Application of 59717-96-3 ,Some common heterocyclic compound, 59717-96-3, molecular formula is C11H8BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Palladium acetate (315 mg, 1.4 mmol), X-PHOS (1.3 g, 2.8 mmol),Dissolved in 10ml 1,4-dioxane, N2 protected at room temperature for 20min, 5-bromo-2-phenoxypyridine (7 g, 28 mmol) was dissolved in 100 ml of 1,4-dioxane.Add bis(pinacolato)diboron(14.42 g, 56 mmol), potassium acetate (8.4 g, 84 mmol),The activated ligand solution is added thereto, and the N2 is protected at 90 C for 12 hours.After completion of the reaction, the diatomaceous earth was filtered under hot water, and the solvent was evaporated under reduced pressure.Obtained white solid 4.24g, yield 51%,The elution system was petroleum ether: ethyl acetate = 100: 1 – 40:1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,59717-96-3, its application will become more common.
Reference:
Patent; Shandong University; Zhao Guisen; Ran Fansheng; Liu Meixia; Liu Yang; Wang Luhua; (48 pag.)CN109369654; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem