Electric Literature of 1195-59-1 , The common heterocyclic compound, 1195-59-1, name is 2,6-Pyridinedimethanol, molecular formula is C7H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example A Preparation of 2,6-bis(chloromethyl)pyridine To 100 mL of thionyl chloride that was cooled (ice bath) was added 24 g (0.17 mol) of 2,6-bis(hydroxymethyl)pyridine. After 30 min, the reaction mixture was warmed to room temperature, then refluxed for 1.5 hrs. After cooling the reaction mixture to room temperature, the solid which formed was filtered, washed with benzene and dried in vacuo. The solid was then neutralized with saturated NaHCO3, filtered and dried to yield 23.1 g (71.5%) of the titled product as an off-white crystalline solid, mp 74.5-75.5 C., and further characterized by: 1 H NMR (CDCl3); delta 4.88 (s, 4H), 7.25-7.95 (m, 3H).
The synthetic route of 1195-59-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; The Dow Chemical Company; The University of Texas; US5834456; (1998); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem