Tag: M.W:200-300

Synthetic Route of 99368-67-9, Adding some certain compound to certain chemical reactions, such as: 99368-67-9, name is 2-Chloro-5-nitro-3-(trifluoromethyl)pyridine,molecular formula is C6H2ClF3N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 99368-67-9.

5. 6-Chloro-5-trifluorom.eihyl-pyridin-3-ylam.ine Heat a mixture of 2-chloro-5-nitro-3-trifluoromethyl-pyridine (2.27 g, 10 mmol), calcium chloride (1.1 g, 10 mmol) and iron powder (4.5 g) in ethanol (30 mL) and water (5 mL) at reflux for 1 hour. Cool the mixture and filter through Celite. Evaporate the filtrate, dissolve the residue in EtOAc (200 mL) and wash with saturated NaHCO3(aq) (100 mL) and brine (100 mL). Dry the organic extract over MgSO4 and remove the solvent under reduced pressure to yield the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 99368-67-9, 2-Chloro-5-nitro-3-(trifluoromethyl)pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NEUROGEN CORPORATION; WO2006/42289; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 183208-22-2, 5-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 183208-22-2, blongs to pyridine-derivatives compound. SDS of cas: 183208-22-2

[0654] To a stirred solution of 5-bromo-1-methyl-1H-pyrrolo [2, 3-bj pyridine (350 mg, 3 mmol) in 1,4-dioxane: water (4:1, 2.5 mL) at room temperature under an argon atmosphere were added lithium hydroxide (445 mg, 10 mmol), cyclopropylboronic acid (455 mg, 5 mmol) and Pd(dppf)2C12 (193 mg, 0.26 mmol). The reaction mixture was stirred at 120 C for 4 h in a sealed tube. After consumption of starting material (by TLC), the reaction mixture was filtered, the filtrate was diluted with water (20 mL) and extracted with EtOAc (2 x 20 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by column chromatography using 10- 20% EtOAc: Hexane to afford 5-cyclopropyl-1-methyl-1H-pyrrolo [2, 3-bj pyridine (120 mg, 26%) as colorless liquid. ?H NMR (CDC13,. 400 MHz): 8.20 (s, 1H), 7.56 (s, 1H), 7.13 (d, 1H), 6.36 (d, 1H), 3.87 (s, 3H), 2.05-2.02 (m, 1H), 1.00-0.94 (m, 2H), 0.73-0.68 (m, 2H); LCMS: 62.8%; 172.8 (M+1); (column; Ascentis Express C-18 (50 x 3.0 mm, 2.7 jtm); RT 1.97 mm; mobile phase: 0.025% Aq TFA+5% ACN: ACN+5% 0.025% Aq TFA; T/B%:0.01/5, 0.5/5, 3/100, 5/100; flow rate: 1.2 mL/min) (Gradient); TLC: 20% EtOAc/ Hexane (R1: 0.5).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,183208-22-2, its application will become more common.

Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; HARRISON, Bryce, Alden; (273 pag.)WO2017/31325; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 13959-02-9 ,Some common heterocyclic compound, 13959-02-9, molecular formula is C6H4BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate AB: 3-[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethyI]isonicotinic acid3-bromoisonicotinic acid (730 mg, 3.61 mmol) and Cuprous Bromide (31 mg, 0.22 mmol) was suspended in an excess of diethyl malonate (30 ml). Sodium hydride (631 mg, 26.3 mmol, 55% in oil) was added in portions under argon. After addition the mixture was stirred for 2 hrs at 8O0C. The mixture was diluted with H2O and washed with TBDME (3 x 30 ml). The aqueous phase was acidified to pH 4 using cone. HCl and extracted with TBDME (3 x 30 ml). The combined organic layers (from 2nd extraction) were dried over Na2SO4 and evporated. The crude product was recrystallized from TBDME and Heptane affording 668 mg (66%) the title compound as a green solid. EPO APCI-MS m/z: 282.1 [MH+]

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13959-02-9, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; WO2007/30061; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 65-22-5, 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 65-22-5, blongs to pyridine-derivatives compound. Computed Properties of C8H10ClNO3

General procedure: The desired compounds 1a-g and 2a-f were prepared by reaction between pyridoxal hydrochloride (0.15 g, 0.74mmol) and the appropriate aromatic or heteroaromatic hydrazine or N-acylhydrazine (1.1 eq., 0.81mmol) in ethanol (10.0 mL). The reaction mixture was stirred for 1-48 hours at room temperature. After that, product was purified by wash-ing with cold ethanol (3.0 mL) and cold diethyl ether (3.0 mL), leading to the pure derivatives 1a-g and 2a-f as solid in 42-86% yields.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,65-22-5, its application will become more common.

Reference:
Article; Nogueira, Thais Cristina Mendonca; Cruz, Lucas Dos Santos; Lourenco, Maria Cristina; de Souza, Marcus Vinicius Nora; Letters in drug design and discovery; vol. 16; 7; (2019); p. 792 – 798;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 754131-60-7, Adding some certain compound to certain chemical reactions, such as: 754131-60-7, name is 3-Bromo-2-(bromomethyl)pyridine,molecular formula is C6H5Br2N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 754131-60-7.

To a solution of cis-4-phenylcyclohexanol (50.8 g) in THF (300 ml) was added 60%sodium hydride ( 17.29 g) at 0C, and the mixture was stirred for 30 min. To thereaction mixture was added 3-bromo-2-(bromomethyl)pyridine (72.3 g), and themixture was stirred at room temperature overnight. Saturated aqueous ammoniumchloride solution was added, and the mixture was extracted with ethyl acetate. Theextract was washed with saturated brine, dried over anhydrous magnesium sulfate andthe solvent was evaporated under reduced pressure. The residue was purified by silicagel column chromatography (ethyl acetate/hexane) to give the title compound (84.43g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 754131-60-7, 3-Bromo-2-(bromomethyl)pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FUJIMOTO Tatsuhiko; RIKIMARU Kentaro; FUKUDA Koichiro; SUGIMOTO Hiromichi; MATSUMOTO Takahiro; TOKUNAGA Norihito; HIROZANE Mariko; (166 pag.)WO2017/135306; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 796851-03-1 , The common heterocyclic compound, 796851-03-1, name is 2,5-Dichloro-4-iodopyridine, molecular formula is C5H2Cl2IN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

a) A mixture of 2,5-dichloro-4-iodopyridine (0.4Og, 1.46 mmol), 7-amino-2-methyl-4- (4-propan-2-ylpiperazin-l-yl)-3H-isoindol-l-one (0.421 g, 1.46 mmol), 9,9-dimethyl-4,5- bis(diphenylphosphino)xanthene (0.051 g, 0.09 mmol), cesium carbonate (0.952 g, 2.92 mmol) and palladium(II) acetate (0.013 g, 0.06 mmol) was suspended in DMA (15 mL). The mixture was heated at 1000C for 1 hour in a microwave reactor and then allowed to cool to room temperature. The mixture was loaded onto an SCX column and the product eluted first with MeOH and then with a 7M solution of NH3 in MeOH. Fractions containing product were combined and evaporated to afford 7-[(2,5-dichloropyridin-4- yl)amino]-2-methyl-4-(4-propan-2-ylpiperazin-l-yl)-3H-isoindol-l-one (0.630 g, 99% yield); 1H NMR spectrum: (300 MHz, DMSO) delta 1.01 – 1.18 (3H, d), 2.60 – 2.64 (4H, m), 3.04 – 3.09 (5H, m), 4.51 (2H, s), 7.16 (IH, d), 7.29 (IH, s), 7.50 (IH, d), 8.28 (IH, s), 9.59 (IH, s); Mass spectrum: m/z (ESI+) (M+H)+ = 434.0 and 436.0 and 438.0.

The synthetic route of 796851-03-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/153589; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 132813-14-0 , The common heterocyclic compound, 132813-14-0, name is 2-Chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine, molecular formula is C17H17ClFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The inside of a 200 mL flask was placed under a nitrogen atmosphere, and 33.5 mL of toluene and 5.91 g (51.77 mmol) of 1-ethylpiperazine were added and stirred. After cooling to 10 C, 5.00 g (17.26 mmol) of 2-chloro-4- (4-fluorophenyl) -5,6,7,8,9,10-hexahydrocyclo octa [b] pyridine and 1.99 g (20.71 mmol) of sodium-tert-butoxide were added. After reducing the pressure at 100 hPa or less and stirring for 2 minutes, the operation of restoring pressure with nitrogen was repeated 5 times. After adding 0.0775 g (0.345 mmol) of palladium (II) acetate and 0.2715 g (1.035 mmol) of triphenylphosphine, the mixture was depressurized at 100 hPa or less, stirred for 2 minutes, and then pressure restoration with nitrogen was performed three times, and the mixture was stirred under 70 C for 7 hours. The reaction solution was cooled to room temperature, 50 mL of water was added little by little, and after stirring for 30 minutes, the precipitate was removed by filtration using phi 40 mm Kiriyama funnel mounted with 2.50 g of Celite, and washed twice with 10 mL of toluene . The obtained filtrate was transferred to a 300 mL separatory funnel and the aqueous layer was removed (pH 13.0). Water (50 mL) was added to the organic layer, shaken vigorously for 2 minutes, allowed to stand for 10 minutes, and the aqueous layer was removed. This washing operation was repeated until the aqueous layer pH was 9 or less, to obtain a blonanserine toluene solution (49.86 g). Blonanserin content: 5.67 g, reaction yield: 89.12%, HPLC purity: 87.70%.49.86 g (blonanserin 5.67 g, 15.43 mmol) of the toluene solution of bronan serine obtained in Step 1 was added to a 200 mL flask, 25 mL of toluene was added, and the mixture was added at 50 C. and 50 to 70 hPa The mixture was concentrated under reduced pressure in an amount corresponding to toluene to prepare 54.64 g of a toluene solution of blonanserin.Separately from the above, a 200 mL flask was prepared and under a nitrogen atmosphere, 50 mL of ethanol was added and the mixture was cooled to 10 C., and 3.38 g (34.51 mmol) of 98% sulfuric acid was slowly added dropwise thereto to prepare a sulfuric acid ethanol solution .The bronan serine toluene solution transferred to the 100 mL dropping funnel was slowly added dropwise to the stirred ethanol sulfuric acid solution while keeping the inside of the system at 0 to 10 C. and stopped when 1/5 amount was added dropwise, and 0.5 mg of bronanserin sulfate seed crystals The mixture was stirred for 30 minutes when solid precipitation was confirmed.Thereafter, the remaining 4/5 amount of dropwise addition of the toluene solution of bronan serine was restarted, and after completion of the dropwise addition, it was washed with 5 mL of toluene and stirred at 0 to 10 C. for 30 minutes.The precipitated solid was filtered with a phi 40 mm Kiriyama funnel, the cake was washed twice with 25 mL of cold toluene and dried on a Kiriyama funnel for 30 minutes to obtain 8.67 g of a light red solid.HPLC purity: 99.40%.Step 3 Recrystallization of Blonanserin Sulfate A300 mL flask was placed under a nitrogen atmosphere, 8.66 g (15.36 mmol) of the bronnan serine sulfate obtained in Step 2, 125 mL ethanol and 2.50 mL water were added and heated to reflux to obtain a uniform solution .The mixture was cooled to an internal temperature of 10 C. over 2 hours and 30 minutes and stirred at 0 to 10 C. for 30 minutes.The precipitated solid was filtered with a phi 40 mm Kiriyama funnel, the cake was washed twice with cold ethanol 15 mL, and dried on a Kiriyama funnel for 30 minutes to obtain 6.76 g of an off white solid.HPLC purity: 99.98%.

The synthetic route of 132813-14-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DAI NIPPON PRINTING COMPANY LIMITED; YONEYAMA, TAKUYA; ONOZAWA, TAKASHI; (10 pag.)JP2018/127406; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 15862-37-0, Adding some certain compound to certain chemical reactions, such as: 15862-37-0, name is 2,5-Dibromo-3-nitropyridine,molecular formula is C5H2Br2N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15862-37-0.

To a solution of 2,5-dibromo-3-nitropyridine (5.00 g, 17.8 mmol) in EtOH (20 mL), water (27 mL) and toluene (30 mL) was added thiophen-3 -ylboronic acid (2.39 g, 18.7 mol) and Na2CO3 (5.68 g, 53.6 mol) under N2. The mixture was purged with N2 for 2 mm and followed by addition of tetrakis(triphenylphosphine)palladium (1.04 g, 0.900 mmol). The reaction mixture was heated to reflux for 16 h. Then the reaction mixture was cooled to r.t.and extracted with EtOAc (100 mL). The collected organic phase was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography using 0-5% EtOAc in hexane to afford the title compound (3.84 g, 76% yield) as a light yellow solid. LC-MS [M+H]= 286.

According to the analysis of related databases, 15862-37-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; JACOBIO-BETA PHARMACEUTICALS CO., LTD.; JACOBIO-ALPHA PHARMACEUTICALS CO., LTD.; JACOBIO PHARMACEUTICALS CO., LTD.; FANG, Haiquan; ZHOU, Wenlai; HU, Shaojing; CHEN, Mingming; YANG, Guiqun; WANG, Yanping; DU, Yuelei; LI, Qinglong; WU, Tong; WU, Lingjun; LI, Haijun; LONG, Wei; (179 pag.)WO2019/80941; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17282-40-5, name is 1-(2-Ethoxy-2-oxoethyl)pyridin-1-ium bromide, molecular formula is C9H12BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyridine-derivatives

General procedure: Chromenone 1a (0.5 mmol), pyridinium salts 2a (0.55 mmol), DBU (1.0 mmol) and 1,4-dioxane (3.0 mL) were dissolved in 10 mL round-bottomed flask and stirring at 80 C for 12 h. The reaction was monitored by TLC. After completion of reaction, the reaction mixture was cooled down to room temperature and concentrated in vacuum to give the crude product, which was further purified by silica gel chromatography (ethyl acetate: petroleum =1:5) to afford the desired product. 1.

With the rapid development of chemical substances, we look forward to future research findings about 17282-40-5.

Reference:
Article; Dong, Kai-Kai; Huang, Qiang; Tetrahedron Letters; vol. 60; 29; (2019); p. 1871 – 1874;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 885276-93-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 885276-93-7, name is Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate. A new synthetic method of this compound is introduced below.

Synthesis of 5-bromo-N, N-bis(4-methoxybenzyl)pyrazolo[ 1 , 5-a]pyridine-3-carboxamide-26)1-25 1-26[000270] To a suspensions of ethyl 5-bromopyrazolo[1 ,5-a]pyridine-3-carboxylate (0.27 g, 1 .0 mmol) in EtOH (5 ml_) was added 6 N KOH (0.3 uL, 2.0 mmol). The reaction was heated to reflux for 3 hours then cooled to room temperature and neutralized to pH 6 with 1 M HCI. The resulting solid was filtered and dried under vacuum to yield 5-bromopyrazolo[1 ,5-a]pyridine-3-carboxylic acid (I-25) as a white solid. 1 H NMR (400MHz, DMSO-c/6) delta 8.83 (d, J = 7.6 Hz, 1 H), 8.42 (s, 1 H), 8.21 (d, J = 2.4 Hz, 1 H), 7.30 (dd, J = 2.0, 7.6 Hz, 1 H). MS m/z 240.9, 242.9 (M+1 )+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,885276-93-7, its application will become more common.

Reference:
Patent; IRM LLC; MOLTENI, Valentina; FAN, Yi; LOREN, Jon; SMITH, Jeffrey M.; FLATT, Brenton T.; WO2012/116217; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem