Tag: M.W=300-400

In an article, author is Lin, Lixia, once mentioned the application of 145100-51-2, Recommanded Product: 2-[N,N-Bis(Trifluoromethylsulphonyl)amino]-5-chloropyridine, Name is 2-[N,N-Bis(Trifluoromethylsulphonyl)amino]-5-chloropyridine, molecular formula is C7H3ClF6N2O4S2, molecular weight is 392.6831, MDL number is MFCD00191833, category is pyridine-derivatives. Now introduce a scientific discovery about this category.

A Ce(iii) complex potently inhibits the activity and expression of tyrosine phosphatase SHP-2

Four new Ce(iii) complexes 1-4 with tridentate NNO-donor Schiff base ligands have been designed and successfully synthesized. These complexes were characterized by elemental analysis, IR, and ESI-MS, with formulas of [Ce(HL1)(2)(NO3)(3)]2CH(3)OH (1), [Ce(L2)(2)(NO3)]3H(2)O (2), [Ce(HL3)(L3)(NO3)Br]H2O (3) and [Ce(L4)(2)(NO3)]3H(2)O (4), in which ligands HL1-HL4 are respectively N ‘-[(1E)-pyridin-2-ylmethylidene]pyrazine-2-carbohydrazide (HL1), 2-(1-(salicyloylhydrazono)ethyl)pyrazine (HL2), N ‘-[(1E)-pyridin-2-ylmethylidene]pyridine-2-carbohydrazide (HL3) and 2-(1-(salicyloylhydrazono)ethyl) pyridine (HL4). X-ray single crystal diffraction analysis indicates that complex 1 crystallizes in the monoclinic system with the space group C-2/c and the structure of complex 1 consists of a monomeric Ce(iii) species with a Ce(iii) moiety bonded to two tridentate Schiff base ligands, three nitrates and solvents. These complexes effectively inhibit the enzyme activities of PTPs (SHP-1, SHP-2, TCPTP and PTP1B), among which complex 3 shows the most potent inhibition of SHP-2 with the lowest IC50 value of 0.61 mu M and displays obvious selectivity towards SHP-2. Its inhibition potency against SHP-2 was approximately 17, 4, and 5 fold higher than that against SHP-1, TCPTP and PTP1B, respectively. Further study discloses that complex 3 inhibits SHP-2 in a competitive manner. Fluorescence measurements indicate that complex 3 tightly binds to SHP-2 with a molar ratio of 1:1 and a binding constant of 5.45 x 10(5) M-1. Western blot experiments show that complex 3 promotes the phosphorylation of the SHP-2 substrate by the combination of the inhibition of the activity and expression of SHP-2. Moreover, complex 3 decreases the survival rate of A549 cells to 35.12% at 100 mu M and induces apoptosis with an apoptosis rate of 12.06% at 50 mu M. All these results suggest that complex 3 is a potential bi-functional inhibitor of the activity and expression of tyrosine phosphatase SHP-2.

If you are interested in 145100-51-2, you can contact me at any time and look forward to more communication. Recommanded Product: 2-[N,N-Bis(Trifluoromethylsulphonyl)amino]-5-chloropyridine.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 325855-74-1, Name is 5-Chloro-6′-methyl-3-(4-(methylsulfonyl)phenyl)-[2,3′-bipyridine] 1′-oxide, SMILES is O=S(C1=CC=C(C2=CC(Cl)=CN=C2C3=C[N+]([O-])=C(C)C=C3)C=C1)(C)=O, belongs to pyridine-derivatives compound. In a document, author is Cinarli, Murat, introduce the new discover, Recommanded Product: 325855-74-1.

Synthesis, structural characterization, Hirshfeld surface analysis, antimicrobial activity, and DNA cleavage studies of (Z)-4-methyl-N ‘-(phenyl(pyridin-2-yl)methylene)benzenesulfonohydrazide and its Co(II), Ni(II) and Zn(II) complexes

The NNO tridentate Schiff base ligand of 2-benzoyl pyridine sulfonyl hydrazone (HL) and its transition metal complexes [CoL2] (1), [NiL2] (2) and [ZnL2] (3) have been synthesized and characterized by analytical and spectroscopic studies. The molecular structures of HL and [NiL2] (2) have been investigated by X-ray diffraction and DET/B3LYP methods. Based on the optimized structures, a single point energy calculation was made for HL and (2) in the different solvent media. The stability of the molecular structures was investigated in different solvent environments by calculating the molecular orbital energies and total energies of the molecular structures. The global reactivity parameters were obtained and the interactions between the molecules with DNA bases such as adenine, cytosine, guanine, and thymine were investigated by using the ECT (electrophilicity-based charge transfer) method and Delta N (charge transfer). Hirshfeld surfaces of HL and (2) complex were investigated and the interaction energies between the molecules participating in C-H center dot center dot center dot O/pi interactions in the molecular structures were calculated by using the CE-HF energy model. From elemental analysis data, the metal-ligand ratio of the complexes was found to be 1:2. All compounds were examined for their antimicrobial activity against pathogenic microorganisms by the well-diffusion method. DNA cleavage studies of compounds were screened by the agarose gel electrophoresis method. The results showed that complex (3) showed highly nicking activity, while HL, (1) and (2) complexes didn’t show any nicking activity. (C) 2019 Elsevier B.V. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 325855-74-1 is helpful to your research. Recommanded Product: 325855-74-1.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Reference of 103577-40-8, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 103577-40-8, Name is 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole, SMILES is FC(F)(F)COC1=C(C)C(CSC2=NC3=CC=CC=C3N2)=NC=C1, belongs to pyridine-derivatives compound. In a article, author is Arici, Hatice, introduce new discover of the category.

The synthesis of new PEPPSI-type N-heterocyclic carbene (NHC)-Pd(II) complexes bearing long alkyl chain as precursors for the synthesis of NHC-stabilized Pd(0) nanoparticles and their catalytic applications

Six new N-heterocyclic carbene (NHC) ligands bearing long-chain alkyl groups on N-atom of 5,6-dimethylbenzimidazole skeleton and their Pd(II) complexes (PEPPSI type) with a close formula of trans-[PdX2(NHC)Py] (X = Cl or Br; Py = pyridine) were successfully synthesized. The yielded NHC ligands and their Pd(II) complexes were characterized by elemental analysis, H-1- and C-13 NMR, FT-IR spectroscopy, and mass spectroscopy and the molecular structure of 3f was determined by X-ray crystallography. All synthesized NHC-Pd(II) complexes were air-stable both as powder and in solution under ambient conditions, which allow us to test them as catalysts in Suzuki-Miyaura cross-coupling (SMC) reactions and to use them as precursors for the in situ synthesis of NHC-stabilized Pd(0) nanoparticles (NPs) during the dehydrogenation of ammonia borane (AB) in dry tetrahydrofuran solution at room temperature. In this protocol, AB served both as a reducing agent for the reduction of NHC-Pd(II) complexes to yield NHC-stabilized Pd(0) NPs and a chemical hydrogen storage material for the concomitant hydrogen generation. The in situ synthesized NHC-stabilized Pd(0) NPs were characterized by UV-Vis spectroscopy, TEM, and XRD techniques. The catalytic activity of the in situ generated NHC-stabilized Pd(0) NPs in the dehydrogenation of AB was followed by measuring the volume of hydrogen generated versus time at room temperature. Among the five different NHC-Pd(II) complexes, 3c (dichloro[1-octadesyl3-(2,4,6-trimethylbenzyl)-(5,6-dimethylbenzimidazol-2-ylidene)](pyridine)palladium(II)) yielded the most stable Pd(0) NPs along with the highest catalytic activity in the dehydrogenation of AB (TOF= 37.7 min(-1) at 1 eqv. H-2 release). The B-11-NMR analysis of the THF solution after the catalytic dehydrogenation of AB revealed the formation of cyclopolyborazane, which is one of the important dehydrocoupling products of AB. Additionally, all NHC-Pd(II) complexes provided high yields in the SMC reactions of phenylboronic acid with various aryl bromides bearing electron-withdrawing or electron-donating groups and even for aryl chlorides bearing electron-withdrawing group at room temperature with the low catalyst loadings. This study revealed that the length of the alkyl chain of NHC ligands has a significant effect on the catalytic activity of the NHC-Pd(II) complexes in the SMC reactions, the longer the alkyl chain on the N atom of NHC ligand, the higher activity of NHC-Pd(II) complex in SMC reactions. It also influences the particle size, morphology and catalytic activity of in situ generated Pd(0) NPs in the dehydrogenation of AB. (C) 2020 Elsevier B.V. All rights reserved.

Reference of 103577-40-8, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 103577-40-8 is helpful to your research.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 150322-38-6, Name is 5-(2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one, molecular formula is C18H18FNO2S. In an article, author is Kusy, Damian,once mentioned of 150322-38-6, COA of Formula: C18H18FNO2S.

Synthesis of the 6-Substituted Imidazo[1,2-a]Pyridine-3-yl-2-Phosphonopropionic Acids as Potential Inhibitors of Rab Geranylgeranyl Transferase

Twelve phosphonopropionates derived from 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid (3-IPEHPC) were synthesized and evaluated for their activity as inhibitors of protein geranylgeranylation. The nature of the substituent in the C6 position of imidazo[1,2-a]pyridine ring was responsible for the compound’s activity against Rab geranylgeranyl transferase (RGGT). The most active inhibitors disrupted Rab11A prenylation in the human cervical carcinoma HeLa cell line. The esterification of carboxylic acid in the phosphonopropionate moiety turned the inhibitor into an inactive analog.

If you’re interested in learning more about 150322-38-6. The above is the message from the blog manager. COA of Formula: C18H18FNO2S.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Reference of 145100-51-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 145100-51-2, Name is 2-[N,N-Bis(Trifluoromethylsulphonyl)amino]-5-chloropyridine, SMILES is ClC1=CN=C(N(S(=O)(C(F)(F)F)=O)S(=O)(C(F)(F)F)=O)C=C1, belongs to pyridine-derivatives compound. In a article, author is Chu, Chiheng, introduce new discover of the category.

Cobalt Single Atoms on Tetrapyridomacrocyclic Support for Efficient Peroxymonosulfate Activation

Transition-metal catalysts that can efficiently activate peroxide bonds have been extensively pursued for various applications including environmental remediation, chemical synthesis, and sensing. Here, we present pyridine-coordinated Co single atoms embedded in a polyaromatic macrostructure as a highly efficient peroxide-activation catalyst. The efficient catalytic production of reactive radicals through peroxymonosulfate activation was demonstrated by the rapid removal of model aqueous pollutants of environmental and public health concerns such as bisphenol A, without pH limitation and Co2+ leaching. The turnover frequency of the newly synthesized Co single-atom catalyst bound to tetrapyridomacrocyclic ligands was found to be 2 to 4 orders of magnitude greater than that of benchmark homogeneous (Co2+) and nanoparticulate (Co3O4) catalysts. Experimental results and density functional theory simulation suggest that the abundant Tr-conjugation in the polyaromatic support and strong metal-support electronic interaction allow the catalysts to effectively adsorb and activate the peroxide precursor. We further loaded the catalysts onto a widely used poly(vinylidene fluoride) microfiltration membrane and demonstrated that the model pollutants were oxidatively removed as they simply passed through the filter, suggesting the promise of utilizing this novel catalyst for realistic applications.

Reference of 145100-51-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 145100-51-2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Mokhtari, Tayebeh Sattaei, once mentioned the application of 503615-03-0, Name is 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one, molecular formula is C15H17N3O4, molecular weight is 303.31, MDL number is MFCD19440872, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Computed Properties of C15H17N3O4.

Polar [3+2] cycloaddition of isatin-3-imines with electrophilically activated heteroaromatic N-ylides: Synthesis of spirocyclic imidazo[1,2-a]pyridine and isoquinoline derivatives

A new synthesis of spiro[imidazo[1,2-a]pyridine-2,3′-indoline]-2′-ones 3a-f and spiro[imidazo[1,2-a]isoquinoline-2,3′-indolin]-2′-ones 5a-d, respectively by polar [3 + 2] cycloaddition reactions of isatin-3-imines with pyridinium and isoquinolinium ylides which are derived from 2-bromoacetophenone, 2,4′-dibromoacetophenone or methyl bromoacetate is described. These cycloaddition reactions consist of the nucleophilic attack of the heteroaromatic N-ylides on isatin-3-imine derivatives. The salient features of these processes include operational simplicity, high yields, and easily accessible starting materials. In addition, Density Functional Theory (DFT) calculations at the M06-2X/6-31 + G(d) level have been performed to investigate the possible transition states and products. The theoretical results are in good agreement with the experimental findings and show that the product 3a is the most stable product and is formed through a kinetically feasible pathway. (C) 2015 The Authors. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 503615-03-0, Computed Properties of C15H17N3O4.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.877399-00-3, Name is (R)-5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine, SMILES is NC1=NC=C(Br)C=C1O[C@@H](C2=C(Cl)C=CC(F)=C2Cl)C, belongs to pyridine-derivatives compound. In a document, author is Mo, Zhousheng, introduce the new discover, Product Details of 877399-00-3.

Effect of Content of Cerium Ion on Bronsted-Acid-Catalyzed Reaction of Thiophene over CeY Zeolite Studied by In Situ FTIR Spectroscopy

With NaY zeolite as the raw material, CeY zeolites with different content of Ce ions were prepared by liquid phase ion exchange (LPIE) method. Their chemical compositions were measured by X-ray fluorescence spectrometry (XRF) and in situ Fourier transform infrared spectroscopy (FTIR) techniques. Temperature-programmed desorption of ammonia (NH3-TPD) and FTIR spectra of pyridine (Py-FTIR) techniques were used to characterize acidity of CeY zeolites. With thiophene (TP, C4H4S) as probe molecule, adsorption and reaction of TP over CeY zeolites were researched by using in situ FTIR spectroscopy. Finally, it can be found that activity of Bronsted(B)-acid-catalyzed reaction of TP firstly increases and then has little change with the increase of concentration of Ce(NO3)(3) solution (c), while increases with the increase of the exchange times by a combination of adsorption and reaction of TP over CeY zeolite with acidity of CeY zeolite and with location of Ce ion in CeY zeolite. Especially, the sulfur-metal (S-M) interaction between TP and Ce ion located in the supercage exhibits more influence than B-acid-catalyzed reaction of TP on adsorption desulfurization of CeY zeolite.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 877399-00-3. Product Details of 877399-00-3.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 150322-38-6, Name is 5-(2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one, molecular formula is C18H18FNO2S, belongs to pyridine-derivatives compound. In a document, author is Reddy, Raju Jannapu, introduce the new discover, Safety of 5-(2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one.

An Efficient Sequential One-Pot Approach for the Synthesis of C3-Functionalized Imidazo[1,2-a]pyridines under Transition-Metal Free Conditions

A metal-free sequential one-pot three-component protocol is described for the synthesis of C3-functionalized imidazo[1,2-a]pyridines. A successive construction of imidazo[1,2-a]pyridine followed by iodine-catalysed sulfenylation has been achieved in a one-pot operation from readily available alpha-bromomethyl ketones, 2-aminopyridines and thiosulfonates. An immense array of 3-sulfenylimidazo[1,2-a]pyridines were obtained in good to high yields. Also, the method extended for the synthesis of C3-halogenated imidazo[1,2-a]pyridines using sodium halides in the presence of K2S2O8. Notably, the reaction between alpha-bromomethyl ketones and 2-aminopyridines in the presence of K2S2O8 to yield 3-bromo-2-aryl-imidazo[1,2-a]pyridines, thus implies alpha-bromomethyl ketones also served as brominating agent. Overall, the present sequential one-pot protocol is straightforward, operationally simple, tolerates a broad range of functional groups, and is reliable for gram-scale experiments.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 150322-38-6. Safety of 5-(2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 103577-40-8, Name is 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole, SMILES is FC(F)(F)COC1=C(C)C(CSC2=NC3=CC=CC=C3N2)=NC=C1, in an article , author is Porter, Jacob D., once mentioned of 103577-40-8, Quality Control of 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole.

An anthrone-based Kv7.2/7.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders

A set of novel Kv7.2/7.3 (KCNQ2/3) channel blockers was synthesized to address several liabilities of the known compounds XE991 (metabolic instability and CYP inhibition) and the clinical compound DMP 543 (acid instability, insolubility, and lipophilicity). Using the anthrone scaffold of the prior channel blockers, alternative heteroarylmethyl substituents were installed via enolate alkylation reactions. Incorporation of a pyridazine and a fluorinated pyridine gave an analog (compound 18, JDP-107) with a promising combination of potency (IC50=0.16 mu M in a Kv7.2 thallium flux assay), efficacy in a Kv7.2/7.3 patch clamp assay, and drug-like properties.

Interested yet? Read on for other articles about 103577-40-8, you can contact me at any time and look forward to more communication. Quality Control of 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In an article, author is Jin, Guo-Xia, once mentioned the application of 877399-00-3, Name is (R)-5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine, molecular formula is C13H10BrCl2FN2O, molecular weight is 380.04, MDL number is MFCD18207061, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Formula: C13H10BrCl2FN2O.

Three Ag-I, Cu-I and Cd-II coordination polymers based on the new asymmetrical ligand 2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole: syntheses, characterization and emission properties

The new asymmetrical organic ligand 2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5(pyridin-4-yl)-1,3,4-oxadiazole (L, C17H13N5O), containing pyridine and imidazole terminal groups, as well as potential oxdiazole coordination sites, was designed and synthesized. The coordination chemistry of L with soft AgI, CuI and CdII metal ions was investigated and three new coordination polymers (CPs), namely, catena-poly[[silver(I)-mu-2-{4-[(1H-imidazol-1-yl)methyl]phenyl}5-(pyridin-4-yl)-1,3,4-oxadiazole] hexafluoridophosphate], {[Ag(L)]PF6}n, catena-poly[[ copper(I)-di-mu-iodido-copper(I)-bis(mu-2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole)] 1,4-dioxane monosolvate], {[Cu2I2(L)(2)]mu C4H8O2}n, and catena-poly[[[dinitratocopper(II)]-bis(mu-2-{4-[(1Himidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole)]-methanol-water (1/1/0.65)], {[Cd(L)(2)(NO3)(2)]mu 2CH4O mu 0.65H2O}(n), were obtained. The experimental results show that ligand L coordinates easily with linear AgI, tetrahedral CuI and octahedral CdII metal atoms to form one-dimensional polymeric structures. The intermediate oxadiazole ring does not participate in the coordination interactions with the metal ions. In all three CPs, weak pi-pi interactions between the nearly coplanar pyridine, oxadiazole and benzene rings play an important role in the packing of the polymeric chains.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem