Related Products of 6854-07-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6854-07-5, name is 5-Nitro-2-oxo-3-pyridinecarboxylic Acid, molecular formula is C6H4N2O5, molecular weight is 184.11, as common compound, the synthetic route is as follows.
b) 2-Chloro-5-nitronicotinic acid A solution of 2-hydroxy-5-nitronicotinic acid (9.2 g, 0.05 mol) in phosphorus oxychloride (25 ml) was refluxed for 5 hours. The solvent was removed in vacuo and the residue dissolved in a mixture of tetrahydrofuran and ether. After cooling the solution in an ice bath, water was cautiously added dropwise with stirring until a clean separation of layers was obtained. The organic layer was washed with water and a saturated sodium chloride solution, dried (anhydrous magnesium sulfate) and concentrated. Recrystallization from ether gave 6.94 g (69% of theory) of pure product, m.p. 135 C. (dec).
Statistics shows that 6854-07-5 is playing an increasingly important role. we look forward to future research findings about 5-Nitro-2-oxo-3-pyridinecarboxylic Acid.
Reference:
Patent; Boehringer Ingelheim Pharmaceuticals, Inc.; US5550122; (1996); A;,
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