Category: pyridine-derivatives

Schneider, D. published the artcileInfluence of 3 antivertiginous medications on the vigilance of healthy volunteers, Product Details of C10H20N2O6S2, the publication is International Journal of Clinical Pharmacology and Therapeutics (2003), 41(4), 171-181, database is CAplus and MEDLINE.

In the present randomized, comparative, double-blind, 3-way crossover study, possible effects of 3 antivertiginous medications on vigilance were investigated. Thirty healthy volunteers received single doses of a fixed combination of cinnarizine 20 mg and dimenhydrinate 40 mg (Arlevert, ARL), dimenhydrinate 50 mg, or betahistine dimesylate 12 mg, in randomized order at 1-wk intervals. Spontaneous brain elec. activity (EEG), acoustic late evoked potentials (ALEP) with P300, and reaction time were measured before and 90 (t₉₀) and 180 min (t₁₈₀) after drug intake. All 3 medications led to a delay of P300 (primary criterion) and a decrease of its amplitude. The maximum delay at t₁₈₀ was found for dimenhydrinate (16.42 ms) and the lowest for betahistine (6.33 ms). The differences in ARL vs. dimenhydrinate and ARL vs. betahistine were not statistically significant (p > 0.05). Spectral anal. of spontaneous EEG showed slight and similar decreases in the power in the α-band under dimenhydrinate and ARL (p = 0.07 and p = 0.03 with respect to baseline, resp.), but basically no change under betahistine. There was no effect on reaction time by either medication. None of the subjects reported drowsiness or any other adverse event. The findings confirm the reported suitability of P300 latency for measurement of drug effects on brain activity, but provide no indication of concomitant impairment of performance capacity by the tested drugs. Global assessment of the results suggests that the fixed combination cinnarizine 20 mg/dimenhydrinate 40 mg exerts only a minor effect on vigilance, not significantly different from betahistine, which is commonly regarded as a non-sedating antivertiginous drug.

International Journal of Clinical Pharmacology and Therapeutics published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, Product Details of C10H20N2O6S2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Oh, In-Chan published the artcileCharacterization of palladium electrodeposition in ammonia-free electrolyte with additives, Product Details of C5H5NO3S, the publication is Surface and Interface Analysis (2021), 53(12), 1035-1042, database is CAplus.

Electrodeposition of Pd provides excellent chem. and low-contact resistance with good elec. properties, such as different types of elec. contacts in the electronics industry. The conventional Pd plating process utilizes ammonia-based electrolytes. Ammonia was added continuously to maintain the optimum pH range in Pd electrolyte. In addition, the harmful and strong odor of the evaporating ammonia necessitates the use of a ventilator. A further disadvantage is that the brass substrate is corroded by ammonia vapor, and the corrosion products can contaminate the electrolytes, thereby changing the technol. properties of the deposited plating for the worse. Ethylenediamine has been proposed as an alternative to ammonia; however, Pd electrodeposition occurs as microcracks via hydrogen evolution. In this study, the effects of Pd electrolyte on ethylenediamine as a complexing agent and the properties of various additives are investigated to improve c.d. and internal stress in Pd electrodeposition that occurs on a brass substrate. Therefore, complexing agents such as 3-pyridine sulfonic acid, sodium nicotinate, butyne 1-4 diol, and sodium allylsulfonate are selected as additives, to serve as an alternative to ammonia in Pd electrolyte. In this study, the properties of electrodeposited Pd with various additives were examined The effect of additives on Pd electrolytes can be classified as dense surfaces without defects such as microcracks and pinholes, which improved surface roughness and corrosion resistance. Particularly, Pd electrolyte using sodium nicotinate has relatively improved surface roughness and properties. Pd electrolyte was optimized under ammonia-free conditions by the addition of sodium nicotinate.

Surface and Interface Analysis published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Product Details of C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hong, Seunghee published the artcileDiscovery of New Benzothiazole-Based Inhibitors of Breakpoint Cluster Region-Abelson Kinase Including the T315I Mutant, COA of Formula: C6H8BNO3, the publication is Journal of Medicinal Chemistry (2013), 56(9), 3531-3545, database is CAplus and MEDLINE.

The existence of drug resistance caused by mutations in the break-point cluster region-Abelson tyrosine kinase (Bcr-Abl) kinase domain remains a clin. challenge due to limited effective treatment options for chronic myeloid leukemia. Herein the authors report a novel series of benzothiazole-based inhibitors that are effective against wild-type and T315I mutant Bcr-Abl kinases. The original hit compound, nocodazole, was extensively modified through a structure-based drug design strategy, especially by varying the groups at the C2 and C6 positions of the scaffold. In addition, the introduction of water-solubilizing groups at the terminal Et group resulted in enhanced physicochem. properties and potency in cellular inhibition. Several compounds inhibited the kinase activity of both wild-type Bcr-Abl and the T315I mutant with IC₅₀ values in the picomolar range and exhibited good antiproliferative effects on Ba/F3 cell lines transformed with either wild-type or T315I mutant Bcr-Abl.

Journal of Medicinal Chemistry published new progress about 1008506-24-8. 1008506-24-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Pyridine,Boronic Acids,Boronic acid and ester, name is 3-Methoxypyridine-4-boronic acid, and the molecular formula is C6H8BNO3, COA of Formula: C6H8BNO3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Dau, Phuong V. published the artcileSingle-Atom Ligand Changes Affect Breathing in an Extended Metal-Organic Framework, Product Details of C13H13N, the publication is Inorganic Chemistry (2012), 51(10), 5671-5676, database is CAplus and MEDLINE.

2-Phenylpyridine-5,4′-dicarboxylic acid (1, dcppy), a derivative of 4,4′-biphenyldicarboxylic (2, bpdc) was used as the organic linking component for several metal-organic frameworks (MOFs). The pyridine component of 1 does not interfere with the solvothermal synthetic procedure, and hence both 1 and 2 form similar isoreticular MOFs. Zr⁴⁺-based UiO-67-dcppy, Al³⁺-based DUT-5-dcppy, Zn²⁺-based DMOF-1-dcppy, and interpenetrated Zn²⁺-based BMOF-1-dcppy were readily synthesized from 1. Similarly, isostructural frameworks from 2 were prepared (UiO-67, DUT-5, DMOF-1-bpdc, and interpenetrated BMOF-1-bpdc). The structures and phys. properties of these frameworks were characterized by powder x-ray diffraction (PXRD), single XRD, TGA, and gas sorption anal. Generally, frameworks prepared from 1 or 2 displayed similar properties; however, gas sorption data showed that BMOF-1-dcppy displayed a very large hysteresis with N₂ and CO₂ suggestive of possible framework flexibility. In contrast, the analogous framework prepared from 2 (BMOF-1-bpdc) showed low uptake of N₂ and CO₂. The substantial difference in the gas sorption behavior of these MOFs is attributed to the pyridine nature of 1 that results in weakened π-π interactions between the interpenetrated nets.

Inorganic Chemistry published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C13H13N, Product Details of C13H13N.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lu, Xiao published the artcileAcid-Promoted Cascade Reaction of N-(4-Chloroquinolin-3-yl)carbamates with Amines: One-Pot Assembly of Imidazo[4,5-c]quinolin-2-ones, Recommanded Product: (6-Hydroxypyridin-3-yl)boronic acid, the publication is European Journal of Organic Chemistry (2018), 2018(13), 1572-1580, database is CAplus and MEDLINE.

An acid-promoted cascade reaction of N-(4-chloroquinolin-3-yl)carbamates with amines is described. This method achieves the formation of two new C-N bonds through an intermol. amination/intramol. cyclization reaction sequence. In combination with a subsequent Suzuki coupling reaction, this three-component telescopic procedure provides rapid access to various bioactive imidazo[4,5-c]quinolin-2-one derivatives

European Journal of Organic Chemistry published new progress about 903899-13-8. 903899-13-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Alcohol,Boronic Acids,Boronic acid and ester, name is (6-Hydroxypyridin-3-yl)boronic acid, and the molecular formula is C5H6BNO3, Recommanded Product: (6-Hydroxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Imai, Yoshitane published the artcileCharge-transfer host system composed of 9,10-bis(3,5-dihydroxyphenyl)anthracene and methylviologen, Product Details of C22H18Cl2N2, the publication is Tetrahedron (2009), 65(18), 3740-3744, database is CAplus.

By using 9,10-bis(3,5-dihydroxyphenyl)anthracene as an electron donor and 1,1′-dimethyl-4,4′-bipyridinium dichloride as an electron acceptor, a spontaneously resolved charge-transfer (CT) complex is formed. This CT complex can include n-alkyl alc. mols. as guests, and the DRS of this CT complex change with the type of component guest mols.

Tetrahedron published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Product Details of C22H18Cl2N2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Imai, Yoshitane published the artcileFormation of chiral charge-transfer complex with axially chiral 1,1′-bi-2-naphthol and viologen derivatives, Computed Properties of 47369-00-6, the publication is Tetrahedron Letters (2006), 47(21), 3603-3606, database is CAplus.

By using three types of viologen derivatives, we synthesized chiral charge-transfer (CT) complexes with an axially chiral 1,1′-bi-2-naphthol mol. and successfully controlled the crystal structure and inclusion ability of the third component by changing the viologens.

Tetrahedron Letters published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Computed Properties of 47369-00-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Okamura, H. published the artcileEcotoxicity of the degradation products of triphenylborane pyridine (TPBP) antifouling agent, Category: pyridine-derivatives, the publication is Chemosphere (2009), 74(9), 1275-1278, database is CAplus and MEDLINE.

Triphenylborane pyridine (TPBP) is an alternative to organotin antifouling compounds This work aimed to identify the unknown Peak #1, and to evaluate the ecotoxicity of TPBP and its degradation products. Peak #1 was produced from TPBP dissolved in acetonitrile under UV-A photolysis using a high-pressure Hg lamp. The Peak #1 fraction was purified using 2-step column chromatog. from a TPBP-acetonitrile solution The major compound of the fraction was identified as being biphenyl from the ¹H NMR and ¹³C NMR spectra. The ecotoxicity of 4 degradation products (diphenylborane hydroxide, phenylborane dihydroxide, phenol, and biphenyl) and TPBP towards 2 marine planktons were assessed. The 48 h LC₅₀ values of the crustacean, Artemia salina, were 0.13 mg L^-1 for TPBP, 14 mg L^-1 for biphenyl, 17 mg L^-1 for phenol, and >50 mg L^-1 for the other degradation products. The 72 h EC₅₀ values of the diatom, Skeletonema costatum, were 0.0022 mg L^-1 for TPBP, 1.2 mg L^-1 for biphenyl, and >2 mg L^-1 for the other degradation products. Thus, the ecotoxicity of biphenyl and the other degradation products were not high compared to the parent compound, TPBP.

Chemosphere published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lee, Dong-Hwan published the artcileHighly active and recyclable silica gel-supported palladium catalyst for mild cross-coupling reactions of unactivated heteroaryl chlorides, Recommanded Product: 2-Pyridinylboronic acid, the publication is Green Chemistry (2010), 12(11), 2024-2029, database is CAplus.

Silica gel-supported β-ketoiminatophosphane-Pd complex (Pd@O₂) was shown to be a highly active and long-lived catalyst for aqueous Suzuki, Stille and Sonogashira coupling reactions of heteroaryl chlorides. A wide range of heteroaryl chlorides could be efficiently coupled with different nucleophilic partners in the presence of only 0.5 mol% catalyst and under mild conditions. This is one of the most powerful heterogeneous catalysts for the couplings of diverse heteroaryl chlorides. Furthermore, the catalyst could be reused with almost consistent activity.

Green Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Recommanded Product: 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Krah, Sabrina published the artcileElectron-Rich Silicon Containing Phosphinanes for Rapid Pd-Catalyzed C-X Coupling Reactions, Formula: C5H6BNO2, the publication is ChemCatChem (2022), 14(16), e202200734, database is CAplus.

Novel silicon-containing phosphine, 4,1-phosphasilinane 2-TripC₆H₄P(CH₂CH₂)₂SiMe₂ (SabPhos, Trip = 2,4,6-ⁱPr₃C₆H₂) was prepared as a ligand for palladium-catalyzed coupling reactions. Palladium-catalyzed cross-coupling reactions are among the most useful and efficient methods for direct access to complex structures in organic synthesis. However, heteroatom-containing compounds can complicate such coupling reactions due to their competitive coordination with the palladium catalyst and electronic effects. As a result, good yields are often only obtained under harsher reaction conditions, such as high temperatures and long reaction times. Here the design of a highly active phosphine ligand is reported that provides excellent yields for C-N coupling reactions at ambient temperature Incorporation of the phosphorus atom into a cyclohexane ring maintains the pyramidal structure of the phosphorus while reducing steric hindrance. This, and a silicon atom in the cyclohexane moiety, results in an electron-rich phosphinane ligand. This novel silicon containing SabPhos ligand can be obtained in excellent yields in a straightforward synthesis. In palladium catalyzed reactions, this ligand facilitates the coupling of a broad range of heteroaryl chlorides via C-C bonds with boronic acids and C-N bonds with secondary amines in excellent yields under mild conditions.

ChemCatChem published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem