As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 199296-40-7, name is tert-Butyl (5-formylpyridin-2-yl)carbamate, molecular formula is C11H14N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 199296-40-7
100 g crude acrylic acid ester isomeric mixture prepared according to Example 3 was dissolved in 1 L HCl (5 N) and heated to reflux until complete conversion was achieved. The mixture was cooled to ambient temperature and the pH was adjusted to 7 with concentrated NaOH. The precipitate was filtered off and crystallized from boiling water to yield 25.2 g of 29 (E)-3-(6-Amino-pyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)-acrylic acid. [0288] 1H-NMR (600.2 MHz, CD4OD):=1.34 (m, 2H), 1.52 (m, 2H), 1.77 (m, 4H), 1.94 (m, 2H), 2.18 (m, 2H), 4.22 (dddd, J=1.52, 1.77, 7.42, 8.44, 1H), 6.51 (d, J=7.86 Hz, 1H), 7.19 (d, J=7.82 Hz, 1H), 7.41 (dd, J=4.22, 8.44 Hz, 1H), 7.82 (dd, J=7.19, 7.86 Hz, 1H), 7.86 (dd, J=7.19, 7.82 Hz, 1H), 8.44 (dd, J=4.22, 7.42 Hz, 1H). [0289] HPLC: tR=3.60 (Z) and 3.95 (E) min (YMC_C18 150¡Á4.6 mm, 3 mum, A: 9H2O+1 ACN/0.1 TEA/pH6.5 AcetAc, B: 1H2O+9 ACN/0.1 TEA/pH6.5 AcetAc, 0.8 mL/min, 20 C.
With the rapid development of chemical substances, we look forward to future research findings about 199296-40-7.
Reference:
Patent; SANOFI; BOEHM, Claudius; KLEIN, Susanne; NAPIERSKI, Bernard; SOMMER, Christian; US2013/245274; (2013); A1;,
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