The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 145255-19-2, name is 5-Aminopyridine-2-carboxamide. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 5-Aminopyridine-2-carboxamide
2-Chloro-3-fluoro-6-[2-methoxy-4-(trifluoromethoxy)phenoxy]benzoyl chloride was dissolved in THF (2 mL) and cooled to 0 C. DIEA (138 mu, 0.792 mmol) and 5-aminopyridine-2- carboxamide (40 mg, 0.29 mmol) were added and the resulting suspension was stirred at 0 C for 30 minutes and then allowed to warmed to room temperature and stirred for 16 hours. The reaction mixture was diluted with ethyl acetate and washed with water and brine. The organic later was separated, dried by passing through a phase separation cartridge and concentrated in vacuo. Silica gel chromatography (0- 100% ethyl acetate/petroleum ether) provided 5-[[2-chloro-3-fluoro-6-[2-methoxy-4- (trifluoromethoxy)phenoxy]benzoyl]amino]pyridine-2-carboxamide (85 mg, 64%). ESI-MS m/z calc. 499.06, found 500.0 (M+l)+;497.9 (M-l)-; retention time (Method E): 3.01 minutes (5 minute run). NMR (400 MHz, DMSO-d6) delta 11.25 (s, 1H), 8.86 (d, J = 2.4 Hz, 1H), 8.28 (dd, J = 8.6, 2.5 Hz, 1H), 8.09 – 7.99 (m, 2H), 7.56 (s, 1H), 7.49 (t, J = 9.0 Hz, 1H), 7.23 – 7.16 (m, 2H), 6.98 (ddd, J = 8.9, 2.8, 1.3 Hz, 1H), 6.84 (dd, J = 9.3, 3.9 Hz, 1H), 3.77 (s, 3H) ppm.
With the rapid development of chemical substances, we look forward to future research findings about 145255-19-2.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; AHMAD, Nadia; ANDERSON, Corey; ARUMUGAM, Vijayalaksmi; ASGIAN, Iuliana, Luci; CAMP, Joanne, Louise; FANNING, Lev Tyler, Dewey; HADIDA RUAH, Sara, Sabina; HURLEY, Dennis; SCHMIDT, Yvonne; SHAW, David; SHETH, Urvi, Jagdishbhai; THOMSON, Stephen, Andrew; (691 pag.)WO2019/14352; (2019); A1;,
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