Synthetic Route of 6635-86-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6635-86-5, name is 2-Amino-4-methyl-3-nitropyridine, molecular formula is C6H7N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 4-methyl-3-nitropyridin-2-amine (25 g, 163 mmol) in AcOH (250 ml) was added NaOAc (26.7 g, 326 mmol) and cooled to 15-20C. Bromine (78.24 g, 489 mmol) in AcOH (200 ml) was added over 30 min and stirred at room temperature for a period of 2 h. The reaction mixture was poured into ice water, the solid formed was filtered and dried to afford title compound as a yellow solid (32 g, 84 %); 1H NMR (400 MHz, DMSO-d6) delta 8.28 (s, 1H), 7.05 (s, 2H), 2.31 (s, 3H).
According to the analysis of related databases, 6635-86-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; BORUAH, Anima; CHITTY VENKATA, Srikanth; HOSAHALLI, Subramanya; PANIGRAHI, Sunil Kumar; WO2014/125408; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem