Copper-Mediated One-Pot Synthesis of 2,2-Difluoro-1,3-benzoxathioles from o-Bromophenols and Trifluoromethanethiolate was written by Zhang, Mengjia;Chen, Shouxiong;Weng, Zhiqiang. And the article was included in Organic Letters in 2018.SDS of cas: 13472-81-6 This article mentions the following:
A Cu-mediated difluoromethylenation of o-bromophenols with trifluoromethanethiolate is described. This 1-pot protocol proceeds through an intermol. addition of S:CF2 (resulting from the decomposition of trifluoromethanethiolate) to o-bromophenols followed by intramol. C-S coupling to form 2,2-difluoro-1,3-benzoxathioles. This method is compatible with a broad range of substrates and enables the late-stage difluoromethylenation of several functionally dense drug like o-bromophenols. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6SDS of cas: 13472-81-6).
3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.SDS of cas: 13472-81-6