Adding a certain compound to certain chemical reactions, such as: 67625-38-1, Ethyl 6-chloroimidazo[1,2-a]pyridine-2-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: Ethyl 6-chloroimidazo[1,2-a]pyridine-2-carboxylate, blongs to pyridine-derivatives compound. name: Ethyl 6-chloroimidazo[1,2-a]pyridine-2-carboxylate
A solution of ethyl 6-chloroimidazo[l,2-a]pyridine-2-carboxylate (0.8 g, 3.6 mmol), cesium carbonate (1.3 g, 3.9 mmol), palladium acetate (64 mg, 0.29 mmol), andtriphenylphosphine (0.15 g, 0.57 mmol) in 1,4-dioxane (43 mL) was treated with l-bromo-3- fluorobenzene (0.54 mL, 4.8 mmol), degassed with nitrogen, and heated in the microwave at 150 C for 30 min. The reaction mixture was filtered over celite and the filtrate was concentrated to give a crude residue. This material was purified by flash column chromatography to give the desired product (1.2 g, 94%). LCMS for C16H13C1FN202 (M+H)+: m/z = 319.1.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,67625-38-1, Ethyl 6-chloroimidazo[1,2-a]pyridine-2-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; INCYTE CORPORATION; COMBS, Andrew P.; LI, Yun-Long; YUE, Eddy W.; SPARKS, Richard B.; WO2011/75643; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem