Category: pyridine-derivatives

Kao, Sheng-Yuan published the artcileAchieving a large contrast, low driving voltage, and high stability electrochromic device with a viologen chromophore, Name: 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, the publication is Journal of Materials Chemistry C: Materials for Optical and Electronic Devices (2015), 3(14), 3266-3272, database is CAplus.

The viologen radical salt (VRS), consisting of Ph viologen (PV) dications and 2,2,6,6-tetramethyl-1-piperidinyloxy derivative (TEMPOD) anions, was successfully synthesized. The VRS was combined with N,N,N’,N’-tetramethyl-p-phenylenediamine (TMPD) to form an electrochromic device (ECD). This ECD offers significant transmittance changes (>60% at both 580 and 620 nm), but only requires 0.4 V for switching, the lowest driving voltage ever reported. Such a low driving voltage further strengthens the energy-saving capability of the ECD. The incorporation of TEMPOD in the ECD greatly improved its write-erase ability while insufficient bleaching was clearly observed within only 5 cycles in the case of its counterpart without adding TEMPOD anions. No significant decay in the transmittance change was noticed in the proposed ECD after subjecting to 100 cycles. Even better cycling stability would be expected if counter anions with multiple TEMPO units were utilized.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Name: 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tius, Marcus A. published the artcileSelectivity in aromatic fluorination. Introduction of fluorine probes into nabilone, Computed Properties of 107263-95-6, the publication is Chemical Communications (Cambridge) (1996), 2085-2086, database is CAplus.

Selective fluorination of the aromatic ring of nabilone leads to functional analogs with diminished affinity for the CB1 receptor, thereby confirming the hypothesis that the phenolic hydroxy group is engaged in a hydrogen bonding interaction with the receptor.

Chemical Communications (Cambridge) published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C10H11N3O3S, Computed Properties of 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Higashi, Tomohiro published the artcileTwo Sharp Phase Change Processes of Diphenyl Viologen at a Au(111) Electrode Surface: Non-Faradaic Transition with Interplay of Ionic Adsorption of Chloride and Bromide and Faradaic One, Synthetic Route of 47369-00-6, the publication is Journal of Physical Chemistry C (2015), 119(3), 1320-1329, database is CAplus.

Two phase change processes of di-Ph viologen (dPhV) on a Au(111) electrode in KCl and KBr aqueous solutions were described using the results of voltammetric, electroreflectance (ER), and electrochem. scanning tunneling microscopic (EC-STM) measurements. Both processes exhibited sharp spikelike voltammetric responses. In KCl solution, the phase change at 0.30 V vs. Ag/AgCl/saturated KCl is a nonfaradaic order-disorder phase transition, from an ordered adlayer of dPhV dication (dPhV²⁺) with coadsorbed Cl^– at more pos. potentials than 0.30 V to a gas-like phase at less pos. potentials. The faradaic reaction at -0.09 V is the transition from the gaslike phase to a condensed monolayer of dPhV^â€?. The EC-STM images of the condensed monolayer showed stripe patterns of rows of π-π stacked dPhV^â€?. Almost the same set of two processes was observed in KBr solution but not in KF solution In KF solution, although two voltammetric responses were observed, the peaks were small and broad, indicative of sluggish adsorption state changes of individual dPhV cations. Taken together, specific adsorption of coexistent anions is of critical importance for the occurrence of the sharp nonfaradaic phase transition.

Journal of Physical Chemistry C published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Synthetic Route of 47369-00-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Engin, Seckin published the artcileThe inhibitory effect of trimetazidine on detrusor contractility – a potential repositioning of trimetazidine for the treatment of overactive bladder., Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is The Journal of pharmacy and pharmacology (2022), 74(1), 94-102, database is MEDLINE.

