3.6 g, 15. mmol) in 1 ,4-dioxane (35 mL) was added (1 R,2R)-N,N-dimethylcyclohexane-1 ,2- diamine (220 mg, 1 .5 mol), Cs2C03 (10 g, 31 mmol), 1 H-1 ,2,3-triazole (2.1 g, 31 mmol), water (0.3 mL) and the mixture was degassed under nitrogen for 10 mins. Cul (295 mg, 1.6 mmol) was added and the mixture was heated at 100C for 6 hrs. The reaction mixture was then allowed to cool to ambient temperature, and concentrated in vacuo. MeOH (20 mL) was added to the residue and the mixture was acidified to pH 2 with 6N hydrochloric acid (approx 6 mL) and concentrated in vacuo. MeOH (20 mL) was added to the residue and concentrated in vacuo (x2). The residue was dissolved in MeOH (15 mL) and DCM (35 mL) and cooled to 0C. TMS diazomethane (39 mL, 77 mmol) was added dropwise (over 15 mins) and the reaction mixture was stirred at ambient temperature for 18 hrs. The reaction mixture was concentrated in vacuo. The crude product was purified by chromatography on the Biotage Isolera Four (100 g column, 10 to 80% EtOAc in heptane) to afford the title compound as an oil (1 .8 g). LCMS (Method G): 1 .03 min, 239 [M+H]+

At the same time, in my other blogs, there are other synthetic methods of this type of compound,929000-66-8, 3-Bromo-6-chloropyridine-2-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; C4X DISCOVERY LIMITED; BLANEY, Emma Louise; MARTIN, Barrie Phillip; NOWAK, Thorsten; WATSON, Martin John; (212 pag.)WO2016/34882; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem