Day: March 3, 2022

Synthetic Route of 1254473-66-9, Adding some certain compound to certain chemical reactions, such as: 1254473-66-9, name is 1-(3,5-Dichloropyridin-4-yl)ethanol,molecular formula is C7H7Cl2NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1254473-66-9.

MsCl (32g, 0.28mol) was added in batches to a solution of a mixture of Example 1E (36g, 0.91mol) and triethylamine (21g, 0.21mol) in dichloromethane (1 L) at 0C. The reaction was stirred at 0C for 3 hours and thenquenched with water (100mL) in an ice bath and stirred for 1 hour. After layering, the organic phase was washed withsaturated sodium bicarbonate solution (200mL 3 3) and brine (200mL), then dried over anhydrous sodium sulfate,filtered and the filtrate was concentrated to give a residue that was purified by flash silica gel column chromatographyto give the title compound (pale yellow, 50g, yield 98%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1254473-66-9, 1-(3,5-Dichloropyridin-4-yl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Harbin Zhenbao Pharmaceutical Co., Ltd.; Medshine Discovery Inc.; CHEN, Shuhui; CHEN, Zhengxia; DAI, Meibi; XIE, Cheng; LI, Peng; ZHANG, Yang; LIANG, Guibai; WANG, Qiang; LIAO, Jiangpeng; SUN, Fei; HU, Guoping; LI, Jian; (166 pag.)EP3333157; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 122306-01-8 ,Some common heterocyclic compound, 122306-01-8, molecular formula is C6H6BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

This compound was synthesised as previously reported and analysis matched with literature values.[30] microscopy of the adjacent tissue immunohistochemically stained with 1E8 antibody. Scale bars indicate 100 mm. (6-Bromopyridin-3-yl)methanol (2) (2.93 g, 11.3mmol) was dissolved in dichloromethane (40mL) and treated with an excess of thionyl chloride (7mL). The reaction was monitored by TLC (33% ethyl acetate in petroleum spirits; Rf 0.81) and once complete, volatiles were removed by evaporation. The residue was then suspended in saturated NaHCO3 (50mL) and extracted with ethyl acetate (2_50mL). The organic extracts were combined, dried over MgSO4, and evaporated to dryness to yield a brown oil, which yielded a crystalline white solid upon standing. The solid was suspended in pentane and isolated by filtration, washed with pentane, and air-dried to give a crystalline colourless solid (2.13 g, 10.3mmol, 91% yield). dH (400MHz, CDCl3) 8.37 (d, 4JHH 1.9, 1H, ArH), 7.60 (dd, 3JHH 8.2, 4JHH 2.4, 1H, ArH), 7.50 (d, 3JHH 8.2, 1H, ArH), 4.54 (s, 2H, CH2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,122306-01-8, its application will become more common.

Reference:
Article; McInnes, Lachlan E.; Noor, Asif; Roselt, Peter D.; McLean, Catriona A.; White, Jonathan M.; Donnelly, Paul S.; Australian Journal of Chemistry; vol. 72; 10; (2019); p. 827 – 834;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 490-11-9, name is Pyridine-3,4-dicarboxylicacid, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives

To a mixture of pyridine-3,4-dicarboxylic acid (10.00 g, 60.00 mmol, 1 eq) and a catalytic amount of DMAP (50 mg) in 300 mL of anhydrous MeOH was added dropwise SOCl2 (21.4 mL, 300.00 mmol, 5 eq) at 0C. The reaction mixture was heated to reflux for 48 h, cooled to room temperature and concentrated in vacuo. The crude product was dissolved in CH2C12 (200 mL), and the solution was washed with saturated K2C03 aqueous solution and water (50 mL), dried over anhydrous Na2S04 and concentrated in vacuo to afford the title compound as pale yellow oil (8.00 g, 68.00 %). The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 196.05 (M+1).

The synthetic route of 490-11-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu; WO2013/71697; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 129012-04-0, Adding some certain compound to certain chemical reactions, such as: 129012-04-0, name is 6-Bromopyridine-2,3-diamine,molecular formula is C5H6BrN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 129012-04-0.

Preparation Example 9-3 5-Bromo-2-methyl-1H-imidazo[4,5-b]pyridine 2,3-Diamino-6-bromopyridine (8.16 g) and triethyl orthoacetate (12.0 ml) were mixed in acetic acid (41 ml), and the mixture was refluxed under heating for 29 hr.. The mixture was allowed to cool and the solvent was evaporated to give a crude product (10 g).. This was dissolved in a sufficient amount of dichloromethane.. Anhydrous potassium carbonate and active carbon were added and the mixture was stirred at room temperature.. The insoluble matter was filtered off and the solvent was evaporated to give the objective compound (7.59 g) as a pale-yellow powder. 1H-NMR(DMSO-d6): 2.51(3H, s), 7.31(1H, d, J=8 Hz), 7.82(1H, d, J=8 Hz) Mass(ESI): m/e 212, 214 (M+H)+

According to the analysis of related databases, 129012-04-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6348474; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 896139-85-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 896139-85-8, name is Imidazo[1,2-a]pyridin-7-ol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of imidazo[l,2-a]pyridin-7-ol (CAS 896139-85-8; 35 mg, 0.26 mmol) in dry DMF (3 mL) is added NaH (60% in mineral oil, 42 mg, 1.04 mmol) and the mixture is stirred at RT for 10 min. Methyl l-bromocyclopentane-l-carboxylate (CAS 51572-54-4; 143 pL, 1.04 mmol) is added and the mixture is heated at 50 C for 20 h. The reaction mixture is concentrated and the residue is diluted with water and DCM. The aqueous phase is extracted with DCM. Organic layers are combined, dried over Na2S04, filtered and concentrated to afford the expected compound. LCMS: MW (calcd): 260.3; m/z MW (obsd): 261.6 (M+H)

According to the analysis of related databases, 896139-85-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GALAPAGOS NV; DESROY, Nicolas; JONCOUR, Agnes, Marie; PEIXOTO, Christophe; TEMAL-LAIB, Taoues; TIRERA, Amynata; BUCHER, Denis; AMANTINI, David; DE VOS, Steve, Irma, Joel; BRYS, Reginald, Christophe, Xavier; (396 pag.)WO2019/238424; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 19842-08-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19842-08-1, name is 2-Bromo-5-ethylpyridine. A new synthetic method of this compound is introduced below.

Example 13A 5-Ethyl-2-(tributylstannyl)pyridine 2250 mg (12 mmol) of 2-bromo-5-ethylpyridine [prepared analogously to J. Org. Chem., 2003, 2028 and Chem. Commun., 2000, 951] and 4330 mg (13.3 mmol) of tributyltin chloride are dissolved in 20 ml of THF, and 8.3 ml (13.3 mmol) of 1.6 N n-butyllithium in hexane are added dropwise at 0 C. The mixture is stirred at 0 C. for 2.5 h and at RT for 12 h. The reaction mixture is diluted with dichloromethane and washed with ammonium chloride solution and saturated sodium chloride solution, and the organic phase is dried over sodium sulfate and concentrated on a rotary evaporator. The crude product is chromatographed on silica gel (dichloromethane, then ethyl acetate). This gives 155 mg (25% of theory) of the title compound. LC-MS (method 6): Rt=1.81 min; m/z=397 (M+H)+. 1H-NMR (400 MHz, DMSO-d6): delta=8.55 (d, 1H), 7.46 (dd, 1H), 7.35 (d, 1H), 2.56 (q, 2H), 1.52 (t, 6H), 1.29 (m, 6H), 1.21-1.01 (m 6H), 0.87 (t, 9H), 0.83 (t, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19842-08-1, 2-Bromo-5-ethylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; US2011/166163; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 73112-16-0, 2,6-Dibromo-4-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 73112-16-0, blongs to pyridine-derivatives compound. Product Details of 73112-16-0

1A Preparation of 2-bromo-4-methyl-6-(3-trifluoromethyl-1H-pyrazol-1-yl)-pyridine A mixture of 2,6-dibromo-4-methylpyridine (33 mmol, obtained according to the method disclosed by WO 94/22833), 3-trifluoromethyl-1H-pyrazole (21 mmol), potassium carbonate (45 mmol) and N,N-dimethylformamide ((50mL) is heated at 90 C for 4 hours. The reaction mixture is partitioned between ethyl acetate ands water. The separated organic phase is washed with brine, dried over sodium sulfate and evaporated in vacuoto provide an oily residue which is purified by flash chromatography. To yield 1.9 g of the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,73112-16-0, 2,6-Dibromo-4-methylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; BASF AKTIENGESELLSCHAFT; EP1101764; (2001); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 89488-30-2, 5-Bromo-3-methylpyridin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 5-Bromo-3-methylpyridin-2(1H)-one, blongs to pyridine-derivatives compound. Recommanded Product: 5-Bromo-3-methylpyridin-2(1H)-one

To a mixture of compound 4b2 (2 g, 10.6 mmol) and CH2CI2 (100 mL) is added Ag2CO3 (8.8 g, 31.9 mmol) and CH3I (7 mL, 112 mmol). The reaction mixture is stirred at room temperature overnight, then filtered through diatomaceous earth (Celite). The filtrate is concentrated under reduced pressure to give compound4b3.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,89488-30-2, 5-Bromo-3-methylpyridin-2(1H)-one, and friends who are interested can also refer to it.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GmbH & CO KG; WO2008/67644; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1159820-58-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1159820-58-2, name is 5-Bromo-2-isopropylpyridine, molecular formula is C8H10BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation of 2-isopropyl-5-vmyl-py?dme[0369] The title compound was prepared by following general procedure 2 5-Bromo-2- lsopropyl-py?dme (0 75 g, 3 7 mmol) was dissolved in DMF THF (3 1, 6 mL) T?butylvmyltm (1 2 mL, 4 12 mmol) and Pd(PPh3)4 (0 070 g, 0 06 mmol) was added to this solution at RT under nitrogen and was heated at 1000C for 30 mm The reaction mixture was cooled to RT and diluted with water (60 mL) and extracted with DCM (3 x 100 mL) The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure below 400C The crude was purified through column chromatography (90% DCM-Hexane in silica 100-200 mesh, Diameter of column – 5 0 cm, Height of silica – approx 5 inch) to provide 2-isopropyl-5- vmylpy?dme as a light yellow liquid (0 5 g, 90% yield)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1159820-58-2, 5-Bromo-2-isopropylpyridine.

Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; HUNG, David, T.; PROTTER, Andrew, Asher; JAIN, Rajendra, Parasmal; CHAKRAVARTY, Sarvajit; GIORGETTI, Marco; WO2010/51503; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 94220-38-9, 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H6ClN3, blongs to pyridine-derivatives compound. COA of Formula: C7H6ClN3

EXAMPLE 4 7-(4-Hydroxyanilino)-5-methyl-1H-pyrazolo[4,3-b]pyridine (E4) STR17 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (0.5 g, 3 mmol) and 4-aminophenol (0.65 g, 6 mmol) in dry xylene (5 ml) were heated under reflux under nitrogen for 7 h. The resulting solid was collected and washed with water and ethyl acetate, then crystallized from methanol/ethyl acetate to give the hydrochloride salt of the required product (393 mg, 47%), m.p. 308-310 C. (dec.). The hydrochloride salt (355 mg, 1.28 mmol) was dissolved in water (20 ml) and methanol (10 ml) and the solution was adjusted to pH7 with 10% sodium carbonate, to give the title compound as yellow needles (283 mg, 92%), m.p. 174-176 C. (Found: C, 59.30; H, 5.36; N, 21.24. C13 H12 N4 O.1.25.H2 O requires C, 59.42 H, 5.56; N, 21.32).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,94220-38-9, 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine, and friends who are interested can also refer to it.

Reference:
Patent; Beecham Group p.l.c.; US4576952; (1986); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem