Tag: M.W:200-300

624-28-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 624-28-2, name is 2,5-Dibromopyridine. This compound has unique chemical properties. The synthetic route is as follows.

Intermediate 16: N-methyl-5-(tributylstannyl)pyridin-2-amine 2,5-Dibromopyridine (6 g, 25 mmol) in 40 ml 33% CH3NH2 in ethanol (13 eq.) was heated at 80 C. for 60 hours. After evaporation the solid residue was suspended in CH2Cl2, extracted 3* with 1 N HCl. The combined aqueous phase was neutralized with 2 N NaOH (pH-10-11), and then back extracted 3* with CH2Cl2. The combined CH2Cl2 phase was washed with water and dried over sodium sulfate. Concentration gave 4.457 g of 5-bromo-N-methylpyridin-2-amine as off-white solid. (yield: 95.3%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 624-28-2, 2,5-Dibromopyridine.

Reference:
Patent; MacDonald, James E.; Jeffrey, McKelvy F.; Wong-Staal, Flossie; US2011/117055; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

571188-59-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 571188-59-5 as follows.

To a 500 ml round bottom flask was added 16.8 g of compound 7 (50 mmol).18.4 g of compound 8 (60 mmol) was dissolved in 350 ml of toluene and refluxed. After the reaction was completed,The solvent was evaporated under reduced pressure and the residue was dissolved in methanol (300 ml).Adding dilute hydrochloric acid to room temperature reaction,After the reaction is completed, it is alkalized to pH>10 with dilute aqueous ammonia, extracted with ethyl acetate, and washed with saturated brine.Dried over anhydrous sodium sulfate and concentrated to give a white solid compound.The target product after recrystallization (1) 14 g, 65%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,571188-59-5, its application will become more common.

Reference:
Patent; Southwest University for Nationalities; Song Lei; (9 pag.)CN108623599; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

571188-59-5, Adding a certain compound to certain chemical reactions, such as: 571188-59-5, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 571188-59-5, blongs to pyridine-derivatives compound.

In a 250 ml round bottom flask,Was added 2-chloro-7-cyclopentyl–N, N- dimethyl–7H- pyrrolo [2,3-d] pyrimidine-6-carboxamide and 14.6g (50mmol),Tert-Butyl 4- (6-aminopyridin-3-yl) piperazine-1-carboxylate15.3 g (55 mmol),0.67 g (3 mmol) of Pd (OAc) 2,BINAP 1.2 g (2 mmol),Cs2CO3 65.1g (200mmol) and 130ml 1,4-dioxane, warmed to 90 C, the reaction was stirred for 8 hours,The reaction was monitored, concentrated under reduced pressure and flash column chromatographyA solution of 4- (6- (7- (dimethylcarbamoyl) -7H-pyrrolo [2,3-d] pyrimidin- 2-ylaminopyridin-3-yl) – carboxylic acid tert-butyl ester.The above obtained solution of 4- (6- (7- (dimethylcarbamoyl) -7H-pyrrolo [2,3-d] pyrimidin- 2-ylaminopyridin-3-yl) – carboxylic acid tert-butyl esterDissolved in 100ml of toluene,Add 30ml 6mol / L hydrochloric acid, and stirred at room temperature for 2 hoursThe reaction was monitored completely, adjusted to pH 8 with sodium hydroxide, extracted with methylene chloride, washed with brine and driedThe organic phase was dried over sodium sulfate, concentrated under reduced pressure,N-hexane to obtain Ribociclib 18.2g, the yield was 83.7%

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,571188-59-5, its application will become more common.

Reference:
Patent; Tsingtao Chenda Biological Technology Co., Ltd.; Chen Linghao; (8 pag.)CN106928236; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is C8H11Cl2NO2, molecular weight is 224.08, as common compound, the synthetic route is as follows.72830-09-2

1.5 equiv of 2-chloromethyl pyridine hydrochloride, 1.5 equiv of K2CO3 and 0.15 equiv of KI were added to a magnetically stirred solution of 1.0 equiv of 5 or 12 (2.0mmol) in a mixture of acetone (15 mL) and EtOH (15 mL). The reaction mixture was stirred constantly at 45 C for about 4 h. When the reaction was finished, as monitored by HPLC-MS, enough water (50 mL) was added. Then the reaction mixture was extracted with DCM (20 mL ¡Á 3). The organic phase was combined and concentrated under reduced pressure to give crude compound 6 or 13. For a typical compound of 6, for example, 2-[(3,4-dimethoxypyridin-2-yl)methylthio]-6-nitro-5-(piperidin-1-yl)-1H-benzimidazole, the orange powder was obtained in 91% yield, with an HPLC purity >98%.

Statistics shows that 72830-09-2 is playing an increasingly important role. we look forward to future research findings about 2-Chloromethyl-3,4-dimethoxypyridinium chloride.

Reference:
Article; Yan, Yu; Liu, Zijie; Zhang, Jianjun; Xu, Ruiming; Hu, Xiao; Liu, Gang; Bioorganic and Medicinal Chemistry Letters; vol. 21; 14; (2011); p. 4189 – 4192;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

624-28-2 , The common heterocyclic compound, 624-28-2, name is 2,5-Dibromopyridine, molecular formula is C5H3Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 1: 5-Bro -2-methoxypyridine A mixture of 2,5-dibromopyridine (5.5 g, 23.2 mmol) and NaOMe (3.76 g, 69.6 mmol) in MeOH (60 mL) was heated at 70C for 1 hour and then allowed to cool to room temperature. The reaction mixture was diluted with water (50 mL) and extracted with EtOAc (2 x 100 mL). The combined organic layers were dried over Na2S04 and concentrated under reduced pressure to give a pale yellow volatile oil (2.5 g, 58% yield). 1H NMR (400 MHz, DMSO-d6): delta 8.26 (s, 1H), 7.87 (dd, 1H), 6.81 (d, 1H), 3.82 (s, 3H).

The synthetic route of 624-28-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ENDO PHARMACEUTICALS INC.; SMITH, Roger, Astbury; KETHIRI, Raghava, Reddy; KRISTAM, Rajendra; LAPING, Nicholas, James; VENKATESHAPPA, Chandregowda; KULKARNI, Bheemashankar; DEVRAJ, Rajesh; DEWANG, Purushottam; WO2013/49559; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 571188-59-5, name is tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate, molecular formula is C14H22N4O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 571188-59-5

Toluene (432.0 mL) and 4-(6-amino-pyridine-3-yl)-piperazine-l -carboxylic acid tert-butyl ester (34.3g, 0.123 moles) were charged into 2L 4N RB flask under nitrogen atmosphere at 30¡À5C and stirred for 5-10 min to get brown colored suspension. Reaction mass was cooled to 0¡À5C. Lithium hexamethyldisilazane 1M solution in THF (259.0 mL, 0.258 moles) was added dropwise to the reaction mass through addition funnel by maintaining the reaction mass temperature at 0 ¡À5C. And stirred the reaction mass for 10-15 min at 0 ¡À 5Cto get clear brown colored solution. Add the solution of 2-chloro-7-cyclopentyl-N,N-dimethyl-pyrrolo[2,3-d]pyrimidine- 6-carboxamide (36.0g, 0.123 moles) in 324.0 mL of toluene dropwise to the reaction mass through addition funnel at 0 ¡À5C. Reaction mass temperature was raised to 25- 35C and stirred for lh for reaction completion. (0107) After completion of reaction (by TLC), solvent was distilled off on rotavapor under vacuum at 55-60C to get the brown colored solid. DM water (360.0 mL) and aq. sodium bicarbonate solution (36.0g of sodium bicarbonate was dissolved in 720.0 mL of DM water) were added to the above solid and stirred for 10-15 min. Then methylene chloride (720 mL) was charged to the above solution and stirred for 5-l0min. Layers were separated. Organic layer washed with DM water (720 mL) and layers Separated. Solvent was distilled off from organic layer completely under vacuum at 45-50C on rotavapor to obtain brown colored solid. The solid was leached with methanol (180 mL) at 30 ¡À 5C to afford title compound as pale brown colour solid. Weight of the product: 57.0g (86.6% by theory). Purity by HPLC > 98.0%. (0108) H1 NMR (DMSO-d6): d 9.412 (S, 1 H), 8.167-8.190 (d, 2 H), 8.02-8.03 (d, 1 H), 7.449-7.479 (dd, 1 H), 6.603 (S, 1 H), 4.690-4.778 (m, 1 H), 3.472-3.484 (d, 4 H), 3.062-3.073 (d, 10H), 2.413-2.465 (m, 12 H), 1.92-1.991 (m, 4 H), 1.427-1.65 (m, 10H); Mass m/z (M+l): 535.25

The chemical industry reduces the impact on the environment during synthesis 571188-59-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; NATCO PHARMA LIMITED; ARUNKUMAR, Thiriveedhi; SWAPNA, Kondaveeti; SATHISH, Thumati; NARESH, Ghanta; JANAKI RAMA RAO, Ravi; DURGA PRASAD, Konakanchi; PULLA REDDY, Muddasani; VENKAIAH CHOWDARY, Nannapaneni; (36 pag.)WO2019/142206; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

69045-84-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a suspension of NaH (0.043 g, 1.8 mmol, 4 equiv) in anhyd THF (2mL) at 0 C was added dropwise a solution of ethyl 6-methyl-7-oxo-2,3-dihydro-1H-pyrazolo[1,5-a]pyrimidin-1-ium-5-carboxylate 2,2,2-trifluoroacetate (38; 0.15 g, 0.44 mmol) in DMF (0.5 mL). After stirring the reaction mixture for 10 min, 2,3-dichloro-5-(trifluoromethyl)pyridine (0.115 g, 0.53 mmol, 1.2 equiv) was added dropwise, followed by the addition of THF (6 mL) and DMF (1.5 mL). The reaction mass was stirred for 1 h at r.t., then acidified with aq 2 N HCl, and extracted with EtOAc (3 ¡Á 50 mL). The combined organic layers were washed with brine, dried (Na2SO4), and concentrated under reduced pressure to obtain a crude mass. Trituration with Et2O and cooling to0 C afforded the desired product 39 as an off-white solid; yield: 0.135g (81%); mp 185-187 C.IR (KBr): 2922, 1734, 1672, 1554, 1323, 1136, 1051 cm-1.1H NMR (400 MHz, DMSO-d6): delta = 2.04 (s, 3 H), 3.20-3.44 (m, 8 H),4.16 (br t, J = 7.40 Hz, 2 H), 8.58-8.61 (m, 1 H), 8.65 (s, 1 H), 13.39-13.88 (m, 1 H).13C NMR (100 MHz, DMSO-d6): delta = 166.5, 157.7, 156.9, 156.2, 149.7,142.5, 136.5, 123.8, 123.0, 122.7, 121.4, 121.1, 119.9, 51.3, 30.3, 11.1. HRMS-ESI: m/z calcd for C14H10ClF3N4O3 (M + H): 375.0472; found:375.0465.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine.

Reference:
Article; Shirsale, Ashwini; Patil, Yogesh; Rawal, Girish K.; Pabba, Jagadish; Berthon, Guillaume; Sonawane, Ravindra P.; Sikervar, Vikas; Synthesis; vol. 50; 10; (2018); p. 2087 – 2093;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

624-28-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 624-28-2, name is 2,5-Dibromopyridine. A new synthetic method of this compound is introduced below.

Step 1 5-Bromo-2-methoxypyridine To a solution of 2,5-dibromopyridine (1.4 g, 5.9 mmol) in DMF (10 mL) was added MeOH (4 mL), and 8N aqueous KOH (1 mL). The solution was heated to 100 C. for 2 h, then cooled and partitioned between Et2 O and H2 O. The organic layer was washed with brine, dried over MgSO4 and concentrated to provide 840 mg of the title compound, which was used in the next step without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 624-28-2, 2,5-Dibromopyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Merck Frosst Canada; US5922742; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1604-14-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1604-14-4, name is 2,6-Dichloro-isonicotinic acid ethyl ester, molecular formula is C8H7Cl2NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of phenylboronic acid (915 mg, 7.50 mmol) in methanol (15 mL) was added to a stirred solution of ethyl-2,6-dichloro-isonicotinate (750 mg, 3.41 mmol) and tetrakis-(triphenylphosphine)-palladium(0) (197 mg, 5 mol %) in toluene (60 mL). 2N sodium carbonate (3.41 mL, 6.82 mmol) was added and the reaction was heated to 90 C. (oil bath temp.) for 2-3 hrs until complete (TLC control). The reaction mixture was cooled to room temperature and partitioned between water and diethyl ether. The phases were separated, the aqueous phase being further extracted with diethyl ether (3¡Á30 mL). The combined extract was washed with water and brine. The ethereal solution was dried over anhydrous MgSO4, filtered and concentrated in vacuo to yield the title compound as a white solid (941 mg, 91%); Rf: 0.5 (30% ethyl acetate in heptane); 1H NMR (CDCl3, 300 MHz) delta 8.18 (2H, s, ArH), 8.12 (4H, m, ArH), 7.42 (6H, m, ArH), 4.38 (2H, q, J=7 Hz, CH2O), 1.39 (2H, t, J=7 Hz, CH3).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1604-14-4, 2,6-Dichloro-isonicotinic acid ethyl ester, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; The Institutes for Pharmaceutical Discovery, LLC; US2006/122222; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

69045-84-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

(1) The preparation of intermediate IV-2 [Show Image] 11.8 g (60 mmol) of piperazine hexahydrate was added to a 150 mL flask with 40 mL acetonitrile, heated to 40 C, 10.8 g (50 mmol) of 2,3-dichloro-5-(trifluoromethyl)pyridine was added dropwise to the solution in 15 min, then 9 mL triethylamine was added to the mixture and stirred at 40 C for 4 h. The reaction was monitored by TLC, upon completion, filtrated and washed by a little ethanol to obtain 12 g white solid (90.2% yield).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine.

Reference:
Patent; Sinochem Corporation; Shenyang Research Institute of Chemical Industry Co., Ltd.; EP2281810; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem