Metal-free photocatalysts for the oxidation of non-activated alcohols and the oxygenation of tertiary amines performed in air or oxygen was written by Zhang, Yu;Schilling, Waldemar;Riemer, Daniel;Das, Shoubhik. And the article was included in Nature Protocols in 2020.Electric Literature of C12H9NO This article mentions the following:
This protocol described the use of 9-fluorenone as a cheap and non-toxic photocatalyst for oxidation of non-activated alcs. performed under irradiation of a blue light-emitting diode. It also described use of similarly cheap and non-toxic photocatalyst rose bengal for selective α-oxygenation of tertiary amines to produce corresponding amides in a selective way using the same light source. The detailed instructions on how to assemble the light-emitting diode equipment and set up photocatalytic reaction, where an oxygen atm. was created with O2-filled balloon was provided. Further details were provided using four example reactions that illustrate how this system works: alc. oxidation to prepare terephthalaldehyde and androstanedione, and amine oxidation to make 2-phenyl-3,4-dihydroisoquinolin-1(2H)-one and (4-((4-chlorophenyl)(phenylmethyl)piperazin-1-yl)m-tolyl)methanone. The times needed to perform these photocatalytic reactions were 18, 76, 22 and 54 h, resp. It was believe that this protocol represents a robust methodol. for late-stage modification of amines and selective oxidation of steroids. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Electric Literature of C12H9NO).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Electric Literature of C12H9NO