Category: 1195-59-1

Synthetic Route of 1195-59-1 , The common heterocyclic compound, 1195-59-1, name is 2,6-Pyridinedimethanol, molecular formula is C7H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A) Synthesis of 2,6-bis-(chloromethyl)pyridine To thionyl chloride (11.6 ml, 158 mmoles), cooled at 0 C., 2,6-bis-(hydroxymethyl)pyridine (4 g, 28 mmoles) is added very slowly. The obtained solution is left under stirring for 2 hours at room temperature, then the thionyl chloride in excess is evaporated at a reduced pressure. The obtained residue is treated with chloroform and it is evaporated again at a reduced pressure to remove the thionyl chloride residues. The raw product is treated with chloroform and washed with water. The organic phase is anhydrified with sodium sulphate and dried obtaining 4.81 g of the product as white solid having melting point=76-78 C.

The synthetic route of 1195-59-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Del Soldato, Piero; Benedini, Francesca; Antognazza, Patrizia; US2004/23933; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1195-59-1 , The common heterocyclic compound, 1195-59-1, name is 2,6-Pyridinedimethanol, molecular formula is C7H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example A Preparation of 2,6-bis(chloromethyl)pyridine To 100 mL of thionyl chloride that was cooled (ice bath) was added 24 g (0.17 mol) of 2,6-bis(hydroxymethyl)pyridine. After 30 min, the reaction mixture was warmed to room temperature, then refluxed for 1.5 hrs. After cooling the reaction mixture to room temperature, the solid which formed was filtered, washed with benzene and dried in vacuo. The solid was then neutralized with saturated NaHCO3, filtered and dried to yield 23.1 g (71.5%) of the titled product as an off-white crystalline solid, mp 74.5-75.5 C., and further characterized by: 1 H NMR (CDCl3); delta 4.88 (s, 4H), 7.25-7.95 (m, 3H).

The synthetic route of 1195-59-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Dow Chemical Company; The University of Texas; US5834456; (1998); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1195-59-1, name is 2,6-Pyridinedimethanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 1195-59-1

At 0 C, a solution of p-toluenesulfonyl chloride (0.76 g,4.0 mmol) in tetrahydrofuran (THF; 7.5 mL) was added to a stirred solution of 2,6-pyridinedimethanol (0.28 g, 2.0 mmol) and NaOH (0.8 g, 20 mmol) in THF/water (7.5/7.5 mL). After 4 h of stirring, the mixture was poured into 20 mL of water and extracted with methylene chloride (3 × 7.5 mL). The organic phase was washed with saturated aqueous NaCl solution and distilled water and dried over Na2SO4; the solvent was removed in vacuo to afford 2,6-pyridinedimethylene ditosylate (0.79 g, 88%) as a white powder. 1H NMR(300 MHz, CDCl3): = 7.80 (d, J = 7.5 Hz, 4H, 2,6-H tosyl), 7.69 (t,J = 7.5 Hz, 1H, 4-H Py), 7.32 (d, 2H, 3,5-H Py, d, 4H, 3,5-H tosyl), 5.04(s, 4H, PyCH2tosyl), and 2.44 (s, 6H, tosyl-CH3)

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Reference:
Article; Woo, Jeong Oh; Kang, Sung Kwon; Park, Jong-Eun; Son, Kyung-Sun; Journal of Molecular Catalysis A: Chemical; vol. 404-405; (2015); p. 204 – 210;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1195-59-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1195-59-1 as follows.

Example 15 2,6-Bis(bromomethyl)pyridine. To pyridine-2,6-diyldimethanol (2 g, 14 mmol) was added 60% HBr (15 mL) slowly. The reaction was heated at 125 C. for 6 h then cooled to room temperature. The resulting residue was dissolved in H2O (50 mL) to give a yellow solution. To this solution was added saturated NaHCO3 to pH 8. The resulting aqueous solution was extracted with CH2Cl2 (4×50 mL), and the combined organic layers were dried over Na2SO4. The solvent was removed by rotary evaporation, and the resulting material was purified by flash column chromatography (EtOAc/hexanes, 1:9-1:4) to yield 2,6-bis(bromomethyl)pyridine (3.5 g, 96%) as a white solid: 1H NMR (500 MHz, CDCl3) delta 4.53 (s, 4H), 7.36-7.38 (d, J=8.0 Hz, 2H), 7.68-7.71 (dd, J=7.5, 8.0 Hz, 1H); 13C NMR (125 MHz, CDCl3) delta 33.8, 123.1, 138.4, 157.0; LC-TOF (M+H+) calcd for C7H8Br2N 263.90235, found 263.90193.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1195-59-1, its application will become more common.

Reference:
Patent; Silverman, Richard B.; Xue, Fengtian; US2010/203613; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1195-59-1, Adding some certain compound to certain chemical reactions, such as: 1195-59-1, name is 2,6-Pyridinedimethanol,molecular formula is C7H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1195-59-1.

A solution of (b) (1.39 g, 10 mmol) in 35 mL of CH2Cl2 was added to a 40% aqueous solution of KOH (35 mL). The reaction mixture was cooled at 0 C and stirred for 30 min, after which a solution of p-toluenesulfonyl chloride (3.81 g, 20 mmol) was added in one portion. The reaction mixture was stirred for 1 h at 0 C and then at room temperature until complete conversion (TLC, 1/4 methanol/toluene). The reaction mixture was added to water (35 mL). The aqueous phase was extracted with CH2Cl2 (3 * 20 mL), the combined organic phase was dried over anhydrous MgSO4, filtered, and the solvent was removed under reduced pressure to afford a white crystalline solid (3.89 g, 87%) with Mp 119-121 C (121-122 C in [28] ). FT-IR (solid, cm-1): 3070, 3038 nu (C-H), 1596 nu (Cfx1C), 743 delta (C-H). 1H NMR (CDCl3), deltaH ppm: 2.46 (s, 6H, CH3), 5.08 (s, 4H, CH2), 7.34-7.83 (m, 11H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1195-59-1, 2,6-Pyridinedimethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Aghatabay, Naz Mohammed; Altun, Ahmet; Guerbuez, Mustafa Ulvi; Tuerkyilmaz, Murat; Comptes Rendus Chimie; vol. 17; 9; (2014); p. 905 – 912;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1195-59-1, name is 2,6-Pyridinedimethanol. A new synthetic method of this compound is introduced below., Recommanded Product: 1195-59-1

The 2,6-dimethylolpyridine (10.0g, 71. 9mmol) by adding 250 ml three flasks, constant voltage used in the dropping funnel slowly dropping 48% of HBr (95 ml) solution dissolved, after maintaining the 60 C magnetic stirring for 19 hours. After the end of the reaction cooled to the room temperature, and then to continue to use the ice ice salt bath cooling and saturation of the sodium accent carbonate to alkaline. The generated white solid after filtering, washing several times with distilled water, then the n-hexane recrystallization under the room temperature condition, to obtain the colorless transparent acicular crystal (12.3g, 65%). Mass spectrum: ES – MS (CH3CN), m/z (%): 266.00 (100) [M + H]+. 2. 6 – dibromo methyl pyridine (B) in acetonitrile electrospray mass spectrum chart of Figure 1.

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Reference:
Patent; Nanjing University; WANG, ZHILIN; GENG, ZHIRONG; (25 pag.)CN106518896; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 1195-59-1, Name is 2,6-Pyridinedimethanol, SMILES is OCC1=NC(CO)=CC=C1, in an article , author is Sitter, James D., once mentioned of 1195-59-1, Recommanded Product: 1195-59-1.

Photocatalytic Oxidative Coupling of Arylamines for the Synthesis of Azoaromatics and the Role of O-2 in the Mechanism

The photocatalytic oxidative coupling of aryl amines to selectively synthesize azoaromatic compounds has been realized. Multiple different photocatalysts can be used to perform the general reaction; however, Ir(dF-CF3-ppy)(2)(dtbpy)(+), where dF-CF3-ppy is 2-(2,4-difluorophenyl)-5-(trifluoromethyl)-pyridine and dtpby is 4,4′-tert-butyl-2,2′-bipyridine, showed the greatest range of reactivity with various amine substrates. Both electron-rich and -deficient amines can be coupled with yields up to 95% under an ambient air atmosphere. Oxygen was deemed to be essential for the reaction and is utilized in the regeneration of the photocatalyst. Fluorescence quenching and radical trap experiments indicate an amine radical coupling mechanism that proceeds through a hydrazoaromatic intermediate before further oxidation occurs to form the desired azoaromatic products.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In an article, author is Rana, Masud, once mentioned the application of 1195-59-1, Application In Synthesis of 2,6-Pyridinedimethanol, Name is 2,6-Pyridinedimethanol, molecular formula is C7H9NO2, molecular weight is 139.15, MDL number is MFCD00006351, category is pyridine-derivatives. Now introduce a scientific discovery about this category.

Multifunctional Effects of Sulfonyl-Anchored, Dual-Doped Multilayered Graphene for High Areal Capacity Lithium Sulfur Batteries

Li-S batteries (LSBs) require a minimum 6 mAh cm(-2) areal capacity to compete with the state-of-the-art lithium ion batteries (LIBs). However, this areal capacity is difficult to achieve due to a major technical issue-the shuttle effect. Nonpolar carbon materials limit the shuttle effect through physical confinement. However, the polar polysulfides (PSs) only provide weak intermolecular interactions (0.1-0.7 eV) with these nonpolar carbon materials. The physically encapsulated PSs inside the nonpolar carbon scaffold eventually diffuses out and starts shuttling. Chemically interactive hosts are more effective at interacting with the PSs due to high binding energies. Herein, a multifunctional separator coating of nitrogen-doped multilayer graphene (NGN) and -SO3- containing Nafion (N-NGN) is used to mitigate PS shuttling and to produce a high areal capacity LSB. The Nafion is used as a binder instead of PVDF to provide an additional advantage of -SO3- to chemically bind the PS. The motive of this research is to investigate the effect of highly electronegative N and -SO3- (N-NGN) in comparison with the -OH, -COOH, and -SO3- groups from a hydroxyl graphene and Nafion composite (N-OHGN) to mitigate PS shuttling in LSBs. The highly conductive doped graphene architecture (N-NGN) provides efficient pathways for both electrons and ions, which accelerates the electrochemical conversion at high sulfur loading. Moreover, the electron-rich pyridine N and -SO3- show strong chemical affinity with the PS through polar-polar interactions, which is proven by the superior electrochemical performance and density functional theory calculations. Further, the N-NGN (5 h) produces a maximum areal capacity of 12.0 and 11.0 mAh cm(-2) , respectively, at 15 and 12 mg cm(-2) sulfur loading. This areal capacity limit is significantly higher than the required areal capacity of LSBs for commercial application, which shows the significant strength of N-NGN as an excellent separator coating for LSBs.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 1195-59-1, Name is 2,6-Pyridinedimethanol, formurla is C7H9NO2. In a document, author is Dey, Sunanda, introducing its new discovery. Formula: C7H9NO2.

The oxidative dehydrogenation of a coumarinyl scaffold with copper ion and metal ion detection in human liver cancer cells (HepG2)

An unsymmetrical o-phenylenediamine derivative, L (7-hydroxy-4-methyl-8-(1-(phenyl- (pyridin-2-yl)methyl)-1H-benzo[d]imidazol-2-yl)-2H-chromen-2-one), has been synthesized from (E)-N-1-(phenyl(pyridine-2-yl)methylene)benzene-1,2-diamine with 7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde and characterized by X-ray, IR, H-1 NMR and ESI-MS spectral analyses. The X-ray structure shows L as a cyclic benzimidazole derivative, but it undergoes ring-opening upon reaction with transition metal ions. L is non-emissive in 9:1 (v/v) EtOH/H2O (HEPES buffer, pH 7.4) but becomes highly fluorescent upon Zn2+ coordination, and the emissive Zn(ii) complex undergoes transmetallation in the presence of Cu2+ ions specifically, followed by amine to imine oxidation, i.e. an oxidative dehydrogenation (OD) reaction -(2e + 2H(+)) occurs. The transmetallation of Zn2+ from the complex by Cu2+ (CuCl2) separated the non-emissive X-ray diffractable crystal of [Cu(L)Cl] (L = amine oxidized form of L). A square pyramidal [Cu(L)][ClO4] complex was also isolated from the reaction of L with Cu(CH3CN)(4)(ClO4) in the presence of air, and in this complex the amine is also oxidized to the imine. Here, copper ions in the presence of air play an important role in the OD reaction of L as determined by EPR and cyclic voltammetry studies. The ligand, L, is used for Zn2+ ion recovery from a municipally supplied water sample. A paper strip detection kit for Zn2+ and Cu2+ is designed using L. The ligand is also used for intracellular Zn2+ detection in a human liver cancer cell line (HepG2).

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1195-59-1 help many people in the next few years. Formula: C7H9NO2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 1195-59-1, Name is 2,6-Pyridinedimethanol, SMILES is OCC1=NC(CO)=CC=C1, belongs to pyridine-derivatives compound. In a document, author is Wang, Qi-Bao, introduce the new discover, Category: pyridine-derivatives.

Synthesis, structure, and heterogeneous Fenton reaction of new Cu(II)-based discrete Cu2Lx coordination complexes

Discrete and polymeric coordination complexes, namely (Cu2L4(ClO4)(4)]center dot 2CH(2)Cl(2)center dot CH3OH (1), [Cu2L2(NO3)(4)(CH3OH)(2)] (2) and {[Cu2L4(NO3)(4)]}(n), (3), were obtained using bridged pyridine ligand 4-methyl-2,6-bis(pyridinyl-3-ethynyl)aniline (L) and Cu(n) salts in CH2Cl2/MeOH. The structure of the Cu2L4 cage or Cu2L2 macrocycle was generated depending on the selection of the anion (ClO4-/NO3-). The heterogeneous Fenton reaction experiments using H2O2 showed that discrete coordination complexes are good photocatalysts in which the Cu-N bond plays a major role in the photocatalytic degradation. The degradation mechanism could be described as a synergistic process of the Fenton reaction and high-valence copper ions using t-butanol as the hydroxyl radical scavenger. The photocatalytic degradation of methylene blue (MB) experiments showed that the photodegradation efficiency of the coordination complexes is higher than that of the polymeric Cu-MOFs.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1195-59-1 is helpful to your research. Category: pyridine-derivatives.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem