Oxidant-Induced Azolation of Electron-Rich Phenol Derivatives was written by Wang, Xiaoyu;Wang, Shengchun;Gao, Yiming;Sun, He;Liang, Xing’an;Bu, Faxiang;Abdelilah, Takfaoui;Lei, Aiwen. And the article was included in Organic Letters in 2020.Reference of 51834-97-0 This article mentions the following:
An oxidant-induced intermol. azolation of phenol derivatives was demonstrated under catalyst-free condition. Both monoazolation and diazolation of phenols was successfully achieved via this practical and powerful method. In the experiment, the researchers used many compounds, for example, 5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0Reference of 51834-97-0).
5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Reference of 51834-97-0