Application of 120740-10-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.120740-10-5, name is (6-Bromopyridin-3-yl)methanamine, molecular formula is C6H7BrN2, molecular weight is 187.0372, as common compound, the synthetic route is as follows.
To the suspension of 9-cyclopentyl-2,6-dichioro-9H-purine (13.6 mmol) in a mixture of n-propanol (60 ml) and N,N-diisopropyl-N-ethylamine (60.0 mmol) C-(6- bromo-pyridin-3-yl)methylamine (15.0 mmol) was added. The suspension was heated with stirring in a sealed tube under an argon atmosphere at the temperature 120 C. for 4 hours. Afier cooling to room temperature the reaction mixture was lefi to stand at 5 C. overnight and the white solid was filtered off and washed with small amount of ice-cooled isopropanol. The crude product was dried at 80 C. for 2 hours and finally crystallized from ethanol. Yield: 71%, m.p.: 178-179 C. Elemental analysis: Calcd. for C,5H,5C113rN5 (407.70): C, 47.14; H, 3.96; N, 20.61. Found: C, 47.35; H, 3.88; N, 20.48. HPLC-MS (ESI+): 409 (98.5%). ?H NMR (DMSO_d5):1.64-1.69 (m, 2H), 1.81-1.96 (m, 4H), 2.09-2.15 (m, 2H),4.61 (s(br), 2H, CH2), 4.77 (qui, J=7.20, 1H, CH), 7.59 (d, J=8.19, 1H, ArH), 7.70 (d, J=8.19, 1H, ArH), 8.26 (s, 1H, CH), 8.38 (s, 1H, ArH), 8.82 (s(br), 1H, NH).
Statistics shows that 120740-10-5 is playing an increasingly important role. we look forward to future research findings about (6-Bromopyridin-3-yl)methanamine.
Reference:
Patent; BIOPATTERNS S.R.O.; UNIVERZITA PALACKEHO V OLOMOUCI; GUCKY, Tomas; JORDA, Radek; ZATLOUKAL, Marek; KRYSTOF, Vladimir; RAROVA, Lucie; REZNICKOVA, Eva; MIKULITS, Wolfgang; STRNAD, Miroslav; (50 pag.)US2015/368248; (2015); A1;,
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