Efficient Pd-Catalyzed C-H Oxidative Bromination of Arenes with Dimethyl Sulfoxide and Hydrobromic Acid was written by Yuan, Yizhi;Liang, Yujie;Shi, Shihui;Liang, Yu-Feng;Jiao, Ning. And the article was included in Chinese Journal of Chemistry in 2020.Safety of 2-(m-Tolyl)pyridine This article mentions the following:
An efficient synthesis of monobromo (hetero)arenes RR1 (R = 4-methyl-2-bromophenyl, 4-phenyl-2-bromophenyl, 4-benzyloxy-2-bromophenyl, etc.; R1 = pyridin-2-yl, 4-methylpyridin-2-yl, isoquinolin-3-yl, etc.), dibromo (hetero)arenes R2R1 (R2 = 2,6-dibromo-4-methylphenyl, 2,6-dibromo-4-methoxyphenyl, 4-benzyloxy-2,6-dibromophenyl, 4-methyloxycarbonyl-2,6-dibromophenyl, 2,6-dibromophenyl) and 10-bromobenzo[h]quinolone through Pd-catalyzed directed C-H bromination protocol, in which DMSO is employed as oxidant with hydrobromic acid aqueous solution (HBr(aq)) as bromide source was developed. The DMSO/HBr(aq) system, which is novel and efficiently utilized in transition-metal catalyzed C-H activation, illustrates its practicability by the operational simplicity, inexpensive and readily available starting materials R3R1 (R3 = 4-methylphenyl, 4-phenylphenyl, 4-benzyloxyphenyl, etc.), and high bromide-atom economy. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Safety of 2-(m-Tolyl)pyridine).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Safety of 2-(m-Tolyl)pyridine