Tag: M.W:200-300

Adding a certain compound to certain chemical reactions, such as: 947249-13-0, 5-Bromo-3-(difluoromethoxy)pyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

A mixture of 5-bromo-3-(difluoromethoxy)pyridine-2-amine (88mg, 0.37 mmol), bis(pinacolato)diboron (102mg, 0.40 mmol), potassium acetate (0.215mg, 2.2 mmol), and Pd(dppf)-CH2C12 (30mg, 0.037mmol) in dry dioxane (2.0 mL) was sparged with argon, and heated at 12O0C for 30 min. After cooling to rt, the reaction mixture was centrifuged and the supernatant decanted, and used in the next step without further purification: LCMS (m/z, MH+, boronic acid): 205.0, R = 0.27min.

The synthetic route of 947249-13-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; WO2009/115572; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 54718-39-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.54718-39-7, name is 2,5,6-Trichloronicotinic acid, molecular formula is C6H2Cl3NO2, molecular weight is 226.4446, as common compound, the synthetic route is as follows.

The following may be mentioned as preferred compounds of the general formula (I) which can be prepared by the process according to the invention: … 2-chloro-5-methoxymethyl-pyridine 2-chloro-5-ethoxymethyl-pyridine methyl 6-chloro-nicotinate ethyl 6-chloro-nicotinate N,N-dimethyl-6-chloro-nicotinamide 2-chloroquinoline 1-chloroisoquinoline

Statistics shows that 54718-39-7 is playing an increasingly important role. we look forward to future research findings about 2,5,6-Trichloronicotinic acid.

Reference:
Patent; Bayer Aktiengesellschaft; US5334724; (1994); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 75806-86-9 ,Some common heterocyclic compound, 75806-86-9, molecular formula is C5H2BrClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 2-bromo-5-chloro-3-nitropyridine (2.8 g; 11.79 mmol) and copper(I) cyanide (1.40 g, 15.63 mmol) in DMF (30 mL)was stirred at 110C for 1.5 h. The mixture was concentrated. The residue was diluted with water (60 mL), extracted three times with EtOAc (50 mL). The organic phase was washed with brine, dried over Na2SO4, filtered and concentrated. The residue was purified by columnchromatography (elution: DCM/Petroleum ether 1/1). The desired fractions were collected and concentrated to give 1.10 g of intermediate 521 (51% yield) as a yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75806-86-9, its application will become more common.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier Alexis Georges; GROSS, Gerhard Max; JACOBY, Edgar; MEERPOEL, Lieven; KULAGOWSKI, Janusz Jozef; MACLEOD, Calum; MANN, Samuel Edward; GREEN, Simon Richard; HYND, George; (476 pag.)WO2017/125534; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 915107-31-2, name is Methyl 6-chloro-5-methoxynicotinate. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 915107-31-2

To a solution of 6-chloro-5-methoxynicotinic acid methyl ester (1.3 g, 6.4 mmol) in MeOH (4 mL) at 25 C. was added 10% NaOH aqueous solution (19.3 mmol). The reaction was stirred for 24 h, then placed into an ice water bath and acidified with 2M HCl until pH=2 was achieved. The flask was then placed into a refrigerator for 3 h. The white precipitate was filtered off and rinsed with cold H2O. The solid was dissolved in acetone, dried over MgSO4 and concentrated to furnish the product 6-chloro-5-methoxynicotinic acid as a yellow solid (0.895 g, 74%); 1H NMR (400 MHz, CDCl3) delta 8.45 (d, 1H), 7.66 (d, 1H), 3.83 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 915107-31-2, Methyl 6-chloro-5-methoxynicotinate.

Reference:
Patent; Zhu, Yuanming; Loso, Michael R.; Nugent, Benjamin M.; Huang, Jim X.; Rogers, Richard B.; US2008/108667; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 116026-95-0 ,Some common heterocyclic compound, 116026-95-0, molecular formula is C11H14N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-oxo-1,2-Dihydro-[1,7]naphthyridine-3-carboxylic Acid Ethyl Ester (6-3) A solution of 6-2 (2.20 g, 9.90 mmol, 1 equiv), diethyl malonate (3.00 mL, 19.8 mmol, 2.00 equiv), and piperidine (0.490 mL, 4.95 mmol, 0.500 equiv) in ethanol (50 mL) was heated at reflux for 20 h. The reaction mixture was allowed to cool to 23 C., then concentrated to about half its volume. The white crystals which formed were filtered and washed with cold ethanol (20 mL) to give 2-oxo-1,2-dihydro-[1,7]naphthyridine-3-carboxylic acid ethyl ester (6-3). 1H NMR (400 MHz, CDCl3) delta 12.15 (br s, 1H), 8.94 (s, 1H), 8.52 (d, 1H, J=5.2 Hz), 8.46 (s, 1H), 7.52 (d, 1H, J=5.2 Hz), 4.48 (q, 2H, J=7.1 Hz), 1.46 (t, 3H, J=7.1 Hz); TLC (EtOAc), Rf=0.13.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,116026-95-0, its application will become more common.

Reference:
Patent; Merck & Co., Inc.; US6479512; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 20511-12-0 ,Some common heterocyclic compound, 20511-12-0, molecular formula is C5H5IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 5-iodopyridin-2-amine(0.7 g, 3.18 mmol) in HBr [(1.26 g, 15.6 mmol (48% in water)] at 0 00 sodium nitrite (0.746 g, 10.82 mmol) in water was added drop wise, followed by addition of bromine (1 .71 g, 10.82 mmol). The reaction mixture was kept at room temperature for 1 h. The reaction mixture was quenched with NaOH solution and extracted with ethyl acetate, washed with water, and dried overanhydrous Na2SO4. The solvent was removed under vacuo. The crude product was purified by column chromatography to yield title compound (0.6 g, 65.23%) as a white solid. LCMS: (M+H) = 284; 1H NMR: (DMSO-d6, 300MHz) 6 8.64-8.65 (d, 1 H), 8.09- 8.12 (dd, 1H), 7.50-7.53 (m, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 20511-12-0, 5-Iodopyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; MADANAHALLI RANGANATH RAO, Jagannath; GURRAM RANGA, Madhavan; PACHIYAPPAN, Shanmugam; WO2014/202580; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 929617-30-1 ,Some common heterocyclic compound, 929617-30-1, molecular formula is C7H6BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Under nitrogen protection, to 6 mL of dioxane was added 5-bromo-3-methyl-lH- pyrazolo[3,4-c]pyridine from Example 102 (0.21 g, 1 mmol), 3-fluorophenylboronic acid (0.28 g, 2 mmol), PdCl2(dppf) (87 mg, 0.1 mmol) and 2 M Na2C03 (2 mmol, 1 mL). The suspension was heated under microwave radiation at 130 C for 1 hour. It was cooled to room temperature and the solvent was removed the solvent. The crude product was purified by SGC(EtO Ac/Petroleum : 1/1) to afford 79 mg (34%) of 122 as a white solid. 1H NMR (400MHz,CDCl3): delta 9.12 (s, 1 H), 7.98 (s, 1 H), 7.75 – 7.82 (m, 2 H), 7.44 – 7.47 (m, 1 H), 7.08 – 7.09 (m, 1 H), 2.67 (s, 3 H). ESI MS m/z = 229 (M+l)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,929617-30-1, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; DO, Steven; HU, Huiyong; KOLESNIKOV, Aleksandr; LEE, Wendy; TSUI, Vickie Hsiao-Wei; WANG, Xiaojing; WEN, Zhaoyang; WO2013/24002; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1000341-55-8 ,Some common heterocyclic compound, 1000341-55-8, molecular formula is C7H4ClIN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

