Synthetic Route of 667932-24-3 , The common heterocyclic compound, 667932-24-3, name is 2-Ethynylpyridin-4-amine, molecular formula is C7H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Preparation of 3- (2-methoxy-6-trifluoromethylphenyl)-5- (4-aminopyridyl) isoxazole To a solution of [N-HYDROXY- (2-METHOXY-6-TRIFLUOROMETHYLBENZENE)] carboximidoyl chloride (lg, 3. [94MMOL)] and 4-amino-2-ethynylpyridine (310mg, 2. [63MMOL)] in THF was added triethylamine [(550ML,] 3.94mmol). The reaction mixture was stirred at room temperature for one hour and then refluxed for three hours. The mixture was cooled to room temperature, ethyl acetate and water were added. The organic layer was separated, dried over sodium sulfate, filtered and concentrated in vacuo to yield the crude product. The final product [3- (2-METHOXY-6-TRIFLUOROMETHYLPHENYL)-5- (4-AMINOPYRIDYL)] isoxazole (609mg) was obtained by purification with flash chromatography with hexanes: ethyl acetate (4: 1).
The synthetic route of 667932-24-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RIGEL PHARMACEUTICALS, INC.; WO2004/18463; (2004); A2;,
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