Tag: M.W=300-400

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 571189-16-7, name is tert-Butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate, the common compound, a new synthetic route is introduced below. Formula: C14H20N4O4

To 4-(6-nitro-pyridin-3-yl)-piperazine-1 -carboxylic acid tert- butyl ester (2.0 g, 6.43 mmol) in EtOH (15 ml.) is added Pd/C (200 mg) under a hydrogen atmosphere maintained by a H2 balloon for 3h. The reaction mixture is filtered and the filtrate is concentrated under reduced pressure to afford the crude title compound. (0489) Yield: 1.90 g (quantitative)

The synthetic route of 571189-16-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HYDRA BIOSCIENCES, INC.; BRUNETTE, Steven; CUI, Jianwen; LOWE, Michael D.; SARKO, Christopher Ronald; SURPRENANT, Simon; TURNER, Michael Robert; WU, Xinyuan; SMITH KEENAN, Lana Louise; BOUYSSOU, Thierry; (183 pag.)WO2019/158572; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1061357-87-6, 6-Bromo-4-iodonicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1061357-87-6, blongs to pyridine-derivatives compound. Recommanded Product: 1061357-87-6

To a solution of intermediate 27A (060 g, 1.94 mmol) in a mixture of toluene (10 mL) and water (2 mL) was added cyclopropylboronic acid (0.20 g, 2.33 mmoi) followed by K3P04 (0.82 g. 3.88 mmol) and the resulting mixture was degassed for 15 minutes, Palladium(I1) acetate (0.05 g, 0.19 mmol) and tricyclohexylphosphine (0.11 g, 0.39 rnrnol) ware added. The resultingmixture was degassed again for 10 minutes and heated at 140 C for I h in the microwave. The reaction mixture was cooled to ambient temperature and filtered through Celite. The filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (Redisep-J2 g, 15-20% EtOAc/n-Hexanes) to obtain Intermediate 27 (010 g, 2308%) as a yellow solid. ?H NMR (400 MHz, DMSO-d6) ppm 0.93 1.02 (rn, I H), 1.04 1.13 (m. 1 H), 1.19 1.35 (m, 2 H), 2.05 221 (rn, I H), 851 (s, I H), 8.75 (s, I H). LCMS Method-D):retention time 2.25 mi [M4-2H1 223.0.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1061357-87-6, 6-Bromo-4-iodonicotinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GUNAGA, Prashantha; BHIDE, Rajeev S.; BORA, Rajesh Onkardas; PANDA, Manoranjan; YADAV, Navnath Dnyanoba; PRIESTLEY, Eldon Scott; RICHTER, Jeremy; (321 pag.)WO2018/93569; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1334411-79-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1334411-79-8, name is 4-Bromo-2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridine, molecular formula is C12H6BrCl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 4-bromo-2-(2,6-dichlorophenyl)-3H-imidazo[4,5-c]pyridine (400 mg, 1.166mmol)andcyclopropanecarboxamide(198 mg, 2.33mmol), Pd2dba3(53 mg, 0.0583mmol),XantPhos(67 mg, 0.117mmol) and Cs2CO3(1.14 g, 3.5mmol) in 1,4-dioxanes (5 mL)and 1,2-dimethoxyethane (5 mL) was heated in a microwave at 150C for 10 min. The reaction mixture was cooled and filtered, and the filter cake was washed withdichloromethane. The combined organics were washed with brine, dried over MgSO4and concentrated. The crude product was purified by reverse phase HPLC to give the title compound (321 mg, 79% yield) as a white solid.1H NMR (500 MHz, DMSO-d6) delta 12.25 (s, 1H), 10.99 (s, 1H), 8.10 (d,J= 5.6 Hz, 1H), 7.63 (q,J= 6.8 Hz, 4H), 7.56 – 7.35 (m, 1H), 2.07 (s, 0H), 0.89 (d, J = 33.0 Hz, 4H). HRMS m/z [M+H]+calcd.forC16H12Cl2N4O 347.0466, found 347.0458.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1334411-79-8, 4-Bromo-2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridine.