OBJECTIVES: This study aimed to identify the effect of trimetazidine (TMZ), an antianginal drug, on detrusor smooth muscle (DSM) contractility and its possible mechanisms of action. METHODS: We performed in-vitro contractility studies on isolated mouse DSM strips and investigated the effect of TMZ on Ca2+ levels in fura-2-loaded A7r5 cells. KEY FINDINGS: TMZ (300 or 1000 µM) inhibited carbachol (CCh)- and KCl-induced contractions and produced a concentration-dependent (10-1000 µM) relaxation in KCl-precontracted DSM strips. TMZ-induced relaxation was markedly decreased by BaCl2, an inward-rectifying K+ channel blocker, but was not altered by preincubation with tetraethylammonium, glibenclamide, 4-aminopyridine, propranolol, L-NAME or methylene blue. TMZ (300 or 1000 µM) reduced both the CaCl2-induced contraction of depolarized DSM strips under Ca2+-free conditions and the CCh-induced contraction of DSM strips preincubated with nifedipine in Ca2+-containing Krebs solution. Furthermore, TMZ (1000 µM) significantly decreased the Ca2+ levels in fura-2-loaded A7r5 cells. CONCLUSIONS: TMZ decreased DSM contractility and caused a concentration-dependent relaxation of the tissue possibly through its actions on Ca2+ transients and K+ channels. Our results provide preclinical evidence that TMZ would be a potential candidate to treat disorders related to the overactivity of the bladder.

The Journal of pharmacy and pharmacology published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Name: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sano, Tomoharu published the artcileSynthesis of N-(1-Nitropyren-6-yl and 8-yl)-2′-deoxyribonucleosides, HPLC of Formula: 107263-95-6, the publication is Chemical Research in Toxicology (1995), 8(5), 699-702, database is CAplus and MEDLINE.

A new type of 1-nitropyrene-DNA adduct via addition-elimination reaction was synthesized. Treatment of fluorinated 1-nitropyrene with 3′- and 5′-O-protected 2′-deoxyribonucleoside in DMSO at 140 °C afforded N-(1-nitropyren-6-yl or 8-yl)-2′-deoxyribonucleoside, I (R = H, R¹ = NO₂; R =NO₂, R¹ = H). These DNA adducts resulted from addition of the exocyclic amino group of deoxynucleosides to the fluorinated carbon of the fluoro-1-nitropyrene following elimination of fluoride anion. This is the first report that describes the 1-nitropyrene-DNA adducts in which aromatic ring moiety of 1-nitropyrene is covalently linked to the exocyclic amino group of the deoxyribonucleoside. From our findings, we suggest that the addition-elimination reaction may be responsible for the formation mechanism of the putative 1-nitropyrene-DNA adducts in vivo.

Chemical Research in Toxicology published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, HPLC of Formula: 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Perlovich, German L. published the artcileSolubility and Transfer Processes of Some Hydrazones in Biologically Relevant Solvents, Category: pyridine-derivatives, the publication is Journal of Chemical & Engineering Data (2013), 58(9), 2659-2667, database is CAplus.

Solubility values of 20 hydrazones in water, 1-octanol and hexane were determined by the isothermal saturation method. Thermophys. characteristics of fusion processes (m.ps. and fusion enthalpies) of the selected substances were measured by DSC method. The impact of structural modification of the mols. on solubility processes in the solvents was analyzed. Transfer processes from water to 1-octanol and from water to hexane were analyzed. Correlation equations connecting the transfer coefficients with physicochem. descriptors were obtained.

Journal of Chemical & Engineering Data published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Guha, Somraj published the artcileIodine-promoted controlled and selective oxidation of (aryl)(heteroaryl)methanes, Category: pyridine-derivatives, the publication is Journal of Organic Chemistry (2022), 87(8), 5424-5429, database is CAplus and MEDLINE.

Herein, an iodine-catalyzed controlled oxidation of (aryl)(heteroaryl)methanes to (aryl)(heteroaryl)methanols ArCH(O)Ar¹ [Ar = Ph, 2-MeC₆H₄, 4-ClC₆H₄, etc.; Ar¹ = pyridin-2-yl, benzothiazol-2-yl] was disclosed under metal-free reaction conditions. A catalytic system comprised of iodine/silyl chloride with HI as an additive in the presence of DMSO selectively oxidize the C(sp³)-H bonds without being over oxidized to corresponding ketones. Therapeutically important aryl heteroaryl methanol derivatives were obtained in good yields. The preliminary mechanistic investigation proved that the primary source of oxygen was DMSO.

Journal of Organic Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Pham, Duc T. published the artcileAnion/cation layers at electrified interfaces: a comprehensive STM, XRD and XPS case study, Quality Control of 47369-00-6, the publication is Chimia (2009), 63(3), 115-121, database is CAplus.

Charged organic adsorbates play an important role in a number of electrochem. reactions, e.g. as additives for metal plating relevant for device fabrication in the semiconductor industry. Fundamental investigations are mandatory in order to acquire profound knowledge of the structural and electronic properties of these layers parallel and perpendicular to the surface, and to finally achieve a deeper mechanistic understanding of the kinetics of involved charge transfer reactions taking place at these complex metal/organic/electrolyte interfaces. A key structural motif of these interfaces consists in ‘paired’ (inorganic)anion/(organic)cation layers that can have an enormous stability even during an ongoing charge transfer reaction. In this contribution we present and discuss a selected case study on the co-adsorption of halide anions and cationic organic mols. that exhibit a pronounced redox activity. It will be demonstrated that their phase behavior at the interface crucially depends on both their particular redox-state and the surface concentration of the halide counter ions. The subtle balance between adsorbate-adsorbate and adsorbate-substrate interaction of the poly-cationic organic layer can be carefully controlled by potential dependent anion adsorption and desorption processes through the organic layer. This process can be followed by in situ high-resolution scanning tunnelling microscopy, while addnl. information about the structural and chem. state of the resp. phase is obtained from in situ X-ray diffraction and ex situ photoelectron spectroscopy.

Chimia published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Quality Control of 47369-00-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zafar, Sana published the artcileLinear and non linear optical properties of electron donor and acceptor pyridine moiety: a study by ab initio and DFT methods, COA of Formula: C11H8N2O2, the publication is Canadian Journal of Pure & Applied Sciences (2012), 6(1), 1827-1835, database is CAplus.

The Donor-Acceptor type conjugated mol. structures containing pyridine as a bridge were explored for non linear optical properties. The ab-initio Hartree Fock calculations and D. Functional Theory with B3LYP method were carried out employing 6-31 G basis set. The dipole moments (μ), polarizability (α), 1st hyperpolarizability (β), and HOMO-LUMO energy gap are calculated using the same level of theory. The dependence of the hyperpolarizability of different mol. structure on the nature of donor and acceptor on the pyridine is discussed from MO picture. Of all the mol. systems studied, the mol. system containing nitro as an acceptor and dimethylaniline as a donor has largest value of hyperpolarizability; 49.92 × 10^-30 esu and 164.61 × 10^-30 esu with ab-initio/HF and DFT/B3LYP, resp. The large value of β for the Donor-Acceptor pyridine derivative suggests the potential applications of these mol. systems in the development of non linear materials.

Canadian Journal of Pure & Applied Sciences published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C9H6BrNO, COA of Formula: C11H8N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Saha, Debasmita published the artcileIntramolecular cyclization of imidazo[1,2-a]pyridines via a silver mediated/palladium catalyzed C-H activation strategy, HPLC of Formula: 1174626-28-8, the publication is Organic Chemistry Frontiers (2019), 6(13), 2234-2239, database is CAplus.

A C-H activation reaction was developed using imidazo[1,2-a]pyridine adducts via an AgOAc-mediated, Pd catalyzed intramol. cyclization for the preparation of tetrazolylpyridoimidazo[4,5-c]quinoline derivatives I (R¹ = H, 9-Me, 9-Br, etc.; R² = t-Bu, Bn, cyclohexyl, etc.). The reaction was optimized and extensively explored using the Ugi/azide MCR as a tool to rapidly broaden substrate scope. Title compounds were screened against a cancer cell panel, and I (R¹ = H; R² = 1-phenylethyl) exhibited selective, antiproliferative activity against the MCF-7 (breast cancer) cell line. This C-H activation methodol. can be utilized to rapidly reach new chem.-space for drug discovery.

Organic Chemistry Frontiers published new progress about 1174626-28-8. 1174626-28-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine,Benzene,Ether, name is 2-Amino-6-benzyloxypyridine, and the molecular formula is C12H12N2O, HPLC of Formula: 1174626-28-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem