Palladium-Catalyzed Site-Selective Amidation of Dichloroazines was written by Young, Ian S.;Glass, Anna-Lena;Cravillion, Theresa;Han, Chong;Zhang, Haiming;Gosselin, Francis. And the article was included in Organic Letters in 2018.Category: pyridine-derivatives This article mentions the following:
A highly site-selective amidation reaction of substituted 2,4-dichloroazines is reported. Palladium acetate/1,1′-bis(diphenylphosphino)ferrocene (dppf) was identified as the optimal catalyst system, producing >99:1 C-2/C-4 selectivity for most examples. The generality of this transformation was demonstrated through a survey of a diverse amide/substituted 2,4-dichloroazine scope, leading to the preparation of the desired C-2 amidated products in good to excellent yields. In the experiment, the researchers used many compounds, for example, 2,4-Dichloro-3-fluoropyridine (cas: 628691-85-0Category: pyridine-derivatives).
2,4-Dichloro-3-fluoropyridine (cas: 628691-85-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Category: pyridine-derivatives