a) Preparation of intermediate 10A stirred solution of 6-chloro-3-iodo-5-azaindole (1.00 g, 3.56 mmol) in DMF (35 ml) at 0 C, was treated with sodium hydride (60%> in mineral oil, 0.17 g, 4.31 mmol). After stirring at 0 C for 10 minutes, the mixture was treated with p-toluenesulfonyl chloride (0.75 g, 3.95 mmol), then warmed to ambient temperature over 30 minutes. The reaction was quenched by the addition of water, then partitioned between EtOAc and dilute aqueous sodium bicarbonate solution. The organic phase was washed with brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography on silica gel, eluting with a mixture of EtOAc and cyclohexane (0: 1 to 6:4 by volume), to afford the desired product as a white solid (1.18 g, 76%).LCMS (Method B): Rt= 4.19 min, m/z [M+H]+= 433/435

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1000341-55-8, 6-Chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; HYND, George; TISSELLI, Patrizia; CLARK, David, Edward; KULAGOWSKI, Janusz, Jozef; MACLEOD, Calum; MANN, Samuel, Edward; PANCHAL, Terry, Aaron; PRICE, Stephen, Colin; MONTANA, John, Gary; WO2015/44267; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 170235-18-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 170235-18-4 as follows.

(1) 3-(trifluoromethyl) phenol (1.317 g, 0.0081 mol) was dissolved in 10 ml of dried dimethyl acetamide. While cooling the obtained solution with water, sodium hydride (0.39 g (ca. 60% in mineral oil), 0.0081*1.2 mol) was added to the solution. After completion of the foaming, a solution obtained by dissolving 6-bromo-5-methoxy-2-pyridine carboxylic acid methyl ester (2.0 g, 0.0081 mol) in 10 ml of dried dimethyl acetamide, and then copper iodide (1.55 g, 0.081 mol) were successively added to the solution. The obtained mixture was heated and stirred at 120 C. for 10 hours. Thereafter, the obtained reaction solution was cooled, mixed with 50 ml of water and then with 50 ml of ethyl acetate, and filtered through a glass filter provided with Hyflo Super-Cell. The obtained filtrate was extracted with ethyl acetate to obtain an aimed product. An organic phase was separated from the product, washed with water and then dried with anhydrous sodium sulfate. The dried product was concentrated, and the obtained residues were purified by silica gel column chromatography (eluding solution: ethyl acetate/hexane). Yield weight: 0.68 g; yield percentage: 26%; solid; melting point: 116 to 118 C.; 1 H-NMR (60 MHz, CDCl3, delta): 3.76(3H, s), 3.86(3H, s), 7.16(1H, d, J=8 Hz), 7.2-7.5(4H, complex), 7.80(1H, d, J=8 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,170235-18-4, its application will become more common.

Reference:
Patent; Kureha Kagaku Kogyo Kabushiki Kaisha; US6159901; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 83664-33-9, name is 2-(Benzyloxy)-5-bromopyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-(Benzyloxy)-5-bromopyridine

To a solution of [2-BENZYLOXY-5-BROMO-PYRIDINE] (1.64 g, 6.2 mmol) in tetrahydrofuran (25 [ML,-78C)] was added n-butyllithium (2.5 M in hexane, 2.61 mL, 1.05 equiv). After 1 h [AT-78C,] dimethylformamide (0.97 mL, 2 equiv) was added and the mixture stirred for 30 min. The reaction was quickly poured into a stirred solution of 5% aqueous sodium bicarbonate (50 [ML)] and extracted with diethyl ether [(-3X).-THE ETHEREAL-WAS WASHED-WITH BRINE, DNeD-OVER MaGNESIUM~SULFATE, AND] concentrated to give 1.16 g (quant. ) which was used without purification. Mass spec.: 186.34 [(MH)] [+.]

With the rapid development of chemical substances, we look forward to future research findings about 83664-33-9.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/104236; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem