With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.903129-78-2, name is 6-Bromoimidazo[1,2-a]pyridine-8-carboxylic acid, molecular formula is C8H5BrN2O2, molecular weight is 241.04, as common compound, the synthetic route is as follows.HPLC of Formula: C8H5BrN2O2
The compound of example 23 (1 .0 g, 4.15 mmol) was treated with pyridin-3-ylboronic acid (0.510 g, 4.15 mmol) in the presence of [1 ,1 ‘-bis(diphenylphosphino)- ferrocene]dichloropalladium(ll) complex with dichloromethane (0.102 g, 0.124 mmol) and sodium carbonate(0.829 g, 8.30 mmol) according to the procedure for the preparation of the compound of example 2 to afford the title compound. Yield: 0.4 g (40.3 %); 1H NMR (DMSO-d6, 300 MHz): delta 7.54 (q, 1 H, J=4.8 Hz, Ar), 7.68-7.72 (m, 2H, Ar), 8.04 (s, 1H, Ar), 8.53-8.65 (m, 2H, Ar), 8.99 (d, 1H, J=1.8 Hz, Ar); 9.29 (d, 1H, J=1.8 Hz, Ar); MS (ES+): m/e 240 (M+1).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,903129-78-2, 6-Bromoimidazo[1,2-a]pyridine-8-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; SHARMA, Rajiv; GHOSH, Usha; MORE, Tulsidas; KULKARNI, Mahesh; BAJAJ, Komal; BURUDKAR, Sandeep; RIZVI, Zejah; WO2014/80241; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem