Design of Highly Enantioselective Organocatalysts Based on Molecular Recognition was written by Tang, Zhuo;Cun, Lin-Feng;Cui, Xin;Mi, Ai-Qiao;Jiang, Yao-Zhong;Gong, Liu-Zhu. And the article was included in Organic Letters in 2006.Quality Control of N-(6-Aminopyridin-2-yl)acetamide This article mentions the following:
Various organocatalysts have been designed based on mol. recognition to catalyze the asym. direct aldol reaction of ketones with aryl and alkyl α-keto acids, affording β-hydroxy carboxylic acids with a tertiary stereogenic center with excellent enantioselectivities of up to 98% ee. A linear effect was observed for the reaction, demonstrating a single mol. of the catalyst involved in the catalysis. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Quality Control of N-(6-Aminopyridin-2-yl)acetamide).
N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Quality Control of N-(6-Aminopyridin-2-yl)acetamide