Reference:
Article; Liang, Jun; Van Abbema, Anne; Balazs, Mercedesz; Barrett, Kathy; Berezhkovsky, Leo; Blair, Wade S.; Chang, Christine; Delarosa, Donnie; DeVoss, Jason; Driscoll, Jim; Eigenbrot, Charles; Goodacre, Simon; Ghilardi, Nico; MacLeod, Calum; Johnson, Adam; Bir Kohli, Pawan; Lai, Yingjie; Lin, Zhonghua; Mantik, Priscilla; Menghrajani, Kapil; Nguyen, Hieu; Peng, Ivan; Sambrone, Amy; Shia, Steven; Smith, Jan; Sohn, Sue; Tsui, Vickie; Ultsch, Mark; Williams, Karen; Wu, Lawren C.; Yang, Wenqian; Zhang, Birong; Magnuson, Steven; Bioorganic and Medicinal Chemistry Letters; vol. 27; 18; (2017); p. 4370 – 4376;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 757978-18-0, 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 757978-18-0, blongs to pyridine-derivatives compound. Application In Synthesis of 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine

100 mL round bottom flaskIodo-1H-pyrrole [2,3-b] pyridine (M1) (100.0 mg, 3.1 mmol)20 mL of dichloromethane, triethylamine (930 mg, 9.2 mmol), DMAP (40 mg, 0.31 mmol),Benzenesulfonyl chloride (N1) (1100 mg, 6.2 mmol) was dissolved in 10 mL of dichloromethane under ice-cooling,Dropping funnel through the constant pressure drop into the solution, the drop is completed, stirring at room temperature 1h,TLC detection, no M1 remaining, washed 3 times, liquid separation, the organic phase anhydrous sodium sulfate drying,The solvent was removed by concentration and recrystallized from ethyl acetate (5 mL) to give a white solid which was dried to give 5-bromo-3-iodo-1- (phenylsulfonyl) -1H-pyrrole [2,3-b] pyridine (B8).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,757978-18-0, its application will become more common.

Reference:
Patent; Fudan University; Zhou, Yaming; Yang, Chengbin; Hong, Hui; Liu, Xiaofeng; Yang, Yongtai; Ling, Yun; Gu, Yu; Deng, Mingli; (38 pag.)CN106117181; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 757978-18-0, 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H4BrIN2, blongs to pyridine-derivatives compound. Computed Properties of C7H4BrIN2

To a 500 ml 3-neck flask, 5-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine (32 g, 99.1 mmol) and DMF (300 ml) were added. The solution was cooled to -40 C. under nitrogen and sodium hydride (2.8 g, 118.9 mmol) was added in 2 batches. The mixture was stirred at -40 C. for 1 hour. Then SEM-Cl (21 ml, 118.9 mmol) in DMF (50 ml) was added drop wise and the resulting mixture was allowed to stir at -40 C. for another 2 hours. The reaction was quenched with saturated NH4Cl (40 ml) and worked up with ethyl acetate, brine, dried with Na2SO4, concentrated to dryness. Silica chromatography of the crude using a gradient of ethyl acetate and hexane afforded 5-bromo-3-iodo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridine (32.8 g, 73% yield). NMR (500 MHz, DMSO-d6) delta 0.06 (s, 9H), 0.91 (m, 2H), 3.62 (m, 2H), 5.70 (s, 2H), 8.04 (m, 1H), 8.11 (s, 1H), 8.51 (m, 1H). MS: m/z 455.9 (M+H+).

The synthetic route of 757978-18-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SGX Pharmaceuticals, Inc.; US2008/261921; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 53710-17-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.53710-17-1, name is 2,6-Diiodopyridine, molecular formula is C5H3I2N, molecular weight is 330.89, as common compound, the synthetic route is as follows.

To a solution of 25 mmol of 20 in 80 mL of dry THF at 0 C was added 25 mmol of KH (30% mineral oil) under N2. The suspension was stirred for 20 min before 10 mmol of 15 in 20 mL of dry THF was added over a period of 10 min. The resulting mixture was stirred for two days at 60 C under N2. The reaction was quenched dropwise with isopropanol (10 mL) and saturated NaCI (50 mL) at 0 C and the mixture was diluted with 200 mL of ethyl acetate. After separating the two phases, the organic phase was washed with saturated NaCl, dried over MgS04, and concentrated under reduced pressure to give 10 mmol of 21. ¹H NMR (300 MHz, DMSO-d6) 8 8.92 (d, J = 2.1 Hz, 2H), 8.11 (t, J = 7.8 Hz, 1H), 7.84 (d, J = 0.9 Hz, 2H), 7.79 (d, J = 8.0 Hz, 2H), 6.61 (dd, J1 = 2.8 Hz, J2 = 0.9 Hz, 2H) ; MS m/z: 212 (M + 1).

Statistics shows that 53710-17-1 is playing an increasingly important role. we look forward to future research findings about 2,6-Diiodopyridine.

Reference:
Patent; ICAGEN, INC.; ASTELLAS PHARMA INC.; WO2005/100349; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 117977-21-6, Name is 2-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole, SMILES is COCCCOC1=C(C(=NC=C1)CSC2=NC3=C([NH]2)C=CC=C3)C, belongs to pyridine-derivatives compound. In a document, author is Bhoi, Manoj N., introduce the new discover, Name: 2-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole.

Novel benzothiazole containing 4H-pyrimido[2,1-b]benzothiazoles derivatives: One pot, solvent-free microwave assisted synthesis and their biological evaluation

Synthesis of new and desired compounds has an everlasting demand. The present work emphasizes on the one pot, three component microwave assisted synthesis of novel ethyl 2-methyl-4-(pyridin-2-yl)-4H-benzo[4,5]thiazolo[3,2-a]pyrimidine-3-carboxylate derivatives by the reaction of 2-aminobenzothiazole derivatives with Pyridine 2-aldehyde and Ethyl acetoacetate in the presence of PdCl2 as an expeditious catalyst under solvent-free condition. The salient features of this approach are operational simplicity, convergence, short reaction time, high atom economy, easy workup, mild reaction conditions and environmentally benign conditions. All the newly synthesized diverse poly-functionalized tri-heterocyclic benzothiazole derivatives have been characterized by elemental analysis and various spectroscopic methods such as FT-IR, H-1 NMR, C-13 NMR, ESI-MS and Single crystal X-ray analysis (4a). All the final scaffolds have been screened for antibacterial and antioxidant activities. Also their antitubercular activity against Mycobacterium tuberculosis H37RV was screened. (C) 2016 The Authors. Published by Elsevier B.V. on behalf of King Saud University.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 117977-21-6 is helpful to your research. Name: 2-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 150322-38-6, Name is 5-(2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one, formurla is C18H18FNO2S. In a document, author is Mahmoudi, Ghodrat, introducing its new discovery. HPLC of Formula: https://www.ambeed.com/products/150322-38-6.html.

Ligand structure-driven self-assembly of Zn(NCS)(2) with a carbohydrazone ligand: A possible intermediate towards a [2 x2] metallic grid

In this work we have synthesized and characterized a new trinuclear heteroleptic discrete zin.(II) complex [Zn-3(HL)(2) (NCS)(4)], fabricated from a mixture of Zn(NO3)(2) and NaNCS with a symmetric and bulky carbohydrazone derived from carbohydrazide and benzoyl pyridine (H2L). The global structure and shape of complex are dictated by two monodeprotonated ligands HL – each coordinating the same Zn(II) ion through one of the pendant arms in an orthogonal fashion, yielding a distorted octahedral N4O2 coordination environment. The second coordination pocket of both ligands each traps Zn(NCS)(2) species, yielding an N4O coordination environment. The hexa- and pentacoordinated metals are separated by about 4 angstrom and positioned almost at a right angle (similar to 87 degrees) addressed by the orientation of organic ligands. The structure of [Zn-3 (HL)(2) (NCS)(4)] is mimicking grid-like structures and can be considered as a possible intermediate towards a [2 x2] metallic grid. The thiocyanate anions block two of three metal sites that could potentially serve as coordination nodes to fulfil the grid formation. A pair of molecules, arranged about an inversion center, are linked through a pair of (N)C-S center dot center dot center dot pi(Py) noncovalent interactions, which have been rationalized using density functional theory (DFT) calculations, and characterized using the noncovalent interaction plot (NCIplot) index and molecular electrostatic potential (MEP) surface computational tools. (C) 2020 Elsevier B.V. All rights reserved.

If you are hungry for even more, make sure to check my other article about 150322-38-6, HPLC of Formula: https://www.ambeed.com/products/150322-38-6.html.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 144750-42-5, Name is (S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride, formurla is C15H15Cl2NO2S. In a document, author is Ma, Ning, introducing its new discovery. COA of Formula: https://www.ambeed.com/products/144750-42-5.html.

New Insight into Charge-Transfer Enhancement for SERS in Cosputtering (Ag)(x)(ZnS)(y) System: The Carrier Density Effect

Cosputtering technology was utilized to combine Ag with ZnS at different doping contents into a new material, which was referred to as the (Ag)(x)(ZnS)(y) (x = 10 W, y = 20, 40, 60, 80, 100 W) system. The carrier density is characterized through the Hall effect, and the change in the bandgap distribution due to the change in carrier density is calculated by ultraviolet photoelectron spectroscopy (UPS). By increasing the sputtering power of the ZnS in the (Ag)(x)(ZnS)(y) system, the carrier density and the conduction band (CB)/valence band (VB) were decreased. Interestingly, we found a liner relationship between the surface-enhanced Raman scattering (SERS) intensity ratio of b(2) to a(1) bands and the carrier density, which intuitively expresses that I-b2/I-a1 increases as the carrier density decreases. The development of the carrier density regulation of SERS materials can be used to monitor the possible CT enhancement for SERS.

If you are hungry for even more, make sure to check my other article about 144750-42-5, COA of Formula: https://www.ambeed.com/products/144750-42-5.html.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Safety of 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 503615-03-0, Name is 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one, molecular formula is C15H17N3O4. In an article, author is Guthardt, Robin,once mentioned of 503615-03-0.

N-heterocyclic olefins as dative carbon donor ligands for diaminoplumbylenes: Syntheses and crystal structures of adducts with 1,3,4,5-tetramethyl-2-methyleneimidazoline

The aim of this study was to shed more light on the potential of N-heterocyclic olefins as carbon donor ligands for the coordination/stabilization of divalent Group 14 element compounds. Stable adducts of the N-heterocyclic olefin 1,3,4,5-tetramethyl-2-methyleneimidazoline (MeIMeCH2) were isolated with the cyclic diaminoplumbylenes ph(NSiMe3)(2)Pb (ph = 1,2-phenylene) and fc(NSiRMe2)(2)Pb (fc = 1,10-ferrocenylene; R = Me, tBu) as well as with the acyclic congener [(Me3Si)(2)N](2)Pb. In contrast, the cyclic (alkyl)(amino)carbene 1-(2,6-diisopropylphenyl)-3,3-diethyl-5,5-dimethylpyrrolidin-2-ylidene (CAAC(Et)) gave rise to a stable adduct only with ph(NSiMe3)(2)Pb. The ferrocene-based N-heterocyclic olefin fc (NCH(2)tBu)(2)CCH2 was synthesised. It afforded a stable adduct with triphenylborane, but not with the diaminoplumbylenes of this study. All stable adducts were structurally characterized by single-crystal X-ray diffraction. An essentially perpendicular orientation of the Pb-C bond vector with respect to the PbN2 plane was found for the diaminoplumbylene adducts. Pb-207 NMR spectroscopic data suggest, but do not prove, that the strength of the donor-acceptor interaction of the (IMeCH2)-I-Me adducts is lower than that of adducts with the related N-heterocyclic carbene 1,3,4,5-tetramethylimidazolin-2-ylidene, but higher than that of adducts with the popular N-donor 4-(dimethylamino)pyridine. (C) 2020 Elsevier Ltd. All rights reserved.

If you’re interested in learning more about 503615-03-0. The above is the message from the blog manager. Safety of 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem