Reference of 55876-82-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 55876-82-9, name is Ethyl 5-methylpicolinate. A new synthetic method of this compound is introduced below.
To a solution of methyl 5-methylpyridine-2-carboxylate [Example 2, Step 1] (3 g, 18.3 mmol, 1.00 equiv) in ethanol (20 mL) and tetrahydrofuran (20 mL) was added CaCl2 (8.125 g, 549 mmol 4.00 equiv) and NaBH4 (1.38 g, 36.6 mmol, 2.00 equiv). The resulting solution was stirred overnight at 50 C. The solids were filtered out. The filtrate was concentrated under vacuum. The resulting solution was diluted with ethyl acetate (50 mL). The solids were filtered out. The filtrate was concentrated under vacuum to afford 2.6 g (88.9%) of (5-methylpyridin-2-yl)methanol as light yellow oil. LC-MS: m/z=124[M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,55876-82-9, Ethyl 5-methylpicolinate, and friends who are interested can also refer to it.
Reference:
Patent; Auspex Pharmaceuticals, Inc.; ZHANG, Chengzhi; (94 pag.)US2018/79742; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem