The origin of a common compound about 92138-35-7

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 92138-35-7, 6-Chloro-3-nitropyridin-2(1H)-one.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 92138-35-7, name is 6-Chloro-3-nitropyridin-2(1H)-one. A new synthetic method of this compound is introduced below., Recommanded Product: 6-Chloro-3-nitropyridin-2(1H)-one

Intermediate 63-Aminopyridin-2(l//)-one hydrochlorideTo a stirred solution of 6-chloro-3-nitropyridin-2(lH)-one (Intermediate 5, 3.5 g, 20 mmol) in ethyl acetate (50 mL) was added SnCl2.H2O(32 g, 142 mmol) in portions over a period of 15 min at room temperature, then the mixture was re fluxed at 80 0C for 3 h. The reaction mixture was cooled to room temperature, diluted with ethyl acetate (200 mL) and neutralized with solid NaHCO3 (50 g). The mixture was filtered and the solids were washed with ethyl acetate (2 x 50 mL). The filtrate was concentrated to remove ethyl acetate under vacuum and the residue was taken in ice cold dioxane (20 mL). 4N HCl in dioxane (10 mL) was added and the mixture was concentrated to give desired product in 95%yield (3.5 g, 19 mmol).MS (ES): 143.2 (M-I) for C5H5ClN2O1H-NMR (CDCl3, 300 MHz): delta 4.20 (br s, 2H), 6.20 (d, J= 7.6 Hz, IH), 6.59 (d, J= 7.6 Hz,IH).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 92138-35-7, 6-Chloro-3-nitropyridin-2(1H)-one.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/27732; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem