Month: March 2022

Adding a certain compound to certain chemical reactions, such as: 84487-15-0, 2-Bromo-5-nitropyridin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 84487-15-0, blongs to pyridine-derivatives compound. SDS of cas: 84487-15-0

Step A: 5-tert-Butyl-2-methyl-2H-pyrazole-3-carboxylic acid (2-bromo-5-nitro-pyridin-4-yl)-amide A solution of 2-bromo-5-nitro-pyridin-4-ylamine (62 mg, 0.28 mmol) in THF (5 mL), was treated with NaH (34 mg, 0.85 mmol) under Ar. The resulting solution was stirred for 10 min and then treated with 5-tert-butyl-2-methyl-2H-pyrazole-3-carbonyl chloride (62 mg, 0.31 mmol) in THF (1 mL). The resulting mixture was stirred at room temperature for 1 h. The resulting mixture was purified by direct application to silica preparative TLC plates (2000 micron) and eluted with 3:7 EtOAc-hexanes to yield 5-tert-butyl-2-methyl-2H-pyrazole-3-carboxylic acid (2-bromo-5-nitro-pyridin-4-yl)-amide. 1H-NMR (400 MHz, CDCl3) delta: 11.2 (s, 1H), 9.18 (s, 1H), 9.11 (s, 1H), 6.65 (s, 1H). 4.18 (s, 1H), 1.34 (s, 9H).

The synthetic route of 84487-15-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PLAYER, Mark R.; Calvo, Raul; Chen, Jinsheng; Meegalla, Sanath; Parks, Daniel; Parsons, William; Ballentine, Scott; Branum, Shawn; US2011/218197; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 69045-83-6 ,Some common heterocyclic compound, 69045-83-6, molecular formula is C6H2Cl5N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

After adding 26.5 g (0.1 mol) of 2,3-dichloro-5-trichloromethyl pyridine and 16 g (0.4 mol) of hydrazine hydrate 80% to the reaction kettle, 1000 ml of absolute ethanol was added and reacted at 30 C for 5 hours. Using HPLC analysis, after passing the control, The solvent is distilled off and the product is filtered under reduced pressure to give 2,3-dichloro-5-trichloromethylpyridine. The product yield is 95% and the purity is 99.15%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 69045-83-6, 2,3-Dichloro-5-(trichloromethyl)pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Anhui Guoxing Biochemical Co., Ltd.; Gu Shunming; Zhao Weide; Fu Shenghui; Zhang Mingxiang; Zhao Guangfu; Xian Bin; (5 pag.)CN106748992; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1254473-66-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1254473-66-9, name is 1-(3,5-Dichloropyridin-4-yl)ethanol, molecular formula is C7H7Cl2NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediate 11Freshly activated 4A molecular sieves (7.08 g) and NMO (5.53 g, 47.3 mmol) were added to a stirred solution of Intermediate 10 (3.63 g, 18.9 mmol) in DCM (125 ml). After 15 minutes TPAP (332 mg, 0.945 mmol) was added and the mixture was stirred at rt for 45 minutes. The reaction mixture was filtered through Celite and the filtrate was concentrated. The residue was purified by flash column chromatography on silica gel in 5:1 petrol-ethyl acetate to give a yellow oil (2.57 g, 72%). H NMR (400 MHz, DMSO-de) delta ppm 2.59 (s, 3 H), 8.76 (s, 2 H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1254473-66-9, 1-(3,5-Dichloropyridin-4-yl)ethanol.

Reference:
Patent; MEDICAL RESEARCH COUNCIL TECHNOLOGY; CHAN, Brayn; ESTRADA, Anthony; SWEENEY, Zachary; MCIVER, Edward Giles; WO2011/141756; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 107867-51-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 107867-51-6, name is 5-(Trifluoromethyl)pyridine-2,3-diamine. This compound has unique chemical properties. The synthetic route is as follows.

8-Aza-6-trifluoromethyl-1,4-dihydroquinoxaline-2,3-dione (52) A mixture of 51 (800 mg, 4.52 mmol) and diethyl oxalate (7.0 g, 47.9 mmol) was heated at 160 C. with stirring for 2 h (the mixture turned into a solution, then more and more precipitate was formed) and cooled to room temperature. The mixture was diluted with hexane (20 mL), filtered, washed with hexane (3*5 mL), and dried to give 997 mg (94%) of 52 as a yellow powder, mp >360 C. 1 H NMR (DMSO-d6), 7.625 (s, 1H), 8.441 (s, 1H), 12.120 (s, 1H), 12.703 (s, 1H). 19 F NMR (DMSO-d6), -131.225 ppm (The internal standard C6 F6: -162.9 ppm).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 107867-51-6, 5-(Trifluoromethyl)pyridine-2,3-diamine.

Reference:
Patent; State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University and The University of Oregon, Eugene Oregon; The Regents of the University of California; ACEA Pharmaceuticals, Inc.; US5620978; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 61494-55-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 61494-55-1, name is 2-(2-Chloropyridin-3-yl)acetic acid. This compound has unique chemical properties. The synthetic route is as follows.

INTERMEDIATE 15; 2-(“2-Chloropyridin-3-yl)-N-methoxy-iV-methylacetamide; Intermediate 12 (500 mg, 2.9 mmol) in dichloromethane (20 mL) with N, O- dimethylhydroxylamine (300 mg, 3.04 mmol), EDC (583 mg, 3.04 mmol) and N-methyl- morpholine (0.98 mL, 8.70 mmol) were stirred at r.t. for 18 h. The reaction mixture was washed with 2M HCl, and the organic phase was dried (magnesium sulphate) and concentrated in vacuo. Chromatography (SiO2; 1:1 ethyl acetate:DCM) yielded the title compound (320 mg) as a white solid. deltaH(DMSO-d6) 8.31 (IH, dd, J A.I, 1.9 Hz), 7.81 (IH, dd, Jl.5, 1.9 Hz), 7.40 (IH, dd, J7.5, 4.7 Hz), 3.93 (2H, s), 3.76 (3H, s), 3.15 (3H, s). LCMS (ES+) RT 2.22 minutes, 215/217 (M+H)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 61494-55-1, 2-(2-Chloropyridin-3-yl)acetic acid.

Reference:
Patent; UCB PHARMA S.A.; WO2007/88345; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1214326-89-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1214326-89-2, name is 3-Bromo-5-fluoropyridin-4-amine. A new synthetic method of this compound is introduced below.

A mixture of 4-bromo-2-fluoro-pyridin- 3-amine (2.29 g, 12.0 mmol) and potassium ethoxymethanedithioate (3.85 g, 24.0 mmol) in NMP (12 mL) was heated in a microwave at 170 C for 45 min when the reaction mixture turned dark red. The reaction mixture was cooled to 23 C, poured into AcOH and water (10% v/v, 200 mL). The resulting precipitate was collected by filtration to give the title compound (2.94 g, 99% yield) as yellow solid. 1H NMR (400 MHz, DMSO-d6) delta 8.72 (s, 1H), 8.60 (s, 1H). LCMS m/z: 249 [M+H+].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1214326-89-2, 3-Bromo-5-fluoropyridin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; GANCIA, Emanuela; LAI, Yingjie; LIANG, Jun; MACLEOD, Calum; MAGNUSON, Steven, R.; SAJAD, Mohammed; TSUI, Vickie, H.; WILLIAMS, Karen; ZHANG, Birong; WO2015/91584; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6623-21-8, name is 4,6-Dimethylnicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4,6-Dimethylnicotinonitrile

(i) 3-Cyano-4,6-dimethylpyrid-2-thione was prepared from 3-cyano-4,6-dimethylpyridine and thiourea following the procedure of Guerrara, Siracusa and Tornetta (I1, Farmaco Ed. Sc. 31, 21, 1975), and was obtained as yellow needles, mp 245-250.

With the rapid development of chemical substances, we look forward to future research findings about 6623-21-8.

Reference:
Patent; ICI Australia Limited; US4631081; (1986); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 7477-10-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7477-10-3, name is 6-Chloro-5-nitronicotinic acid, molecular formula is C6H3ClN2O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

6-(Cyclohexylamino)-5-nitronicotinic acid (57) To a solution of intermediate 56 (10.1 g, 49.9 mmol) and triethylamine (14.6 mL, 125.0 mmol) in acetonitrile (130 mL) and DMSO (25 mL) was added cyclohexylamine (13.7 mL, 100 mmol). The reaction mixture was heated to reflux (90 C.) under a nitrogen atmosphere for 20 h. The reaction mixture was cooled to rt and concentrated on a rotary evaporator and the residue was dissolved in 800 mL 1N sodium hydroxide solution. This solution was washed with dichloromethane (3*75 mL) and then made acidic (pH=5) with concentrated hydrochloric acid. The precipitated product was collected by vacuum filtration and washed sparingly with cold water to afford the HCl salt of intermediate 57 as a yellow solid (9.8 g, 65%). ESI-MS m/e 266.2 (M+1).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7477-10-3, 6-Chloro-5-nitronicotinic acid.

Reference:
Patent; Priestley, Eldon Scott; Decicco, Carl P.; Hudyma, Thomas W.; Zheng, Xiaofan; US2003/134853; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1235036-15-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1235036-15-3 as follows.

To a solution of tert-butyl 3-bromo-6-chloropicolinate (5.92 g) in tetrahydrofuran (60mL)and water (30 mL) was added the crude Example 1.20.1 (4.44 g), 1,3,5,7-tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamante (1.5 g), tris(dibenzylideneacetone)dipalladium(O) (927 mg) and20 K3P04(22 g). The mixture was stirred at reflux overnight, cooled, diluted with ethyl acetate (800 mL)25and washed with water and brine. The organic layer was dried over sodium sulfate, filtered, andconcentrated. The residue was purified by flash chromatography, eluting with 20% ethyl acetate inheptane followed by 5% methanol in dichloromethane, to give the title compound. MS (ESI) m/e531.1 (M+Ht.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1235036-15-3, its application will become more common.

Reference:
Patent; ABBVIE INC.; BOGHAERT, Erwin, R.; SOUERS, Andrew, J.; PHILLIPS, Andrew, C.; JUDD, Andrew, S.; BRUNCKO, Milan; (717 pag.)WO2017/214282; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 73998-96-6, Adding some certain compound to certain chemical reactions, such as: 73998-96-6, name is 2,4-Dichloro-5-(chloromethyl)pyridine,molecular formula is C6H4Cl3N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 73998-96-6.

PREPARATION EXAMPLE 52-3 In the same manner as in Preparation Example 18-4, methyl 3-((2,4-dichloropyridin-5-yl)methyl)-2-methyl-1H-imidazo[4,5-b]pyridine-5-carboxylate was obtained as pale-yellow crystals (640 mg), and methyl 1-((2,4-dichloropyridin-5-yl)methyl)-2-methyl-1H-imidazo[4,5-b]pyridine-5-carboxylate as a yellow oil, from methyl 2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate (650 mg) and 5-chloromethyl-2,4-dichloropyridine (723 mg).

According to the analysis of related databases, 73998-96-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Fujisawa Pharmaceutical Co. Ltd.; US6573274; (2003); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem