Adding a certain compound to certain chemical reactions, such as: 6975-44-6, Ethyl 4,6-dihydroxynicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 6975-44-6, blongs to pyridine-derivatives compound. SDS of cas: 6975-44-6
A mixture of scheme 1 compound 2 (8.01 g, 43.7 mmol) and POCl3 (70 mL, 751.1 mmol) was stirred at 110 C for 2h. TLC showed the starting material was consumed completely. After cooling down, most of POCl3 was removed under vacuum. The residue was mixed with ice-water, and neutralized with sodium carbonate solution. The resulting mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous Na2S04 , concentrated to give scheme 1 compound 3 (8.7 g) as a brown solid which was used in the next step immediately without further purification.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6975-44-6, Ethyl 4,6-dihydroxynicotinate, and friends who are interested can also refer to it.
Reference:
Patent; MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.; WO2014/52365; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem