Adding a certain compound to certain chemical reactions, such as: 697739-13-2, Imidazo[1,5-a]pyridine-8-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of Imidazo[1,5-a]pyridine-8-carboxylic acid, blongs to pyridine-derivatives compound. Application In Synthesis of Imidazo[1,5-a]pyridine-8-carboxylic acid
To a solution of imidazo[1,5-a]pyridine-8-carboxylic acid (50 mg, 0.31 mmol) in DMF (5 mL) was added TEA (94 mg, 0.37 mmol), N,O-dimethylhydroxylamine hydrochloride (36 mg, 0.37 mmol) and HATU (140 mg, 0.37 mmol), the reaction was stirred at ambient temperature for about 2 hours. Concentrated under reduced pressure to remove solvent, to the residue was addedwater (5 mL). The mixture was extracted with CH2C12 (3* 10 mL), the combined organic phases were washed with sat.NaC1 (5 mL), dried over anhydrous Na2504, filtered, concentrated and purified by column chromatography on silica gel to give the product about 100 mg (> 95%, crude) as a pale yellow oil. MS (ESI) mle [M+1] 206.1.
The synthetic route of 697739-13-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BEIGENE, LTD.; WANG, Hexiang; ZHANG, Guoliang; GUO, Yunhang; REN, Bo; WANG, Zhiwei; ZHOU, Changyou; (219 pag.)WO2016/161960; (2016); A1;,
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