Reference of 1061357-89-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1061357-89-8 as follows.
A mixture of 2-bromo-5-fluoro-4-iodopyridine (6.8 g, 22.5 mmol), ethylene glycol (Sigma-Aldrich, St. Louis, MO, USA) (6.0 mL, 108.0 mmol), and potassium t-butoxide (Sigma-Aldrich, St. Louis, MO, USA ) (2.5 g, 22.7 mmol) in N-methylpyrrolidinone (10 mL) and THF (20 mL) was heated in a 60 oC bath. After 40 min, the mixture was removed from the oil bath and allowed to stir at RT for 14 h. The mixture was concentrated under reduced pressure. Additional potassium t-butoxide (0.5 g) and ethylene glycol (1.0 mL) were added and the reaction heated in an 80 oC bath for another 3 h then cooled to RT. ethyl acetate (200 mL) and water (150 mL) were added and the phases mixed and separated. The organic phase was washed with brine (75 mL) then evaporated to dryness under reduced pressure. Purification of the residue using silica gel chromatography (0 – 50% ethyl acetate in DCM) gave 2-((6-bromo-4-iodopyridin-3-yl)oxy)ethanol (3.1 g, 9.0 mmol, 40% yield). MS (ESI +ve ion) m/z: [M+1] = 343.8 / 345.8. 1H NMR (400 MHz, chloroFORM-d) _ 7.89 (s, 1H), 7.88 (s, 1H), 4.22 (td, J = 4.55, 6.36 Hz, 2H), 3.99-4.07 (m, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1061357-89-8, its application will become more common.
Reference:
Patent; AMGEN INC.; ALLEN, Jennifer R.; BOURBEAU, Matthew P.; BROWN, James A.; CHEN, Ning; FROHN, Michael J.; FU, Zice; LIU, Longbin; LIU, Qingyian; PETTUS, Liping H.; QIAN, Wenyuan; REEVES, Corey; SIEGMUND, Aaron C.; (362 pag.)WO2018/112094; (2018); A1;,
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