Ruthenium-Catalyzed Meta-Selective C-H Difluoromethylation of Phenol Derivatives was written by Xu, Xu;Tao, Na;Fan, Wei-Tai;Tu, Guangliang;Geng, Jingyao;Zhang, Jingyu;Zhao, Yingsheng. And the article was included in Journal of Organic Chemistry in 2020.Synthetic Route of C11H9NO This article mentions the following:
With pyrimidine as the directing group, we achieved the meta-selective difluoromethylation of phenol derivatives using ruthenium as a catalyst. This synthetic scheme provided an efficient method for the syntheses of fluorine-containing phenol derivatives A wide variety of phenol derivatives were well-suited, affording the corresponding products in moderate-to-good yields. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Synthetic Route of C11H9NO).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six 闂?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H闂佹椿浜滈妴鍗l criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Synthetic Route of C11H9NO