Tag: M.W:200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 929000-66-8, name is 3-Bromo-6-chloropyridine-2-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 3-Bromo-6-chloropyridine-2-carboxylic acid

A) methyl 3-bromo-6-chloropyridine-2-carboxylate To a solution of 3-bromo-6-chloropyridine-2-carboxylic acid (5.00 g) in methanol (90 mL) was added 98% sulfuric acid (889 mg), and the mixture was stirred at 60C for 16 hr. The reaction mixture was cooled to room temperature, and the solvent was evaporated under reduced pressure. The obtained residue was dissolved in ethyl acetate, the solution was washed with saturated aqueous sodium hydrogencarbonate solution and saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (5.05 g). 1H NMR (400 MHz, DMSO-d6) delta 3.93 (3H, s), 7.70 (1H, d, J = 8.4 Hz), 8.32 (1H, d, J = 8.4 Hz).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 929000-66-8, 3-Bromo-6-chloropyridine-2-carboxylic acid.

Reference:
Patent; Takeda Pharmaceutical Company Limited; YOGO, Takatoshi; YOSHIKAWA, Masato; SAITOH, Morihisa; KATOH, Taisuke; SEKI, Tomohiro; NAKADA, Yoshihisa; (148 pag.)EP3366684; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

5470-17-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5470-17-7, name is 3-Bromo-2-chloro-5-nitropyridine. A new synthetic method of this compound is introduced below.

34b. 3-bromo-2-methyl-5-nitropyridine A solution of diethyl malonate (17.6 mL, 0.116 mol) in diethyl ether (250 mL) at ambient temperature was treated with sodium hydride (80% in mineral oil, 3.5 g, 0.116 mol), and the mixture was stirred for 1 hour. Then 3-bromo-2-chloro-5-nitropyridine (25 g, 105 mmol; prepared from 2-hydroxy-5-nitropyridine according to the procedure of V. Koch and S. Schnatterer, Synthesis 1990, 499-501) was added in portions over 5 minutes. After the mixture had stirred for 1 hour, the solvent was evaporated, and the residue was heated at 100 C. for 1 hour. After the mixture had cooled, 12 N H2 SO4 was added, and the mixture was heated at reflux for about 16 hours. The mixture was allowed to cool to ambient temperature, then further cooled as it was treated with 50% NaOH to give an alkaline pH. The resulting solution was extracted with CHCl3 (3*), and the organic extracts were washed with H2 O, dried (MgSO4) and evaporated to afford 17.1 g of the title compound as a red oil: 1 H NMR (CDCl3, 300 MHz) delta 2.81 (s, 3H), 8.61 (d, J=2 Hz, 1H), 9.26 (d, J=2 Hz, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5470-17-7, 3-Bromo-2-chloro-5-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Abbott Laboratories; US6133253; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

15862-34-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15862-34-7, name is 5-Bromo-2-hydroxy-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

Method B: to a suspension of 14 (5.0 g, 22.8 mmol) in anhydrous CH3Cl (50 mL) under N2 in the dark (wrapped in aluminum foil) was added Ag2CO3 (7.55 g, 28.0 mmol), followed by CH3I (14.2 mL, 230.0 mmol). After stirring at rt for 48 h, the reaction mixture was filtered through a pad of Celite, washed with abundant CH2Cl2, and concentrated in vacuo. The crude product was purified by silica gel column chromatography (10:1 hexanes/EtOAc) to afford 16 (1.86 g, 34%) as a pale yellow solid. The analytical data were same as aforementioned.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 15862-34-7, 5-Bromo-2-hydroxy-3-nitropyridine.

Reference:
Article; Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang; Bioorganic and Medicinal Chemistry Letters; vol. 22; 4; (2012); p. 1569 – 1574;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

26218-75-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26218-75-7, name is Methyl 6-bromopicolinate. This compound has unique chemical properties. The synthetic route is as follows.

In a nitrogen atmosphere, 30 mL of 3 M methylmagnesium iodide/diethyl ether was added to 300 mL of diethyl ether solution of 8.72 g of methyl 6-bromopyridine-2-carboxylate. Water and 2 N hydrochloric acid were added to the reaction liquid, and extracted with ethyl acetate. This was washed with aqueous saturated sodium hydrogencarbonate solution and saturated saline water, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure to obtain crude 2-(6-bromo-2-pyridinyl)-2-propanol as a yellow oily substance. 1H-NMR (400 MHz, CDCl3) delta: 7.56 (1H, t, J=7.8 Hz), 7.38 (1H, dd, J=7.8, 1.0 Hz), 7.36 (1H, dd, J=7.8, 1.0 Hz), 1.55 (6H, s). ESI-MS Found: m/z[M+H]+ 216, 218.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 26218-75-7, Methyl 6-bromopicolinate.

Reference:
Patent; Merck Sharp & Dohme Corp.; Shumway, Stuart Denham; (37 pag.)US2016/8361; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

624-28-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 624-28-2 as follows.

A 12L three-necked round-bottomed flask equipped with a mechanical stirrer and a condenser, connected on top with a nitrogen [BUBBLER] and a thermometer, was charged with 2,5-dibromopyridine (442 g, 1. [87MOLES),] hydrazine hydrate (55% wt., 1057 ml, [18.] 7 moles), poly (ethylene glycol) (average Mn about 300,1. 87 L), 2-butanol (373 [ML)] and water (1.87 L). The mixture was heated at reflux for 29 hours. The heating source was removed and the mixture was stirred for an additional 20 hours. To the resulting slurry, cold water [(2.] 2L) was added. The slurry was stirred for an additional [30] minutes and filtered. The cake was washed with cold water (3 x [200] [ML)] and dried in a vacuum-oven [(40C)] for 48 hours. The title compound was obtained as off-white flakes (305 g, yield 87%). GCMS (m/z): 187 (M+). [H’NMR] (400 MHz, [CDCI3)] : 8 8.14 (d, J=2.0 Hz, 1H), 7.55 (dd, J=8.7/2. 0 Hz, 1 H), 6.66 (d, J=8.7Hz, [1 H),] 5.89 (brs, 1 H), 3.65 (brs, 2H).

The chemical industry reduces the impact on the environment during synthesis 624-28-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2004/20438; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is C8H11Cl2NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 72830-09-2

To the reaction flask was added 10 g of 2-chloromethyl-3,4-dimethoxypyridine hydrochloride(Compound 1), 10 g of 5-difluoromethoxy-2-mercapto-1H-benzimidazole(Compound 2), 100 ml of methylene chloride was added, and 130 g of a 10% sodium hydroxide solution was added dropwise, and the mixture was stirred at 20 to 30 C for 2 hours, Static separation, dichloromethane layer washed twice, each time with water 30ml,And then distilled under reduced pressure to give 16.6 g of a yellow oil (Intermediate 3);

The chemical industry reduces the impact on the environment during synthesis 72830-09-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Qilu Tianhe Huishi Pharmaceutical Co., Ltd.; Qin Chunxia; Li Baoyong; Wu Ke; Zhang Zhaozhen; Dong Tinghua; (6 pag.)CN105111187; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1604-14-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1604-14-4, name is 2,6-Dichloro-isonicotinic acid ethyl ester. A new synthetic method of this compound is introduced below.

A solution of phenylboronic acid (915 mg, 7.50 mmol) in methanol (15 mL) was added to a stirred solution of ethyl-2,6- dichloro-isonicotinate (750 mg, 3.41 mmol) and tetrakis- (TRIPHENYLPHOSPHINE)-PALLADIUM (0) (197 mg, 5 mol%) in toluene (60 mL). 2N sodium carbonate (3.41 mL, 6.82 mmol) was added and the reaction was heated to 90C (oil bath temp. ) for 2-3 hrs until complete (TLC control). The reaction mixture was cooled to room temperature and partitioned between water and diethyl ether. The phases were separated, the aqueous phase being further extracted with diethyl ether (3 x 30 mL). The combined extract was washed with water and brine. The ethereal solution was dried over anhydrous MGS04, filtered and concentrated in vacuo to yield the title compound as a white solid (941 mg, 91 %) ; Rf: 0.5 (30% ethyl acetate in heptane); 1H NMR (CDC13, 300 MHz) 6 8.18 (2H, s, ArH), 8.12 (4H, m, ArH), 7.42 (6H, m, ArH), 4.38 (2H, q, J = 7 Hz, CH20), 1.39 (2H, t, J = 7HZ, CH3).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1604-14-4, 2,6-Dichloro-isonicotinic acid ethyl ester, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE INSTITUTE OF PHARMACEUTICAL DISCOVERY, LLC; WO2004/99192; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

624-28-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 624-28-2, name is 2,5-Dibromopyridine. A new synthetic method of this compound is introduced below.

A mixture of 2,5-dibromopyridine (28.6 g, 121 mmol) and (S)-3-hydroxypyrrolidine (10.0 g, 115 mmol) in dry toluene (150 mL) was stirred under reflux for 20 h. The mixture was allowed to cool to rt, and the solvents were removed under reduced pressure. The residue was dissolved with EtOAc, and the resulting mixture was washed with aq. 10% K2CO3. The org. layer was dried over MgSO4, filtered, and the solvents were concentrated under reduced pressure. Purification of the residue by FC(CH2Cl2/MeOH 99:1?98:2?97:3?96:4?95:5?94:6?93:7) yielded the title compound (15.39 g, 55%). LC-MS: tR=0.45 min; ES+: 245.11.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,624-28-2, 2,5-Dibromopyridine, and friends who are interested can also refer to it.

Reference:
Patent; Actelion Pharmaceuticals, Ltd.; US2009/88457; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

624-28-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 624-28-2, name is 2,5-Dibromopyridine. This compound has unique chemical properties. The synthetic route is as follows.

Preparation 55 4-(5-Bromo-pvridin-2-vl)-morpholine; 2,5-Dibromopyridine (7.1 g, 30 mmol), morpholine (1.74 mL, 20 mmol), cesium carbonate (9.1 g, 28 mmol), tris (dibenzylideneacetone) dipalladium (0) (183 mg, 0.2 mmol), and racemic 2,2′-bis (diphenylphosphino)-1, 1′-binaphthyl (374 mg, 0.6 mmol) in toluene (20 mL) was heated at 120C for 24 hours. After cooling to room temperature, the mixture was filtered through CeliteT””and the Celte tu pad was washed with chloroform. The solution was concentrated in vacuo and was purified by silica gel chromatography (200: 1 chloroform- methanol) to give 2.9 g (60% yield) of the title compound. 13C NMR (100 MHz, CD03) d 158.3, 148. 7, 140.0, 108. 4, 66.8, 45.7 ; MS (AP/Cl) 243.0, 245.0 (M+H) +

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 624-28-2, 2,5-Dibromopyridine.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2005/90300; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 571188-59-5, name is tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. 571188-59-5

900 mg of Compound 5 was dissolved in 10 mL of toluene solution. Add 4 mL of 1 mol/L LiHMDS at 0~10 CA solution of tetrahydrofuran was stirred for 1 h. Add 450 mg of compound 1 in toluene at 0~10 C and slowly return to room temperature.2.5h. After the end of the HPLC monitoring reaction, the reaction was quenched with 9 mL of saturated ammonium chloride, and the organic phase was separated, using anhydrous sulfuric acid.The sodium was dried, and the filtrate was collected by filtration.86%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,571188-59-5, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; Suzhou Pengxu Pharmaceutical Technology Co., Ltd.; Li Pixu; Wang Peng; Wei Qiang; (7 pag.)CN109553621; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem